Cefazolin
Cefazolin (cefazolin) is a small molecule pharmaceutical. Cefazolin was first approved as Ancef on 1982-01-01. It is used to treat bacterial endocarditis, bacterial infections, bacterial pneumonia, bacterial skin diseases, and escherichia coli infections amongst others in the USA.
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Abbreviated New Drug Application (ANDA)
Cefazolin sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CEFAZOLIN AND DEXTROSE | B. Braun Medical | N-050779 RX | 2000-07-27 | 2 products, RLD, RS |
| CEFAZOLIN IN PLASTIC CONTAINER | Baxter | N-207131 RX | 2015-08-07 | 2 products, RLD, RS |
| CEFAZOLIN SODIUM | Hikma Pharmaceuticals | N-216109 RX | 2022-10-07 | 2 products, RLD, RS |
| CEFAZOLIN SODIUM | HQ Specialty Pharma | N-211413 RX | 2023-05-08 | 1 products, RLD, RS |
Show 4 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| antiseptic skin cleanser | New Drug Application | 2024-02-13 |
| cefazolin | ANDA | 2024-01-15 |
| cefazolin sodium | New Drug Application | 2021-07-14 |
| rugby petrolatum hydrating | C200263 | 2024-02-12 |
Indications
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Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
CEFAZOLIN SODIUM, CEFAZOLIN AND DEXTROSE, B BRAUN | |||
| 2023-11-23 | NPP | ||
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Clinical
Clinical Trials
227 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Surgical wound infection | D013530 | — | — | 2 | 2 | 4 | 11 | 7 | 24 |
| Infections | D007239 | EFO_0000544 | — | 4 | 1 | 3 | 4 | 7 | 18 |
| Wound infection | D014946 | — | — | — | — | — | 5 | 5 | 10 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | 3 | 2 | 2 | 1 | 8 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 2 | — | — | 4 | — | 6 |
| Antibiotic prophylaxis | D019072 | — | — | — | — | — | 2 | 4 | 6 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | — | — | 1 | 3 | — | 4 |
| Staphylococcal infections | D013203 | — | A49.01 | — | — | 1 | 2 | 1 | 4 |
| Endometritis | D004716 | EFO_1001312 | — | — | — | — | 1 | 2 | 3 |
| Infectious arthritis | D001170 | EFO_1001351 | M00 | — | — | — | 3 | — | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | HP_0100806 | A41.9 | 1 | 1 | 2 | — | — | 3 |
| Cellulitis | D002481 | EFO_0003035 | L03.90 | — | 1 | 1 | — | 1 | 3 |
| Keratitis | D007634 | HP_0000491 | H16 | — | — | 1 | — | 1 | 2 |
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | 1 | 2 |
| Premature rupture fetal membranes | D005322 | HP_0001788 | O42 | — | — | 1 | — | 1 | 2 |
| Infectious skin diseases | D012874 | — | — | — | — | 1 | — | — | 1 |
| Bacterial skin diseases | D017192 | — | — | — | — | 1 | — | — | 1 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | — | 1 | — | — | 1 |
| Chronic pancreatitis | D050500 | EFO_0000342 | K86.1 | — | — | 1 | — | — | 1 |
| Hemopneumothorax | D006468 | EFO_1000963 | J94.2 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Endocarditis | D004696 | HP_0100584 | — | — | 1 | — | — | 1 | 2 |
| Hyperglycemia | D006943 | HP_0003074 | R73.9 | — | 1 | — | — | — | 1 |
| Critical illness | D016638 | — | — | — | 1 | — | — | — | 1 |
| Fever | D005334 | HP_0001945 | R50.9 | — | 1 | — | — | — | 1 |
| Pneumonia | D011014 | EFO_0003106 | — | — | 1 | — | — | — | 1 |
| Cross infection | D003428 | — | — | — | 1 | — | — | — | 1 |
| Systemic inflammatory response syndrome | D018746 | EFO_1001478 | R65.10 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mammaplasty | D016462 | — | — | 1 | — | — | — | 2 | 3 |
| Renal replacement therapy | D017582 | — | — | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 4 | 4 |
| Appendicitis | D001064 | EFO_0007149 | K37 | — | — | — | — | 3 | 3 |
| Acute cholecystitis | D041881 | EFO_1001289 | K81.0 | — | — | — | — | 2 | 2 |
| Hysterectomy | D007044 | EFO_0003881 | — | — | — | — | — | 2 | 2 |
| Closed fractures | D005596 | — | — | — | — | — | — | 2 | 2 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 1 | 1 |
| Pregnancy rate | D018873 | — | — | — | — | — | — | 1 | 1 |
| Dentofacial deformities | D063169 | — | — | — | — | — | — | 1 | 1 |
| Insulin resistance | D007333 | HP_0000855 | E88.819 | — | — | — | — | 1 | 1 |
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | — | — | — | — | 1 | 1 |
Show 35 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cefazolin |
| INN | cefazolin |
| Description | Cefazolin is a first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively. It has a role as an antibacterial drug. It is a cephalosporin, a member of thiadiazoles, a member of tetrazoles and a beta-lactam antibiotic allergen. It is a conjugate acid of a cefazolin(1-). |
| Classification | Small molecule |
| Drug class | cephalosporins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1nnc(SCC2=C(C(=O)O)N3C(=O)[C@@H](NC(=O)Cn4cnnn4)[C@H]3SC2)s1 |
Identifiers
| PDB | — |
| CAS-ID | 25953-19-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1435 |
| ChEBI ID | 474053 |
| PubChem CID | 33255 |
| DrugBank | DB01327 |
| UNII ID | IHS69L0Y4T (ChemIDplus, GSRS) |
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Cefazolin
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4,528 adverse events reported
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