Carvedilol
Carvedilol, Coreg (carvedilol) is a small molecule pharmaceutical. Carvedilol was first approved as Coreg on 1995-09-14. It is used to treat angina pectoris, heart failure, hypertension, and myocardial infarction in the USA. The pharmaceutical is active against beta-1 adrenergic receptor and beta-2 adrenergic receptor. In addition, it is known to target ryanodine receptor 2.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Coreg (generic drugs available since 2007-09-05)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Carvedilol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COREG | Woodward Pharma Services | N-020297 RX | 1995-09-14 | 4 products, RLD |
Carvedilol phosphate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COREG CR | Woodward Pharma Services | N-022012 RX | 2006-10-20 | 4 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| antiseptic skin cleanser | New Drug Application | 2024-02-13 |
| carvedilol | ANDA | 2024-02-13 |
| carvedilol phosphate | ANDA | 2024-01-29 |
| coreg | New Drug Application | 2023-11-21 |
| coreg cr | New Drug Application | 2023-12-19 |
| coregcr | New Drug Application | 2010-09-08 |
| hypertenevide | unapproved drug other | 2010-12-08 |
| hypertenevide-12.5 | unapproved drug other | 2011-08-01 |
| rugby petrolatum hydrating | C200263 | 2024-02-12 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Carvedilol Phosphate, Coreg Cr, Woodward | |||
| 8101209 | 2025-09-11 | DP | |
HCPCS
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Clinical
Clinical Trials
288 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | HP_0001635 | I50 | 3 | 1 | 11 | 21 | 13 | 48 |
| Hypertension | D006973 | EFO_0000537 | I10 | 6 | 2 | 8 | 11 | 7 | 34 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | 2 | 6 | 16 | 24 |
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | 1 | 4 | 6 | 11 | 21 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | 3 | 2 | 6 | 11 |
| Esophageal and gastric varices | D004932 | EFO_0009545 | I85 | — | 1 | 1 | 5 | 4 | 10 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | 1 | — | — | 5 | — | 6 |
| Stable angina | D060050 | — | I20.89 | 3 | — | — | 1 | 1 | 5 |
| Dilated cardiomyopathy | D002311 | HP_0001644 | I42.0 | — | 1 | 1 | 3 | — | 5 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | 1 | 3 | — | 4 |
Show 34 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 4 | 2 | — | 1 | 8 |
| Cardiotoxicity | D066126 | EFO_1001482 | — | 1 | 1 | 2 | — | — | 4 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | 1 | 1 | — | 2 | 3 |
| Lymphoma | D008223 | — | C85.9 | — | 1 | 1 | — | — | 2 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 1 | 1 | — | — | 2 |
| Hypercholesterolemia | D006937 | HP_0003124 | — | — | — | 1 | — | — | 1 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | 1 | — | — | 1 |
| Masked hypertension | D059468 | — | — | — | — | 1 | — | — | 1 |
| Tricuspid valve insufficiency | D014262 | HP_0005180 | — | — | — | 1 | — | — | 1 |
| Abdominal obesity | D056128 | HP_0001956 | — | — | — | 1 | — | — | 1 |
Show 7 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | 1 | — | — | 2 | 3 |
| Pulmonary arterial hypertension | D000081029 | — | — | 2 | 3 | — | — | — | 3 |
| Cocaine-related disorders | D019970 | — | F14 | — | 2 | — | — | 1 | 3 |
| Secondary parkinson disease | D010302 | EFO_1001175 | G21 | — | 2 | — | — | — | 2 |
| Rem sleep behavior disorder | D020187 | EFO_0007462 | G47.52 | — | 2 | — | — | — | 2 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 1 | — | — | 1 | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | — | — | — | 1 |
| Hypoglycemia | D007003 | HP_0001943 | E16.2 | — | 1 | — | — | — | 1 |
| Cardiovascular abnormalities | D018376 | EFO_0003848 | — | — | 1 | — | — | — | 1 |
| Sarcoma | D012509 | — | — | — | 1 | — | — | — | 1 |
Show 6 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 9 | — | — | — | 2 | 11 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 3 | — | — | — | 1 | 4 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | — | — | — | — | 2 |
| Sleep deprivation | D012892 | — | F51.12 | 1 | — | — | — | 1 | 2 |
| Heart disease risk factors | D000082742 | — | — | 1 | — | — | — | — | 1 |
| Sleep wake disorders | D012893 | — | G47 | 1 | — | — | — | — | 1 |
| Sleep | D012890 | GO_0030431 | — | 1 | — | — | — | — | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 3 | 3 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 3 | 3 |
| Loneliness | D008132 | — | R45.89 | — | — | — | — | 3 | 3 |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | — | — | — | 2 | 2 |
| Mental health | D008603 | EFO_0003935 | — | — | — | — | — | 2 | 2 |
| Frailty | D000073496 | — | R53.1 | — | — | — | — | 2 | 2 |
| Acute-on-chronic liver failure | D065290 | — | — | — | — | — | — | 2 | 2 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | — | — | — | — | 2 | 2 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | — | — | — | 2 | 2 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | — | — | 2 | 2 |
Show 42 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Carvedilol |
| INN | carvedilol |
| Description | Carvedilol is a member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure. It has a role as a beta-adrenergic antagonist, an antihypertensive agent, an alpha-adrenergic antagonist, a vasodilator agent and a cardiovascular drug. It is a member of carbazoles, a secondary alcohol and a secondary amino compound. |
| Classification | Small molecule |
| Drug class | vasodilators (undefined group) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 |
Identifiers
| PDB | — |
| CAS-ID | 72956-09-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL723 |
| ChEBI ID | 3441 |
| PubChem CID | 2585 |
| DrugBank | DB01136 |
| UNII ID | 0K47UL67F2 (ChemIDplus, GSRS) |
Target
Agency Approved
Alternate
RYR2
RYR2
Organism
Homo sapiens
Gene name
RYR2
Gene synonyms
NCBI Gene ID
Protein name
ryanodine receptor 2
Protein synonyms
Cardiac muscle ryanodine receptor, Cardiac muscle ryanodine receptor-calcium release channel, cardiac-type ryanodine receptor, islet-type ryanodine receptor, kidney-type ryanodine receptor, ryanodine receptor 2 (cardiac), Type 2 ryanodine receptor
Uniprot ID
Mouse ortholog
Ryr2 (20191)
ryanodine receptor 2 (Q9ERN6)
Variants
No data
Financial
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Estimated US medical usage
Carvedilol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 33,972 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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18,773 adverse events reported
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