Cediranib
Cediranib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against vascular endothelial growth factor receptor 1, mast/stem cell growth factor receptor Kit, vascular endothelial growth factor receptor 3, platelet-derived growth factor receptor beta, vascular endothelial growth factor receptor 2, and platelet-derived growth factor receptor alpha. In addition, it is known to target receptor-type tyrosine-protein kinase FLT3 and macrophage colony-stimulating factor 1 receptor.
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Commercial
Therapeutic Areas
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Trade Name
FDA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Indications
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Agency Specific
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Clinical
Clinical Trials
105 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | 5 | 2 | — | 1 | 9 |
| Colorectal neoplasms | D015179 | — | — | 1 | 4 | 2 | — | — | 5 |
| Ovarian epithelial carcinoma | D000077216 | — | — | — | 3 | 1 | — | 1 | 5 |
| Recurrence | D012008 | — | — | 1 | 2 | 1 | — | — | 4 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 1 | 1 | — | — | 3 |
| Fallopian tube neoplasms | D005185 | — | — | 1 | — | 1 | — | — | 2 |
| Endometrioid carcinoma | D018269 | — | — | — | — | 1 | — | — | 1 |
| Mucinous cystadenocarcinoma | D018282 | — | — | — | — | 1 | — | — | 1 |
| Acinar cell carcinoma | D018267 | — | — | — | — | 1 | — | — | 1 |
| Biliary tract neoplasms | D001661 | — | C24.9 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 13 | 3 | — | — | — | 16 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 2 | — | — | — | 4 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 4 | 1 | — | — | — | 4 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | — | 2 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | 1 | 1 | — | — | — | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 2 | — | — | — | 2 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 1 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | — | — | — | 2 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | 1 | — | — | — | 2 |
| Leiomyosarcoma | D007890 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rectal neoplasms | D012004 | — | — | 1 | — | — | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | — | — | — | — | 1 |
| Uterine cervical neoplasms | D002583 | — | — | 1 | — | — | — | — | 1 |
| Peritoneal neoplasms | D010534 | — | — | 1 | — | — | — | — | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | — | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cediranib |
| INN | cediranib |
| Description | 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline is an aromatic ether. |
| Classification | Small molecule |
| Drug class | angiogenesis inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 |
Identifiers
| PDB | — |
| CAS-ID | 288383-20-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL491473 |
| ChEBI ID | — |
| PubChem CID | 9933475 |
| DrugBank | — |
| UNII ID | NQU9IPY4K9 (ChemIDplus, GSRS) |
Target
Agency Approved
FLT1
FLT1
KIT
KIT
FLT4
FLT4
PDGFRB
PDGFRB
KDR
KDR
PDGFRA
PDGFRA
Organism
Homo sapiens
Gene name
FLT1
Gene synonyms
FLT, FRT, VEGFR1
NCBI Gene ID
Protein name
vascular endothelial growth factor receptor 1
Protein synonyms
FLT, FLT-1, fms related tyrosine kinase 1, Fms-like tyrosine kinase 1, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor
Uniprot ID
Mouse ortholog
Flt1 (14254)
vascular endothelial growth factor receptor 1 (Q61517)
Alternate
FLT3
FLT3
CSF1R
CSF1R
Organism
Homo sapiens
Gene name
FLT3
Gene synonyms
CD135, FLK2, STK1
NCBI Gene ID
Protein name
receptor-type tyrosine-protein kinase FLT3
Protein synonyms
CD135, CD135 antigen, fetal liver kinase 2, Fetal liver kinase-2, FL cytokine receptor, FLK-2, FLT-3, fms related tyrosine kinase 3, Fms-like tyrosine kinase 3, growth factor receptor tyrosine kinase type III, Stem cell tyrosine kinase 1, STK-1
Uniprot ID
Mouse ortholog
Flt3 (14255)
receptor-type tyrosine-protein kinase FLT3 (Q00342)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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159 adverse events reported
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