Caspofungin - PharmaKB

Cancidas, Cancidas (previously caspofungin msd)(caspofungin)

Cancidas (caspofungin) is a small molecule pharmaceutical. Caspofungin was first approved as Cancidas on 2001-01-26. It is used to treat aspergillosis, candidemia, and mycoses in the USA. It has been approved in Europe to treat aspergillosis and candidiasis.

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Clinical

Drug

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Variants

Financial

Trends

Safety

Events Timeline

YTD

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Events

FDA approval date

EMA approval date

Patent expiration date

Study first post date

Last update post date

Start date

Primary completion date

Completion date

Results first post date

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Commercial

Therapeutic Areas

Therapeutic Area	MeSH
infections	D007239
signs and symptoms pathological conditions	D013568

Trade Name

FDA

EMA

Cancidas, Caspofungin (discontinued: Caspofungin)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Caspofungin acetate

Tradename	Company	Number	Date	Products
CASPOFUNGIN ACETATE	Fresenius Kabi	N-206110 RX	2016-12-30	2 products
CANCIDAS	Merck & Co	N-021227 RX	2001-01-26	2 products, RLD, RS

Labels

FDA

EMA

Brand Name	Status	Last Update
cancidas	New Drug Application	2024-10-11
caspofungin acetate	ANDA	2024-10-15

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
candidemia	EFO_1001282	D058387	—
mycoses	—	D009181	B35-B49
aspergillosis	EFO_0007157	D001228	B44

Agency Specific

FDA

EMA

No data

Patent Expiration

Patent	Expires	Flag	FDA Information
Caspofungin Acetate, Caspofungin Acetate, Fresenius Kabi Usa
9636407	2032-12-21	DP

ATC Codes

J: Antiinfectives for systemic use

— J02: Antimycotics for systemic use

— J02A: Antimycotics for systemic use

— J02AX: Other antimycotics for systemic use in atc

— J02AX04: Caspofungin

HCPCS

Code	Description
J0637	Injection, caspofungin acetate, 5 mg

Clinical

Clinical Trials

86 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Mycoses	D009181	—	B35-B49	—	9	11	3	10	33
Candidiasis	D002177	—	B37	—	9	14	2	6	31
Invasive candidiasis	D058365	EFO_1001283	B37	—	5	8	2	2	17
Invasive fungal infections	D000072742	—	—	—	3	2	1	7	13
Aspergillosis	D001228	EFO_0007157	B44	1	7	1	2	3	13
Candidemia	D058387	EFO_1001282	—	—	2	6	1	3	12
Invasive pulmonary aspergillosis	D055744	—	B44.0	1	3	—	2	1	6
Critical illness	D016638	—	—	—	—	—	1	4	5
Liver transplantation	D016031	EFO_0010682	—	—	1	1	1	—	3
Pneumocystis pneumonia	D011020	EFO_0007448	B59	—	—	1	1	1	3

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Infections	D007239	EFO_0000544	—	—	3	7	—	10	20
Neutropenia	D009503	—	D70	—	2	5	—	3	10
Communicable diseases	D003141	—	—	—	1	4	—	3	8
Leukemia	D007938	—	C95	1	3	2	—	1	6
Fungemia	D016469	—	B49	—	2	3	—	—	5
Neoplasms	D009369	—	C80	—	2	2	—	—	4
Myeloid leukemia acute	D015470	—	C92.0	1	1	1	—	—	2
Myeloid leukemia	D007951	—	C92	1	1	1	—	—	2
Oral candidiasis	D002180	EFO_0007406	B37.0	—	1	1	—	—	2
Pneumocystis	D011010	—	—	—	—	1	—	—	1

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Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Fever	D005334	HP_0001945	R50.9	—	1	—	—	2	3
Sepsis	D018805	HP_0100806	A41.9	—	1	—	—	1	2
Hematopoietic stem cell transplantation	D018380	—	—	—	2	—	—	—	2
Hiv infections	D015658	EFO_0000764	B20	—	1	—	—	1	2
Agranulocytosis	D000380	HP_0012234	D70	—	1	—	—	—	1
Intestinal perforation	D007416	EFO_1000987	P78.0	—	1	—	—	—	1

Indications Phases 1

No data

Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Hypoalbuminemia	D034141	HP_0003073	—	—	—	—	—	1	1
Fusariosis	D060585	EFO_1001795	—	—	—	—	—	1	1
Febrile neutropenia	D064147	—	—	—	—	—	—	1	1
Hyperthermia	D000084462	—	—	—	—	—	—	1	1
Sarcoma	D012509	—	—	—	—	—	—	1	1
Lymphoma	D008223	—	C85.9	—	—	—	—	1	1
Neuroblastoma	D009447	EFO_0000621	—	—	—	—	—	1	1
Kidney neoplasms	D007680	EFO_0003865	C64	—	—	—	—	1	1
Hot flashes	D019584	—	—	—	—	—	—	1	1
Esophagitis	D004941	HP_0100633	K20	—	—	—	—	1	1

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Caspofungin
INN	caspofungin
Description	Caspofungin (INN; brand name Cancidas) is a lipopeptide antifungal drug from Merck & Co., Inc.. It is a member of a class of antifungals termed the echinocandins. It works by inhibiting the enzyme (1→3)-β-D-glucan synthase and thereby disturbing the integrity of the fungal cell wall.
Classification	Small molecule
Drug class	antifungal antibiotics (undefined group)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CCC(C)CC(C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O