Cefotaxime
Claforan (cefotaxime) is a small molecule pharmaceutical. Cefotaxime was first approved as Claforan on 1982-01-01. It is used to treat acinetobacter infections, bacterial infections, bacterial meningitis, bacterial pneumonia, and bacterial skin diseases amongst others in the USA.
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Cefotaxime sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CEFOTAXIME AND DEXTROSE 2.4% IN PLASTIC CONTAINER | B. Braun Medical | N-050792 DISCN | 2004-07-29 | 1 products |
| CEFOTAXIME AND DEXTROSE 3.9% IN PLASTIC CONTAINER | B. Braun Medical | N-050792 DISCN | 2004-07-29 | 1 products |
| CLAFORAN | Validus Pharmaceuticals | N-050547 DISCN | 1982-01-01 | 4 products, RLD |
| CLAFORAN IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER | Validus Pharmaceuticals | N-050596 DISCN | 1985-05-20 | 1 products |
| CLAFORAN IN DEXTROSE 5% IN PLASTIC CONTAINER | Validus Pharmaceuticals | N-050596 DISCN | 1985-05-20 | 1 products |
| CLAFORAN IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER | Validus Pharmaceuticals | N-050596 DISCN | 1985-05-20 | 1 products |
| CLAFORAN IN DEXTROSE 5% IN PLASTIC CONTAINER | Validus Pharmaceuticals | N-050596 DISCN | 1985-05-20 | 1 products |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cefotaxime | ANDA | 2024-04-11 |
Indications
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Agency Specific
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HCPCS
Code | Description |
|---|---|
| J0698 | Injection, cefotaxime sodium, per gm |
Clinical
Clinical Trials
70 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | 4 | 8 | 13 |
| Communicable diseases | D003141 | — | — | — | 1 | — | 3 | 7 | 11 |
| Pneumonia | D011014 | EFO_0003106 | — | — | — | 1 | 2 | 4 | 7 |
| Peritonitis | D010538 | EFO_0008588 | K65 | — | — | 2 | 1 | 3 | 6 |
| Critical illness | D016638 | — | — | — | — | 1 | 1 | 3 | 5 |
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | — | 1 | 2 | 1 | 4 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | 1 | 1 | — | 3 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | — | 2 | 1 | 3 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | 2 | — | 2 |
| Fibrosis | D005355 | — | — | — | — | — | 2 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | 3 | — | 4 | 7 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | 1 | 1 | — | 1 | 3 |
| Lung diseases | D008171 | HP_0002088 | J98.4 | — | 2 | 1 | — | — | 2 |
| Toxemia | D014115 | — | — | — | — | 1 | — | 1 | 2 |
| Surgical wound infection | D013530 | — | — | — | — | 1 | — | 1 | 2 |
| Antibiotic prophylaxis | D019072 | — | — | — | — | 1 | — | 1 | 2 |
| Mycobacterium infections | D009164 | — | A31.9 | — | 1 | 1 | — | — | 1 |
| Enterobacteriaceae infections | D004756 | EFO_1001313 | — | — | — | 1 | — | — | 1 |
| Bacterial drug resistance | D024881 | — | — | — | — | 1 | — | — | 1 |
| Septic shock | D012772 | — | A48.3 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Appendicitis | D001064 | EFO_0007149 | K37 | — | 1 | — | — | 4 | 5 |
| Wound infection | D014946 | — | — | — | 1 | — | — | — | 1 |
| Endometritis | D004716 | EFO_1001312 | — | — | 1 | — | — | — | 1 |
| Pleural effusion | D010996 | HP_0002202 | J90 | — | 1 | — | — | — | 1 |
| Empyema | D004653 | EFO_0003097 | — | — | 1 | — | — | — | 1 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | 1 | — | — | — | 1 |
| Cerebral intraventricular hemorrhage | D000074042 | — | — | — | 1 | — | — | — | 1 |
| Bronchopulmonary dysplasia | D001997 | — | P27.8 | — | 1 | — | — | — | 1 |
| Necrotizing enterocolitis | D020345 | EFO_0003928 | K55.3 | — | 1 | — | — | — | 1 |
| Periventricular leukomalacia | D007969 | EFO_1001101 | P91.2 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial infections | D001424 | — | A49 | 1 | — | — | — | 2 | 3 |
| Brain injuries | D001930 | — | S06.9 | 1 | — | — | — | — | 1 |
| Focus groups | D017144 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Respiratory tract infections | D012141 | — | J06.9 | — | — | — | — | 6 | 6 |
| Pregnancy complications | D011248 | — | — | — | — | — | — | 1 | 1 |
| Infectious pregnancy complications | D011251 | — | — | — | — | — | — | 1 | 1 |
| Neonatal sepsis | D000071074 | HP_0040187 | — | — | — | — | — | 1 | 1 |
| Continuous renal replacement therapy | D000079664 | — | — | — | — | — | — | 1 | 1 |
| Penicillin resistance | D010403 | — | — | — | — | — | — | 1 | 1 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | — | 1 | 1 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | — | — | — | 1 | 1 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | — | — | — | — | 1 | 1 |
| Fistula | D005402 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cefotaxime |
| INN | cefotaxime |
| Description | (6R,7R)-3-(acetyloxymethyl)-7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is a cephalosporin. |
| Classification | Small molecule |
| Drug class | cephalosporins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(COC(C)=O)CS[C@H]12)c1csc(N)n1 |
Identifiers
| PDB | — |
| CAS-ID | 63527-52-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1730 |
| ChEBI ID | 204928 |
| PubChem CID | 5479527 |
| DrugBank | DB00493 |
| UNII ID | N2GI8B1GK7 (ChemIDplus, GSRS) |
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Safety
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3,596 adverse events reported
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