Cebranopadol
Cebranopadol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target mu-type opioid receptor, delta-type opioid receptor, nociceptin receptor, and kappa-type opioid receptor.
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Commercial
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Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic pain | D059350 | — | — | — | 2 | 2 | — | — | 4 |
| Pain | D010146 | EFO_0003843 | R52 | 1 | 1 | 2 | — | — | 4 |
| Neoplasms | D009369 | — | C80 | — | — | 2 | — | — | 2 |
| Acute pain | D059787 | — | R52 | — | — | 2 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | 3 | — | — | — | 3 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 2 | — | — | — | 2 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 2 | — | — | — | 2 |
| Polyneuropathies | D011115 | EFO_0009562 | A69.22 | — | 2 | — | — | — | 2 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 1 | — | — | — | 1 |
| Low back pain | D017116 | — | M54.5 | — | 1 | — | — | — | 1 |
| Back pain | D001416 | — | M54 | — | 1 | — | — | — | 1 |
| Postoperative pain | D010149 | — | G89.18 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 2 | — | — | — | — | 2 |
| Hypercapnia | D006935 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cebranopadol |
| INN | cebranopadol |
| Description | Cebranopadol (developmental code GRT-6005) is an opioid analgesic of the benzenoid class which is currently under development internationally by Grünenthal, a German pharmaceutical company, and its partner Depomed, a pharmaceutical company in the United States, for the treatment of a variety of different acute and chronic pain states. As of November 2014, it is in phase III clinical trials.
|
| Classification | Small molecule |
| Drug class | analgesics (mixed opiate receptor agonists/antagonists) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)[C@]1(c2ccccc2)CC[C@]2(CC1)OCCc1c3cc(F)ccc3[nH]c12 |
Identifiers
| PDB | — |
| CAS-ID | 863513-91-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2364605 |
| ChEBI ID | — |
| PubChem CID | 11848225 |
| DrugBank | DB12830 |
| UNII ID | 7GDW9S3GN3 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
OPRM1
OPRM1
OPRD1
OPRD1
OPRL1
OPRL1
OPRK1
OPRK1
Variants
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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