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Drug ReportsCeftobiprole
Ceftobiprole
Zevtera (ceftobiprole) is a small molecule pharmaceutical. Ceftobiprole was first approved as Zevtera on 2024-04-03. It is used to treat bacteremia, methicillin-resistant staphylococcus aureus, and pneumonia in the USA.
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zevteraNew Drug Application2025-03-21
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ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01D: Other beta-lactam antibacterials in atc
— J01DI: Other cephalosporins and penems in atc
— J01DI01: Ceftobiprole medocaril
HCPCS
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Clinical
Clinical Trials
28 clinical trials
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Indications Phases 4
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Ontology
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Renal insufficiencyD051437—N19————11
Liver failureD017093—K72.9————11
Hepatic insufficiencyD048550——————11
Immunosuppression therapyD007165——————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCeftobiprole
INNceftobiprole
Description
Ceftobiprole (Zevtera/Mabelio) is a fifth-generation cephalosporin for the treatment of hospital-acquired pneumonia (excluding ventilator-associated pneumonia) and community-acquired pneumonia. It is marketed by Basilea Pharmaceutica in the United Kingdom, Germany, Switzerland and Austria under the trade name Zevtera, in France and Italy under the trade name Mabelio. Like other cephalosporins, ceftobiprole exerts its antibacterial activity by binding to important penicillin-binding proteins and inhibiting their transpeptidase activity which is essential for the synthesis of bacterial cell walls. Ceftobiprole has high affinity for penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus strains and retains its activity against strains that express divergent mecA gene homologues (mecC or mecALGA251). Ceftobiprole also binds to penicillin-binding protein 2b in Streptococcus pneumoniae (penicillin-intermediate), to penicillin-binding protein 2x in Streptococcus pneumoniae (penicillin-resistant), and to penicillin-binding protein 5 in Enterococcus faecalis.
Classification
Small molecule
Drug classcephalosporins
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Structure (InChI/SMILES or Protein Sequence)
Nc1nc(/C(=N/O)C(=O)N[C@@H]2C(=O)N3C(C(=O)O)=C(/C=C4\CCN([C@@H]5CCNC5)C4=O)CS[C@H]23)ns1
Identifiers
PDB—
CAS-ID209467-52-7
RxCUI—
ChEMBL IDCHEMBL520642
ChEBI ID—
PubChem CID6918430
DrugBankDB04918
UNII ID5T97333YZK (ChemIDplus, GSRS)
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Trends
PubMed Central
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Safety
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95 adverse events reported
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