Chlorhexidine gluconate
Avagard, Bioscrub, Chg, Chloraprep, Chloraprep One-step, Chloraprep Swabstick, Chlorhexidine, Cida-stat, Exidine, Hibiclens, Hibistat, Peridex, Periogard, Prevantics, Prevantics Swabstick, Soluprep (chlorhexidine gluconate) is a small molecule pharmaceutical. Chlorhexidine gluconate was first approved as Hibiclens on 1982-01-01. It is used to treat gram-negative bacterial infections, gram-positive bacterial infections, infectious skin diseases, oral candidiasis, and periodontal diseases in the USA.
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| (qiqing) chlorhexidine gluconate alcohol disinfectant | OTC monograph not final | 2020-05-15 |
| 3m avagard | New Drug Application | 2024-08-01 |
| 3m soluprep s | New Drug Application | 2024-08-01 |
| acclean chlorhexidine gluconate 0.12% oral rinse | ANDA | 2025-05-28 |
| antibacterial protective hand | unapproved drug other | 2013-02-01 |
| antimicrobial foam handwash | New Drug Application | 2018-08-24 |
| antimicrobial skin cleanser | New Drug Application | 2019-06-18 |
| antiseptic cleansing wipes | unapproved drug other | 2018-10-08 |
| antiseptic foam handwash | New Drug Application | 2018-08-24 |
| antiseptic skin cleanser | New Drug Application | 2025-04-30 |
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Agency Specific
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EMA
Expiration | Code | ||
|---|---|---|---|
CHLORHEXIDINE GLUCONATE / ISOPROPYL ALCOHOL, SOLUPREP S, 3M HEALTH CARE | |||
| 2026-01-20 | M-292 | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Chlorhexidine Gluconate, Chlorhexidine Gluconate, Sage Prods | |||
| 7935093 | 2027-10-02 | DP | U-1022 |
| 7427574 | 2026-04-25 | DP | |
| 7717889 | 2025-02-27 | DP | U-1022 |
| 7066916 | 2024-02-17 | U-737 | |
| Chlorhexidine Gluconate / Isopropyl Alcohol, Chloraprep One-Step, Becton Dickinson Co | |||
| 7422388 | 2027-04-25 | DP | U-1397 |
| 6991394 | 2024-01-31 | DP | |
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB03: Chlorhexidine
B: Blood and blood forming organ drugs
— B05: Blood substitutes and perfusion solutions
— B05C: Irrigating solutions, blood substitutes and perfusion
— B05CA: Antiinfective irrigating solutions
— B05CA02: Chlorhexidine
D: Dermatologicals
— D08: Antiseptics and disinfectants
— D08A: Antiseptics and disinfectants
— D08AC: Biguanides and amidines as antiseptics and disinfectants
— D08AC02: Chlorhexidine
— D08AC52: Chlorhexidine, combinations
— D09: Medicated dressings
— D09A: Medicated dressings
— D09AA: Medicated dressings with antiinfectives
— D09AA12: Chlorhexidine
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AA: Antiseptic throat preparations
— R02AA05: Chlorhexidine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AX: Other antiinfectives in atc
— S01AX09: Chlorhexidine
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA09: Chlorhexidine
— S03: Ophthalmological and otological preparations
— S03A: Antiinfectives, ophthalmologic and otologic
— S03AA: Antiinfectives
— S03AA04: Chlorhexidine
HCPCS
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Clinical
Clinical Trials
70 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Surgical wound infection | D013530 | — | — | 2 | 3 | 5 | 5 | 3 | 18 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | 1 | 5 | 4 | 11 |
| Communicable diseases | D003141 | — | — | — | 1 | 3 | 3 | 1 | 8 |
| Wound infection | D014946 | — | — | — | — | 1 | 2 | 1 | 4 |
| Healthy volunteers/patients | — | — | — | — | — | 1 | 2 | — | 3 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | — | — | 2 | 1 | 3 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | — | — | 1 | 1 | 2 |
| Propionibacterium acnes | D011425 | NCBITaxon_1747 | — | — | — | — | 1 | 1 | 2 |
| Replacement arthroplasty hip | D019644 | — | — | — | — | — | 1 | 1 | 2 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | 1 | — | 1 |
Show 14 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain management | D059408 | — | — | — | — | 1 | — | — | 1 |
| Postoperative complications | D011183 | — | — | — | — | 1 | — | — | 1 |
| Surgical wound | D000072836 | — | — | — | — | 1 | — | — | 1 |
| Headache | D006261 | — | R51 | — | — | 1 | — | — | 1 |
| Post-dural puncture headache | D051299 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cesarean section | D002585 | — | — | — | 1 | — | — | 1 | 2 |
| Cross infection | D003428 | — | — | — | 1 | — | — | — | 1 |
| Preoperative care | D011300 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | — | — | — | 1 | 1 |
| Contraception | D003267 | — | — | — | — | — | — | 1 | 1 |
| Conization | D019092 | — | — | — | — | — | — | 1 | 1 |
| Personal satisfaction | D010549 | — | — | — | — | — | — | 1 | 1 |
| Endometritis | D004716 | EFO_1001312 | — | — | — | — | — | 1 | 1 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Replacement arthroplasty | D019643 | — | — | — | — | — | — | 1 | 1 |
| Obstetric labor complications | D007744 | — | — | — | — | — | — | 1 | 1 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 1 | 1 |
| Blood culture | D000071997 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Chlorhexidine gluconate |
| INN | chlorhexidine |
| Description | Chlorhexidine is a bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge. It has a role as an antiinfective agent and an antibacterial agent. It is a member of biguanides and a member of monochlorobenzenes. It is functionally related to a biguanide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1.O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO |
Identifiers
| PDB | — |
| CAS-ID | 18472-51-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297088 |
| ChEBI ID | — |
| PubChem CID | 9552079 |
| DrugBank | DB00878 |
| UNII ID | R4KO0DY52L (ChemIDplus, GSRS) |
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5,798 adverse events reported
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