Fortaz, Zavicefta(ceftazidime)
Avycaz, Ceftazidime, Fortaz, Tazicef, Zavicefta (ceftazidime) is a small molecule pharmaceutical. Ceftazidime was first approved as Fortaz on 1985-07-19. It is used to treat acinetobacter infections, bacterial infections, bacterial meningitis, bacterial pneumonia, and bacterial skin diseases amongst others in the USA. It has been approved in Europe to treat bacterial pneumonia, gram-negative bacterial infections, pneumonia, soft tissue infections, and urinary tract infections.
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Tazicef (discontinued: Ceftazidime, Ceptaz, Fortaz, Pentacef, Tazicef, Tazidime)
CombinationsAvycaz
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ceftazidime
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CEFTAZIDIME IN DEXTROSE CONTAINER | B. Braun Medical | N-050823 DISCN | 2011-06-13 | 2 products, RLD |
| CEPTAZ | GSK | N-050646 DISCN | 1990-09-27 | 4 products |
| FORTAZ | PAI Pharma | N-050578 DISCN | 1985-07-19 | 4 products, RLD |
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Avibactam sodium
+
Ceftazidime
Ceftazidime sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| FORTAZ IN PLASTIC CONTAINER | PAI Pharma | N-050634 DISCN | 1989-04-28 | 3 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| avycaz | New Drug Application | 2024-01-26 |
| ceftazidime | ANDA | 2024-01-03 |
| fortamet | New Drug Application | 2010-03-15 |
| fortaz | New Drug Application | 2017-07-28 |
| tazicef | ANDA | 2024-07-04 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
AVIBACTAM SODIUM / CEFTAZIDIME, AVYCAZ, ALLERGAN | |||
| 2025-12-20 | NPP | ||
| 2025-02-25 | GAIN | ||
| 2020-02-25 | NCE | ||
Clinical
Clinical Trials
129 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 1 | 8 | 10 | 7 | 18 | 43 |
| Communicable diseases | D003141 | — | — | 1 | 6 | 9 | 5 | 14 | 34 |
| Pneumonia | D011014 | EFO_0003106 | — | 2 | 2 | 5 | 3 | 6 | 18 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | 4 | 3 | 1 | 3 | 11 |
| Fibrosis | D005355 | — | — | — | 1 | 1 | 6 | 3 | 10 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 1 | — | — | 6 | 3 | 10 |
| Intraabdominal infections | D059413 | — | — | — | 2 | 5 | 1 | 2 | 10 |
| Healthcare-associated pneumonia | D000077299 | — | — | 1 | 1 | 2 | 3 | 2 | 9 |
| Bacterial infections | D001424 | — | A49 | 1 | 2 | — | 1 | 5 | 8 |
| Enterobacteriaceae infections | D004756 | EFO_1001313 | — | — | — | 2 | 2 | 4 | 8 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Keratitis | D007634 | HP_0000491 | H16 | — | 1 | 1 | — | 2 | 3 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | 1 | — | — | 1 |
| Ascites | D001201 | HP_0001541 | R18 | — | 1 | 1 | — | — | 1 |
| Esophageal achalasia | D004931 | HP_0002571 | K22.0 | — | 1 | 1 | — | — | 1 |
| Staphylococcal skin infections | D013207 | EFO_1001849 | L00 | — | — | 1 | — | — | 1 |
| Infectious skin diseases | D012874 | — | — | — | — | 1 | — | — | 1 |
| Bacterial skin diseases | D017192 | — | — | — | — | 1 | — | — | 1 |
| Skin diseases | D012871 | — | L00-L99 | — | — | 1 | — | — | 1 |
| Cellulitis | D002481 | EFO_0003035 | L03.90 | — | — | 1 | — | — | 1 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Meningitis | D008581 | HP_0001287 | G03 | — | 1 | — | — | 1 | 2 |
| Melioidosis | D008554 | — | A24.9 | — | 1 | — | — | 1 | 2 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | 1 | — | — | — | 1 |
| Respiratory tract infections | D012141 | — | J06.9 | — | 1 | — | — | — | 1 |
| Pseudomonas infections | D011552 | EFO_0001076 | A41.52 | — | 1 | — | — | — | 1 |
| Bronchiectasis | D001987 | HP_0002110 | J47 | — | 1 | — | — | — | 1 |
| Anaphylaxis | D000707 | — | T88.6 | — | 1 | — | — | — | 1 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | 1 | — | — | — | 1 |
| Drug hypersensitivity | D004342 | EFO_0009482 | T88.7 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | — | — | — | — | 6 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic kidney failure | D007676 | EFO_0003884 | N18.9 | — | — | — | — | 3 | 3 |
| Endophthalmitis | D009877 | — | — | — | — | — | — | 2 | 2 |
| Appendicitis | D001064 | EFO_0007149 | K37 | — | — | — | — | 2 | 2 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | — | — | 1 | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
| Covid-19 | D000086382 | — | — | — | — | — | — | 1 | 1 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | — | — | — | 1 | 1 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 1 | 1 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ceftazidime |
| INN | ceftazidime |
| Description | Ceftazidime is a third-generation cephalosporin antibiotic bearing pyridinium-1-ylmethyl and {[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It has a role as an antibacterial drug, an EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor and a drug allergen. It is a cephalosporin and an oxime O-ether. It is a conjugate acid of a ceftazidime(1-). |
| Classification | Small molecule |
| Drug class | cephalosporins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(O/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccccc3)CS[C@H]12)c1csc(N)n1)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 72558-82-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL44354 |
| ChEBI ID | 3508 |
| PubChem CID | 5481173 |
| DrugBank | DB00438 |
| UNII ID | DZR1ENT301 (ChemIDplus, GSRS) |
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Zavicefta – Pfizer
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Avycaz – Allergan
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Avycaz – Warner Chilcott
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Ceftazidime
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Safety
Black-box Warning
Black-box warning for: Fortamet
Adverse Events
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8,274 adverse events reported
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