Cefpodoxime
Cefpodoxime Proxetil (cefpodoxime) is a small molecule pharmaceutical. Cefpodoxime was first approved as Vantin on 1992-08-07. It is used to treat community-acquired infections, cystitis, escherichia coli infections, gonorrhea, and haemophilus infections amongst others in the USA.
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Brand Name | Status | Last Update |
|---|---|---|
| cefpodoxime proxetil | ANDA | 2024-10-10 |
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17 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | — | 1 | 1 | 1 | 3 |
| Communicable diseases | D003141 | — | — | — | — | 1 | 1 | — | 2 |
| Otitis media | D010033 | EFO_0004992 | H66.9 | — | — | — | 1 | — | 1 |
| Otitis | D010031 | — | — | — | — | — | 1 | — | 1 |
| Otitis media with effusion | D010034 | EFO_0007415 | H65.3 | — | — | — | 1 | — | 1 |
| Pulmonary infarction | D054060 | EFO_1001408 | — | — | — | — | 1 | — | 1 |
| Soft tissue infections | D018461 | — | — | — | — | — | 1 | — | 1 |
| Gastroenteritis | D005759 | EFO_1001463 | K52.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nephrolithiasis | D053040 | — | N20.0 | — | — | 1 | — | 1 | 2 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | — | 1 | — | 1 | 2 |
| Sinusitis | D012852 | EFO_0007486 | J32 | — | — | 1 | — | — | 1 |
| Rhinosinusitis | D000096825 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | 1 | — | — | 1 | 2 |
| Anaphylaxis | D000707 | — | T88.6 | — | 1 | — | — | — | 1 |
| Drug hypersensitivity | D004342 | EFO_0009482 | T88.7 | — | 1 | — | — | — | 1 |
| Cephalosporin resistance | D018550 | — | Z16.19 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 3 | — | — | — | — | 3 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 1 | — | — | — | — | 1 |
| Diarrhea | D003967 | HP_0002014 | R19.7 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | — | — | 2 | 2 |
| Microbiota | D064307 | — | — | — | — | — | — | 1 | 1 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | — | 1 | 1 |
| Blister | D001768 | — | — | — | — | — | — | 1 | 1 |
| Nut hypersensitivity | D021184 | EFO_1001066 | — | — | — | — | — | 1 | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
| Traumatic brain injuries | D000070642 | — | S06 | — | — | — | — | 1 | 1 |
| Brain injuries | D001930 | — | S06.9 | — | — | — | — | 1 | 1 |
| Aphasia | D001037 | HP_0002381 | R47.01 | — | — | — | — | 1 | 1 |
| Anomia | D000849 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cefpodoxime |
| INN | cefpodoxime |
| Description | Cefpodoxime is a third-generation cephalosporin antibiotic with methoxymethyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamino substituents at positions 3 and 7, respectively, of the cephem skeleton. Given by mouth as its proxetil ester prodrug, it is used to treat acute otitis media, pharyngitis, and sinusitis. It has a role as an antibacterial drug. It is a cephalosporin and a carboxylic acid. |
| Classification | Small molecule |
| Drug class | cephalosporins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)/C(=N\OC)c3csc(N)n3)[C@H]2SC1 |
Identifiers
| PDB | — |
| CAS-ID | 80210-62-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1672 |
| ChEBI ID | 3504 |
| PubChem CID | 6335986 |
| DrugBank | DB01416 |
| UNII ID | 7R4F94TVGY (ChemIDplus, GSRS) |
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Cefpodoxime
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Safety
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1,105 adverse events reported
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