Ceftobiprole
Zevtera (ceftobiprole) is a small molecule pharmaceutical. Ceftobiprole was first approved as Zevtera on 2024-04-03. It is used to treat bacteremia, methicillin-resistant staphylococcus aureus, and pneumonia in the USA.
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Drug
General
| Drug common name | Ceftobiprole |
| INN | ceftobiprole |
| Description | Ceftobiprole (Zevtera/Mabelio) is a fifth-generation cephalosporin for the treatment of hospital-acquired pneumonia (excluding ventilator-associated pneumonia) and community-acquired pneumonia. It is marketed by Basilea Pharmaceutica in the United Kingdom, Germany, Switzerland and Austria under the trade name Zevtera, in France and Italy under the trade name Mabelio. Like other cephalosporins, ceftobiprole exerts its antibacterial activity by binding to important penicillin-binding proteins and inhibiting their transpeptidase activity which is essential for the synthesis of bacterial cell walls. Ceftobiprole has high affinity for penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus strains and retains its activity against strains that express divergent mecA gene homologues (mecC or mecALGA251). Ceftobiprole also binds to penicillin-binding protein 2b in Streptococcus pneumoniae (penicillin-intermediate), to penicillin-binding protein 2x in Streptococcus pneumoniae (penicillin-resistant), and to penicillin-binding protein 5 in Enterococcus faecalis.
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| Classification | Small molecule |
| Drug class | cephalosporins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc(/C(=N/O)C(=O)N[C@@H]2C(=O)N3C(C(=O)O)=C(/C=C4\CCN([C@@H]5CCNC5)C4=O)CS[C@H]23)ns1 |
Identifiers
| PDB | — |
| CAS-ID | 209467-52-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL520642 |
| ChEBI ID | — |
| PubChem CID | 6918430 |
| DrugBank | DB04918 |
| UNII ID | 5T97333YZK (ChemIDplus, GSRS) |
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0 adverse events reported
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