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Drug ReportsChloraprep
Chlorhexidine gluconate
Avagard, Bioscrub, Chg, Chloraprep, Chloraprep One-step, Chloraprep Swabstick, Chlorhexidine, Cida-stat, Exidine, Hibiclens, Hibistat, Peridex, Periogard, Prevantics, Prevantics Swabstick, Soluprep (chlorhexidine gluconate) is a small molecule pharmaceutical. Chlorhexidine gluconate was first approved as Hibiclens on 1982-01-01. It is used to treat gram-negative bacterial infections, gram-positive bacterial infections, infectious skin diseases, oral candidiasis, and periodontal diseases in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
stomatognathic diseasesD009057
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name
Status
Last Update
(qiqing) chlorhexidine gluconate alcohol disinfectantOTC monograph not final2020-05-15
3m avagardNew Drug Application2024-08-01
3m avagard dC2002632024-08-01
3m avagard foaming instant hand antisepticC2002632024-08-01
3m avagard foaming instant hand antisepticOTC monograph not final2011-05-19
3m soluprep sNew Drug Application2024-08-01
acclean chlorhexidine gluconate 0.12% oral rinseANDA2023-02-28
alcohol disinfectant wipesOTC monograph not final2020-06-24
anti mucedine feminine washunapproved drug other2021-04-20
anti-bacterial gelC2002632024-05-16
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration
Code
CHLORHEXIDINE GLUCONATE / ISOPROPYL ALCOHOL, SOLUPREP S, 3M HEALTH CARE
2026-01-20M-292
Patent Expiration
Patent
Expires
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FDA Information
Chlorhexidine Gluconate, Chlorhexidine Gluconate, Sage Prods
79350932027-10-02DPU-1022
74275742026-04-25DP
77178892025-02-27DPU-1022
70669162024-02-17U-737
Chlorhexidine Gluconate / Isopropyl Alcohol, Chloraprep One-Step, Becton Dickinson Co
74223882027-04-25DPU-1397
69913942024-01-31DP
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB03: Chlorhexidine
B: Blood and blood forming organ drugs
— B05: Blood substitutes and perfusion solutions
— B05C: Irrigating solutions, blood substitutes and perfusion
— B05CA: Antiinfective irrigating solutions
— B05CA02: Chlorhexidine
D: Dermatologicals
— D08: Antiseptics and disinfectants
— D08A: Antiseptics and disinfectants
— D08AC: Biguanides and amidines as antiseptics and disinfectants
— D08AC02: Chlorhexidine
— D08AC52: Chlorhexidine, combinations
— D09: Medicated dressings
— D09A: Medicated dressings
— D09AA: Medicated dressings with antiinfectives
— D09AA12: Chlorhexidine
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AA: Antiseptic throat preparations
— R02AA05: Chlorhexidine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AX: Other antiinfectives in atc
— S01AX09: Chlorhexidine
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA09: Chlorhexidine
— S03: Ophthalmological and otological preparations
— S03A: Antiinfectives, ophthalmologic and otologic
— S03AA: Antiinfectives
— S03AA04: Chlorhexidine
HCPCS
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Clinical
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1105 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
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Total
PeriodontitisD010518EFO_0000649K05.3———1—1
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
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Total
Breast neoplasmsD001943EFO_0003869C50—1———1
Non-small-cell lung carcinomaD002289———1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfectionsD007239EFO_0000544—————11
Communicable diseasesD003141——————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameChlorhexidine gluconate
INNchlorhexidine
Description
Chlorhexidine is a bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge. It has a role as an antiinfective agent and an antibacterial agent. It is a member of biguanides and a member of monochlorobenzenes. It is functionally related to a biguanide.
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1.O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
Identifiers
PDB—
CAS-ID18472-51-0
RxCUI—
ChEMBL IDCHEMBL4297088
ChEBI ID—
PubChem CID9552079
DrugBankDB00878
UNII IDR4KO0DY52L (ChemIDplus, GSRS)
Target
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Trends
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Safety
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11,234 adverse events reported
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