Cefoperazone
Cefobid (cefoperazone) is a small molecule pharmaceutical. Cefoperazone was first approved as Cefobid on 1982-11-18. It is used to treat bacterial infections, bacterial pneumonia, bacterial skin diseases, escherichia coli infections, and female genital diseases amongst others in the USA.
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Commercial
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Agency Specific
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HCPCS
Code | Description |
|---|---|
| S0021 | Injection, cefoperazone sodium, 1 gram |
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | 2 | 2 | 5 |
| Communicable diseases | D003141 | — | — | — | 1 | — | 2 | 2 | 5 |
| Cholangitis | D002761 | HP_0030151 | K83.0 | — | — | — | 1 | 1 | 2 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | — | — | — | 1 | 1 | 2 |
| Hemostatic disorders | D020141 | — | — | — | — | — | 1 | 1 | 2 |
| Biliary liver cirrhosis | D008105 | — | K74.3 | — | — | — | 1 | — | 1 |
| Patient compliance | D010349 | — | — | — | — | — | 1 | — | 1 |
| Antibody specificity | D000918 | — | — | — | — | — | 1 | — | 1 |
| Pancreatitis | D010195 | HP_0001733 | K85 | — | — | — | 1 | — | 1 |
| Acute necrotizing pancreatitis | D019283 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pneumonia | D011014 | EFO_0003106 | — | 1 | 1 | — | — | 1 | 2 |
| Respiratory tract infections | D012141 | — | J06.9 | — | 1 | — | — | — | 1 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Critical illness | D016638 | — | — | — | — | — | — | 1 | 1 |
| Rectal neoplasms | D012004 | — | — | — | — | — | — | 1 | 1 |
| Healthcare-associated pneumonia | D000077299 | — | — | — | — | — | — | 1 | 1 |
| Appendicitis | D001064 | EFO_0007149 | K37 | — | — | — | — | 1 | 1 |
| Wound infection | D014946 | — | — | — | — | — | — | 1 | 1 |
| Cholecystitis | D002764 | HP_0001082 | K81 | — | — | — | — | 1 | 1 |
| Peritonitis | D010538 | EFO_0008588 | K65 | — | — | — | — | 1 | 1 |
| Abdominal abscess | D018784 | EFO_1001753 | — | — | — | — | — | 1 | 1 |
| Risk factors | D012307 | EFO_0003919 | — | — | — | — | — | 1 | 1 |
| Biliary atresia | D001656 | EFO_0004217 | Q44.2 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cefoperazone |
| INN | cefoperazone |
| Description | (6R,7R)-7-[(2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)(hydroxy)methylidene]amino}-1-hydroxy-2-(4-hydroxyphenyl)ethylidene)amino]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is a peptide. |
| Classification | Small molecule |
| Drug class | cephalosporins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN1CCN(C(=O)N[C@@H](C(=O)N[C@@H]2C(=O)N3C(C(=O)O)=C(CSc4nnnn4C)CS[C@H]23)c2ccc(O)cc2)C(=O)C1=O |
Identifiers
| PDB | — |
| CAS-ID | 62893-19-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL507674 |
| ChEBI ID | 3493 |
| PubChem CID | 44185 |
| DrugBank | DB01329 |
| UNII ID | 7U75I1278D (ChemIDplus, GSRS) |
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1,550 adverse events reported
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