Cephalothin
Keflin, Seffin (cephalothin) is a small molecule pharmaceutical. Cephalothin was first approved as Keflin on 1982-01-01. It is used to treat bacterial skin diseases, escherichia coli infections, klebsiella infections, proteus infections, and respiratory tract infections amongst others in the USA. It is known to target organic anion transporter 3 and solute carrier family 22 member 11.
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HCPCS
Code | Description |
|---|---|
| J1890 | Injection, cephalothin sodium, up to 1 gram |
Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cystitis | D003556 | EFO_1000025 | N30 | — | — | — | 1 | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 1 | 1 |
| Femoral neck fractures | D005265 | EFO_1001792 | S72.00 | — | — | — | — | 1 | 1 |
| Ventral hernia | D006555 | EFO_1001866 | K43 | — | — | — | — | 1 | 1 |
| Hernia | D006547 | HP_0100790 | K40-K46 | — | — | — | — | 1 | 1 |
| Incisional hernia | D000069290 | HP_0004872 | K43.2 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cephalothin |
| INN | cefalotin |
| Description | Cefalotin is a semisynthetic, first-generation cephalosporin antibiotic with acetoxymethyl and (2-thienylacetyl)nitrilo moieties at positions 3 and 7, respectively, of the core structure. Administered parenterally during surgery and to treat a wide spectrum of blood infections. It has a role as an antimicrobial agent and an antibacterial drug. It is a semisynthetic derivative, a beta-lactam antibiotic allergen, a cephalosporin, a carboxylic acid, a member of thiophenes and an azabicycloalkene. It is a conjugate acid of a cefalotin(1-). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)Cc3cccs3)[C@H]2SC1 |
Identifiers
| PDB | — |
| CAS-ID | 153-61-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL617 |
| ChEBI ID | 124991 |
| PubChem CID | 6024 |
| DrugBank | DB00456 |
| UNII ID | R72LW146E6 (ChemIDplus, GSRS) |
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Safety
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79 adverse events reported
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