Cetrotide(cetrorelix)
Cetrorelix, Cetrotide (cetrorelix) is a protein pharmaceutical. Cetrorelix was first approved as Cetrotide on 1999-04-12. It is used to treat ovarian hyperstimulation syndrome in the USA. It has been approved in Europe to treat ovulation and ovulation induction. The pharmaceutical is active against gonadotropin-releasing hormone receptor.
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Commercial
Trade Name
FDA
EMA
Cetrotide (generic drugs available since 2022-08-12)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cetrorelix acetate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CETROTIDE | EMD Serono | N-021197 RX | 2000-08-11 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cetrorelix | ANDA | 2023-07-31 |
| cetrotide | New Drug Application | 2023-12-22 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| ovarian hyperstimulation syndrome | — | D016471 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
126 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infertility | D007246 | HP_0000789 | — | 2 | 10 | 6 | 19 | 17 | 50 |
| Female infertility | D007247 | EFO_0008560 | N97 | 1 | 3 | 5 | 1 | 3 | 11 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 1 | 1 | 2 | 3 | 4 | 10 |
| Fertilization in vitro | D005307 | — | — | — | — | — | 7 | 3 | 10 |
| Ovarian hyperstimulation syndrome | D016471 | — | — | 1 | 1 | 1 | 1 | 3 | 6 |
| Intracytoplasmic sperm injections | D020554 | — | — | — | — | — | 5 | — | 5 |
| Fertility | D005298 | — | — | — | — | — | 1 | 2 | 3 |
| Leiomyoma | D007889 | HP_0000131 | D25 | 1 | 1 | — | 1 | — | 2 |
| Left ventricular dysfunction | D018487 | — | — | — | — | — | 1 | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | — | — | 3 | — | — | 3 |
| Assisted reproductive techniques | D027724 | — | — | — | — | 1 | — | 1 | 2 |
| Parents | D010290 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ectopic pregnancy | D011271 | — | O00 | 1 | 1 | — | — | 1 | 2 |
| Endometriosis | D004715 | EFO_0001065 | N80 | 1 | 2 | — | — | — | 2 |
| Ovulation induction | D010062 | — | — | — | 2 | — | — | — | 2 |
| Male breast neoplasms | D018567 | — | — | 1 | 1 | — | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | 1 | 1 | — | — | — | 1 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | 1 | 1 | — | — | — | 1 |
| Salpingitis | D012488 | — | N70.91 | 1 | 1 | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | — | 1 |
| Menopause | D008593 | EFO_0003922 | N95 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 2 | 2 |
| Healthy volunteers/patients | — | — | — | — | — | — | — | 1 | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | — | — | 1 | 1 |
| Preimplantation diagnosis | D019836 | — | — | — | — | — | — | 1 | 1 |
| Ovarian pregnancy | D065172 | — | O00.2 | — | — | — | — | 1 | 1 |
| Premenopause | D017697 | — | — | — | — | — | — | 1 | 1 |
| Female genital diseases | D005831 | EFO_0009549 | N85 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cetrorelix |
| INN | cetrorelix |
| Description | CETRORELIX |
| Classification | Protein |
| Drug class | hormone-release inhibiting peptides |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](Cc1cccnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 120287-85-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200490 |
| ChEBI ID | 59224 |
| PubChem CID | 16130924 |
| DrugBank | DB00050 |
| UNII ID | OON1HFZ4BA (ChemIDplus, GSRS) |
Target
Agency Approved
GNRHR
GNRHR
Organism
Homo sapiens
Gene name
GNRHR
Gene synonyms
GRHR
NCBI Gene ID
Protein name
gonadotropin-releasing hormone receptor
Protein synonyms
gnRH receptor, gnRH-R, gonadotropin-releasing hormone (type 1) receptor 1, leutinizing hormone releasing horomone receptor, leutinizing-releasing hormone receptor, luliberin receptor, type I GnRH receptor
Uniprot ID
Mouse ortholog
Gnrhr (14715)
gonadotropin-releasing hormone receptor (Q61611)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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482 adverse events reported
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