Ceftriaxone
Ceftriaxone, Rocephin (ceftriaxone) is a small molecule pharmaceutical. Ceftriaxone was first approved as Rocephin on 1984-12-21. It is used to treat acinetobacter infections, bacterial infections, bacterial meningitis, bacterial pneumonia, and bacterial skin diseases amongst others in the USA.
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Ceftriaxone (discontinued: Ceftriaxone, Rocephin)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ceftriaxone sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CEFTRIAXONE AND DEXTROSE IN DUPLEX CONTAINER | B. Braun Medical | N-050796 RX | 2005-04-20 | 2 products, RLD, RS |
Show 2 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ceftriaxone | ANDA | 2026-09-30 |
| ceftriaxone and dextrose | New Drug Application | 2022-01-13 |
| ceftriaxone ceftriaxone | ANDA | 2019-08-14 |
| ceftriaxone sodium | ANDA | 2026-07-23 |
| easy-ceft | ANDA | 2021-01-07 |
Indications
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Agency Specific
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| J0696 | Injection, ceftriaxone sodium, per 250 mg |
Clinical
Clinical Trials
277 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 4 | 10 | 15 | 15 | 9 | 52 |
| Pneumonia | D011014 | EFO_0003106 | J18 | 1 | 9 | 22 | 11 | 9 | 47 |
| Communicable diseases | D003141 | — | — | 3 | 4 | 12 | 8 | 6 | 33 |
| Gonorrhea | D006069 | DOID_7551 | A54 | 2 | 3 | 8 | 3 | 3 | 19 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | 1 | 8 | 5 | 6 | 19 |
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | 6 | 12 | 1 | — | 16 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | 1 | 2 | 5 | 3 | 3 | 13 |
| Appendicitis | D001064 | EFO_0007149 | K37 | 1 | 2 | — | 4 | 5 | 12 |
| Community-acquired pneumonia | D000098968 | — | — | — | — | 4 | 3 | 1 | 8 |
| Intraabdominal infections | D059413 | — | — | — | — | 5 | 3 | — | 8 |
Show 69 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | 2 | 4 | 3 | — | 1 | 9 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 2 | 3 | — | 3 | 6 |
| Bacterial infections | D001424 | — | A49 | — | — | 1 | — | 5 | 6 |
| Healthy volunteers/patients | — | — | — | 4 | 3 | 1 | — | — | 5 |
| Post-lyme disease syndrome | D000077342 | — | — | 2 | 1 | 2 | — | — | 4 |
| Microbial drug resistance | D004352 | — | — | — | — | 1 | — | 2 | 3 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | 1 | 3 | — | — | 3 |
| Antibiotic prophylaxis | D019072 | — | — | — | 1 | 1 | — | 1 | 3 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | — | 1 | 2 | — | — | 2 |
| Community-acquired infections | D017714 | — | — | — | 1 | 2 | — | — | 2 |
Show 27 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chlamydia infections | D002690 | EFO_0007205 | A74.9 | — | 1 | — | — | 2 | 3 |
| Coinfection | D060085 | — | — | — | 1 | — | — | 2 | 3 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 1 | — | — | 1 | 2 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 1 | — | — | 1 | 2 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | 1 | — | — | — | 1 |
| Inflammatory bowel diseases | D015212 | EFO_0003767 | — | — | 1 | — | — | — | 1 |
| Colitis | D003092 | EFO_0003872 | K52.9 | — | 1 | — | — | — | 1 |
| Ulcer | D014456 | MPATH_579 | — | — | 1 | — | — | — | 1 |
| Subacute bacterial endocarditis | D004698 | EFO_1001193 | — | — | 1 | — | — | — | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | — | — | — | 1 |
Show 24 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | 1 | — | — | — | 1 | 2 |
| Acute disease | D000208 | — | — | 1 | — | — | — | 1 | 2 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | 1 | 2 |
| Male genital diseases | D005832 | EFO_0009555 | N50.9 | 1 | — | — | — | — | 1 |
| Male urogenital diseases | D052801 | — | — | 1 | — | — | — | — | 1 |
| Prostatic diseases | D011469 | — | N42.9 | 1 | — | — | — | — | 1 |
| Hyperplasia | D006965 | EFO_0000536 | — | 1 | — | — | — | — | 1 |
| Urogenital diseases | D000091642 | — | — | 1 | — | — | — | — | 1 |
| Genital diseases | D000091662 | — | — | 1 | — | — | — | — | 1 |
| Colonic neoplasms | D003110 | — | C18 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Jaundice | D007565 | — | R17 | — | — | — | — | 2 | 2 |
| Benign migratory glossitis | D005929 | EFO_0007283 | K14.1 | — | — | — | — | 2 | 2 |
| Erythema chronicum migrans | D015787 | — | A26.0 | — | — | — | — | 2 | 2 |
| Erythema | D004890 | — | L53.9 | — | — | — | — | 2 | 2 |
| Mastitis | D008413 | EFO_1001034 | N61 | — | — | — | — | 2 | 2 |
| Renal insufficiency | D051437 | — | N19 | — | — | — | — | 2 | 2 |
| Pharmacokinetics | D010599 | — | — | — | — | — | — | 2 | 2 |
| Ultrasonography | D014463 | — | — | — | — | — | — | 1 | 1 |
| Lower urinary tract symptoms | D059411 | EFO_0008008 | — | — | — | — | — | 1 | 1 |
| Clostridium botulinum type a | D047013 | — | — | — | — | — | — | 1 | 1 |
Show 59 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ceftriaxone |
| INN | ceftriaxone |
| Description | Ceftriaxone is a third-generation cephalosporin compound having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups. It has a role as an antibacterial drug, an EC 3.5.2.6 (beta-lactamase) inhibitor and a drug allergen. It is a cephalosporin, a member of 1,2,4-triazines, a member of 1,3-thiazoles and an oxime O-ether. It is a conjugate acid of a ceftriaxone(1-). |
| Classification | Small molecule |
| Drug class | cephalosporins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(O)nn3C)CS[C@H]12)c1csc(N)n1 |
Identifiers
| PDB | — |
| CAS-ID | 73384-59-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL161 |
| ChEBI ID | 29007 |
| PubChem CID | 5479530 |
| DrugBank | DB01212 |
| UNII ID | 75J73V1629 (ChemIDplus, GSRS) |
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Rocephin – Roche
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Ceftriaxone
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26,291 adverse events reported
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