Cancidas, Cancidas (previously caspofungin msd)(caspofungin)
Cancidas, Caspofungin (caspofungin) is a small molecule pharmaceutical. Caspofungin was first approved as Cancidas on 2001-01-26. It is used to treat aspergillosis, candidemia, and mycoses in the USA. It has been approved in Europe to treat aspergillosis and candidiasis.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Caspofungin (discontinued: Cancidas, Caspofungin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Caspofungin acetate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CASPOFUNGIN ACETATE | Fresenius Kabi | N-206110 RX | 2016-12-30 | 2 products |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cancidas | New Drug Application | 2024-10-11 |
| caspofungin acetate | ANDA | 2024-11-20 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| candidemia | EFO_1001282 | D058387 | — |
| mycoses | — | D009181 | B35-B49 |
| aspergillosis | EFO_0007157 | D001228 | B44 |
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Caspofungin Acetate, Caspofungin Acetate, Fresenius Kabi Usa | |||
| 9636407 | 2032-12-21 | DP | |
HCPCS
Code | Description |
|---|---|
| J0637 | Injection, caspofungin acetate, 5 mg |
Clinical
Clinical Trials
87 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Candidiasis | D002177 | — | B37 | — | 7 | 2 | 1 | 1 | 11 |
| Invasive candidiasis | D058365 | EFO_1001283 | B37 | — | 3 | 2 | 1 | — | 6 |
| Aspergillosis | D001228 | EFO_0007157 | B44 | — | 3 | 1 | 1 | — | 5 |
| Invasive pulmonary aspergillosis | D055744 | — | B44.0 | — | — | — | 1 | — | 1 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | 1 | — | 1 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | — | — | — | 1 | — | 1 |
| Obstructive lung diseases | D008173 | — | — | — | — | — | 1 | — | 1 |
| Pulmonary aspergillosis | D055732 | EFO_1001834 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mycoses | D009181 | — | B35-B49 | — | 5 | 4 | — | — | 9 |
| Neutropenia | D009503 | — | D70 | — | 2 | 2 | — | — | 4 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | 1 | — | — | 2 |
| Communicable diseases | D003141 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | — | — | 1 | 2 |
| Fungemia | D016469 | — | B49 | — | 1 | — | — | — | 1 |
| Invasive fungal infections | D000072742 | — | — | — | 1 | — | — | — | 1 |
| Liver transplantation | D016031 | EFO_0010682 | — | — | 1 | — | — | — | 1 |
| Hematopoietic stem cell transplantation | D018380 | — | — | — | 1 | — | — | — | 1 |
| Fever | D005334 | — | R50.9 | — | 1 | — | — | — | 1 |
| Oral candidiasis | D002180 | EFO_0007406 | B37.0 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Candidemia | D058387 | EFO_1001282 | — | — | — | — | — | 1 | 1 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | — | — | — | 1 | 1 |
| Shock | D012769 | — | R57.1 | — | — | — | — | 1 | 1 |
| Esophagitis | D004941 | HP_0100633 | K20 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Caspofungin |
| INN | caspofungin |
| Description | Caspofungin (INN; brand name Cancidas) is a lipopeptide antifungal drug from Merck & Co., Inc.. It is a member of a class of antifungals termed the echinocandins. It works by inhibiting the enzyme (1→3)-β-D-glucan synthase and thereby disturbing the integrity of the fungal cell wall.
|
| Classification | Small molecule |
| Drug class | antifungal antibiotics (undefined group) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCC(C)CC(C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O |
Identifiers
| PDB | — |
| CAS-ID | 162808-62-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL499808 |
| ChEBI ID | 474180 |
| PubChem CID | 16119814 |
| DrugBank | DB00520 |
| UNII ID | F0XDI6ZL63 (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
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Cancidas – Merck & Co
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Estimated US medical usage
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 12,210 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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5,576 adverse events reported
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