Cenerimod
Cenerimod is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against sphingosine 1-phosphate receptor 1.
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Commercial
No data
Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | 1 | 2 | 4 | — | — | 6 |
| Connective tissue diseases | D003240 | EFO_1001986 | M35 | — | 1 | 3 | — | — | 4 |
| Immune system diseases | D007154 | — | D89.9 | — | — | 3 | — | — | 3 |
| Autoimmune diseases | D001327 | EFO_0000540 | M30-M36 | — | — | 3 | — | — | 3 |
| Skin and connective tissue diseases | D017437 | — | — | — | — | 1 | — | — | 1 |
| Lupus nephritis | D008181 | EFO_0005761 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 7 | — | — | — | — | 7 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cenerimod |
| INN | cenerimod |
| Description | Cenerimod is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against sphingosine 1-phosphate receptor 1. |
| Classification | Small molecule |
| Drug class | immunomodulators |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCc1cc(-c2noc(-c3cc(OC)nc(C4CCCC4)c3)n2)cc(C)c1OC[C@@H](O)CO |
Identifiers
| PDB | — |
| CAS-ID | 1262414-04-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297505 |
| ChEBI ID | — |
| PubChem CID | 49871973 |
| DrugBank | DB12705 |
| UNII ID | Y333RS1786 (ChemIDplus, GSRS) |
Target
Agency Approved
S1PR1
S1PR1
Organism
Homo sapiens
Gene name
S1PR1
Gene synonyms
CHEDG1, EDG1
NCBI Gene ID
Protein name
sphingosine 1-phosphate receptor 1
Protein synonyms
CD363, Endothelial differentiation G-protein coupled receptor 1, endothelial differentiation, sphingolipid G-protein-coupled receptor, 1, S1P receptor Edg-1, Sphingosine 1-phosphate receptor Edg-1, sphingosine 1-phosphate receptor EDG1
Uniprot ID
Mouse ortholog
S1pr1 (13609)
sphingosine 1-phosphate receptor 1 (Q9R235)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 107 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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