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Drug ReportsCarvedilol
Carvedilol
Carvedilol, Coreg (carvedilol) is a small molecule pharmaceutical. Carvedilol was first approved as Coreg on 1995-09-14. It is used to treat angina pectoris, heart failure, hypertension, and myocardial infarction in the USA. The pharmaceutical is active against beta-1 adrenergic receptor and beta-2 adrenergic receptor. In addition, it is known to target ryanodine receptor 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Carvedilol, Coreg (discontinued: Carvedilol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Carvedilol
Tradename
Company
Number
Date
Products
COREGWaylis TherapeuticsN-020297 RX1995-09-14
4 products, RLD
Carvedilol phosphate
Tradename
Company
Number
Date
Products
COREG CRWaylis TherapeuticsN-022012 RX2006-10-20
4 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
artistry beauty balm perfecting primer spf 35 broad spectrum sunscreenC2002632023-10-21
artistry exact fit longwearing foundation shade bruleC2002632023-10-21
artistry exact fit longwearing foundation shade buffC2002632023-10-21
artistry exact fit longwearing foundation shade cappuccinoC2002632023-10-22
artistry exact fit longwearing foundation shade caramelC2002632023-10-22
artistry exact fit longwearing foundation shade chablisC2002632023-10-21
artistry exact fit longwearing foundation shade chiffonC2002632023-10-21
artistry exact fit longwearing foundation shade creamC2002632023-10-21
artistry exact fit longwearing foundation shade goldenC2002632023-10-22
artistry exact fit longwearing foundation shade minkC2002632023-10-21
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Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Carvedilol Phosphate, Coreg Cr, Woodward
81012092025-09-11DP
ATC Codes
C: Cardiovascular system drugs
— C07: Beta-adrenergic blocking agents
— C07A: Beta blocking agents
— C07AG: Alpha and beta blocking agents
— C07AG02: Carvedilol
— C07F: Beta blocking agents, other combinations
— C07FX: Beta blocking agents, other combinations
— C07FX06: Carvedilol and ivabradine
HCPCS
No data
Clinical
Clinical Trials
307 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I1011918171868
Heart failureD006333HP_0001635I503312251759
Liver cirrhosisD008103EFO_0001422K74.0—3581933
Portal hypertensionD006975EFO_0000666K76.6—4771429
Esophageal and gastric varicesD004932EFO_0009545I85—1291324
FibrosisD005355———1241421
CardiomyopathiesD009202EFO_0000318I422316214
Atrial fibrillationD001281EFO_0000275I48.0——32712
Diabetes mellitusD003920HP_0000819E08-E13—115310
Heart diseasesD006331EFO_0003777I51.9111619
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C50152—19
LymphomaD008223—C85.9111——3
LeukemiaD007938—C95111——3
EpilepsyD004827EFO_0000474G40.9—11—23
Myeloid leukemia acuteD015470—C92.0—11——2
Hematopoietic stem cell transplantationD018380——1—1——2
Myeloid leukemiaD007951—C92—11——2
HypercholesterolemiaD006937HP_0003124———1——1
AtherosclerosisD050197EFO_0003914I25.1——1——1
Masked hypertensionD059468————1——1
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pulmonary arterial hypertensionD000081029——33——15
Parkinson diseaseD010300EFO_0002508G20—2——24
Mental disordersD001523EFO_0000677F91.9—2——24
AnxietyD001007EFO_0005230F41.1—1——23
Hematologic neoplasmsD019337———2——13
Familial primary pulmonary hypertensionD065627—I27.023———3
Substance-related disordersD019966EFO_0003890F13—1——23
Cocaine-related disordersD019970—F14—2——13
Secondary parkinson diseaseD010302EFO_1001175G21—2———2
Rem sleep behavior disorderD020187EFO_0007462G47.52—2———2
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———9———413
Pulmonary hypertensionD006976EFO_0001361I27.203———14
GlioblastomaD005909EFO_0000515—2————2
Circulating neoplastic cellsD009360——2————2
Sleep deprivationD012892—F51.121———12
Sickle cell anemiaD000755EFO_0000697D571————1
Heart disease risk factorsD000082742——1————1
FastingD005215EFO_0002756—1————1
Sleep wake disordersD012893—G471————1
SleepD012890GO_0030431—1————1
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382——————44
Cardiac arrhythmiasD001145EFO_0004269I49.9————33
End stage liver diseaseD058625EFO_1001311K72.1————33
Acute-on-chronic liver failureD065290——————33
LonelinessD008132—R45.89————33
Drug interactionsD004347——————22
Postpartum depressionD019052EFO_0007453F53.0————22
DepressionD003863—F33.9————22
Depressive disorderD003866EFO_1002014F32.A————22
Mental healthD008603EFO_0003935—————22
Show 71 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCarvedilol
INNcarvedilol
Description
Carvedilol is a member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure. It has a role as a beta-adrenergic antagonist, an antihypertensive agent, an alpha-adrenergic antagonist, a vasodilator agent and a cardiovascular drug. It is a member of carbazoles, a secondary alcohol and a secondary amino compound.
Classification
Small molecule
Drug classvasodilators (undefined group)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12
Identifiers
PDB—
CAS-ID72956-09-3
RxCUI—
ChEMBL IDCHEMBL723
ChEBI ID3441
PubChem CID2585
DrugBankDB01136
UNII ID0K47UL67F2 (ChemIDplus, GSRS)
Target
Agency Approved
ADRB1
ADRB1
ADRB2
ADRB2
Organism
Homo sapiens
Gene name
ADRB1
Gene synonyms
ADRB1R, B1AR
NCBI Gene ID
Protein name
beta-1 adrenergic receptor
Protein synonyms
adrenergic, beta-1-, receptor, Beta-1 adrenoceptor, Beta-1 adrenoreceptor
Uniprot ID
Mouse ortholog
Adrb1 (11554)
beta-1 adrenergic receptor (P34971)
Alternate
RYR2
RYR2
Organism
Homo sapiens
Gene name
RYR2
Gene synonyms
NCBI Gene ID
Protein name
ryanodine receptor 2
Protein synonyms
Cardiac muscle ryanodine receptor, Cardiac muscle ryanodine receptor-calcium release channel, cardiac-type ryanodine receptor, islet-type ryanodine receptor, kidney-type ryanodine receptor, ryanodine receptor 2 (cardiac), Type 2 ryanodine receptor
Uniprot ID
Mouse ortholog
Ryr2 (20191)
ryanodine receptor 2 (Q9ERN6)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Carvedilol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 35,722 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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22,445 adverse events reported
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