Cerdulatinib
Cerdulatinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target tyrosine-protein kinase JAK1, NUAK family SNF1-like kinase 1, non-receptor tyrosine-protein kinase TYK2, tyrosine-protein kinase SYK, mitogen-activated protein kinase kinase kinase 9, macrophage colony-stimulating factor 1 receptor, tyrosine-protein kinase JAK2, tyrosine-protein kinase JAK3, and serine/threonine-protein kinase 4.
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Clinical Trials
4 clinical trials
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 1 | — | — | 1 | 2 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | 1 | — | — | 1 | 2 |
| Leukemia | D007938 | — | C95 | 1 | 1 | — | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | 1 | 1 | — | — | — | 1 |
| T-cell lymphoma | D016399 | — | — | 1 | 1 | — | — | — | 1 |
| Hodgkin disease | D006689 | — | C81 | 1 | 1 | — | — | — | 1 |
| Follicular lymphoma | D008224 | — | C82 | 1 | 1 | — | — | — | 1 |
| B-cell lymphoma | D016393 | — | — | 1 | 1 | — | — | — | 1 |
| Lymphoid leukemia | D007945 | — | C91 | 1 | 1 | — | — | — | 1 |
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Epidemiology
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Drug
General
| Drug common name | Cerdulatinib |
| INN | cerdulatinib |
| Description | Cerdulatinib is a small molecule SYK/JAK kinase inhibitor in development for treatment of hematological malignancies. It has lowest nM IC50 values against TYK2, JAK1, JAK2, JAK3, FMS, and SYK.
|
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 1198300-79-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4116008 |
| ChEBI ID | — |
| PubChem CID | 44595079 |
| DrugBank | — |
| UNII ID | D1LXQ45S1O (ChemIDplus, GSRS) |
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