Carvedilol
Carvedilol, Coreg (carvedilol) is a small molecule pharmaceutical. Carvedilol was first approved as Coreg on 1995-09-14. It is used to treat angina pectoris, heart failure, hypertension, and myocardial infarction in the USA. The pharmaceutical is active against beta-1 adrenergic receptor and beta-2 adrenergic receptor. In addition, it is known to target ryanodine receptor 2.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Carvedilol, Coreg (discontinued: Carvedilol, Coreg)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Carvedilol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COREG | Waylis Therapeutics | N-020297 RX | 1995-09-14 | 4 products, RLD |
Carvedilol phosphate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COREG CR | Waylis Therapeutics | N-022012 DISCN | 2006-10-20 | 4 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| artistry beauty balm perfecting primer spf 35 broad spectrum sunscreen | C200263 | 2023-10-21 |
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| artistry exact fit longwearing foundation shade cream | C200263 | 2023-10-21 |
| artistry exact fit longwearing foundation shade golden | C200263 | 2023-10-22 |
| artistry exact fit longwearing foundation shade mink | C200263 | 2023-10-21 |
Show 58 more
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Carvedilol Phosphate, Coreg Cr, Woodward | |||
| 8101209 | 2025-09-11 | DP | |
HCPCS
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Clinical
Clinical Trials
312 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 11 | 9 | 18 | 17 | 18 | 68 |
| Heart failure | D006333 | EFO_0003144 | I50 | 3 | 3 | 12 | 25 | 17 | 59 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 3 | 5 | 8 | 19 | 33 |
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | 4 | 7 | 7 | 14 | 29 |
| Esophageal and gastric varices | D004932 | EFO_0009545 | I85 | — | 1 | 2 | 9 | 14 | 25 |
| Fibrosis | D005355 | — | — | — | 1 | 2 | 4 | 14 | 21 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | 2 | 2 | 1 | 6 | 2 | 13 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | 3 | 2 | 7 | 12 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 1 | 1 | 5 | 3 | 10 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | 1 | 1 | 1 | 6 | 1 | 9 |
Show 62 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 5 | 2 | — | 1 | 9 |
| Lymphoma | D008223 | — | C85.9 | 1 | 1 | 1 | — | — | 3 |
| Leukemia | D007938 | — | C95 | 1 | 1 | 1 | — | — | 3 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | 1 | 1 | — | 2 | 3 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 1 | 1 | — | — | 2 |
| Hematopoietic stem cell transplantation | D018380 | — | — | 1 | — | 1 | — | — | 2 |
| Myeloid leukemia | D007951 | — | C92 | — | 1 | 1 | — | — | 2 |
| Hypercholesterolemia | D006937 | — | — | — | — | 1 | — | — | 1 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | 1 | — | — | 1 |
| Masked hypertension | D059468 | — | — | — | — | 1 | — | — | 1 |
Show 18 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary arterial hypertension | D000081029 | — | — | 3 | 3 | — | — | 1 | 5 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 2 | — | — | 2 | 4 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | 2 | — | — | 2 | 4 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | 1 | — | — | 2 | 3 |
| Hematologic neoplasms | D019337 | — | — | — | 2 | — | — | 1 | 3 |
| Familial primary pulmonary hypertension | D065627 | — | I27.0 | 2 | 3 | — | — | — | 3 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 1 | — | — | 2 | 3 |
| Cocaine-related disorders | D019970 | — | F14 | — | 2 | — | — | 1 | 3 |
| Wounds and injuries | D014947 | — | T14.8 | 1 | 1 | — | — | 2 | 3 |
| Secondary parkinson disease | D010302 | EFO_1001175 | G21 | — | 2 | — | — | — | 2 |
Show 19 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 9 | — | — | — | 4 | 13 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 3 | — | — | — | 1 | 4 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | — | — | — | — | 2 |
| Circulating neoplastic cells | D009360 | — | — | 2 | — | — | — | — | 2 |
| Sleep deprivation | D012892 | — | F51.12 | 1 | — | — | — | 1 | 2 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | — | — | — | — | 1 |
| Heart disease risk factors | D000082742 | — | — | 1 | — | — | — | — | 1 |
| Fasting | D005215 | EFO_0002756 | — | 1 | — | — | — | — | 1 |
| Sleep wake disorders | D012893 | — | G47 | 1 | — | — | — | — | 1 |
| Sleep | D012890 | GO_0030431 | — | 1 | — | — | — | — | 1 |
Show 10 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 4 | 4 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 3 | 3 |
| End stage liver disease | D058625 | EFO_1001311 | K72.1 | — | — | — | — | 3 | 3 |
| Acute-on-chronic liver failure | D065290 | — | — | — | — | — | — | 3 | 3 |
| Loneliness | D008132 | — | R45.89 | — | — | — | — | 3 | 3 |
| Aging | D000375 | GO_0007568 | R41.81 | — | — | — | — | 3 | 3 |
| Drug interactions | D004347 | — | — | — | — | — | — | 2 | 2 |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | — | — | — | 2 | 2 |
| Depression | D003863 | — | F33.9 | — | — | — | — | 2 | 2 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | — | — | 2 | 2 |
Show 74 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Carvedilol |
| INN | carvedilol |
| Description | Carvedilol is a member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure. It has a role as a beta-adrenergic antagonist, an antihypertensive agent, an alpha-adrenergic antagonist, a vasodilator agent and a cardiovascular drug. It is a member of carbazoles, a secondary alcohol and a secondary amino compound. |
| Classification | Small molecule |
| Drug class | vasodilators (undefined group) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 |
Identifiers
| PDB | — |
| CAS-ID | 72956-09-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL723 |
| ChEBI ID | 3441 |
| PubChem CID | 2585 |
| DrugBank | DB01136 |
| UNII ID | 0K47UL67F2 (ChemIDplus, GSRS) |
Target
Agency Approved
Alternate
RYR2
RYR2
Organism
Homo sapiens
Gene name
RYR2
Gene synonyms
NCBI Gene ID
Protein name
ryanodine receptor 2
Protein synonyms
Cardiac muscle ryanodine receptor, Cardiac muscle ryanodine receptor-calcium release channel, cardiac-type ryanodine receptor, islet-type ryanodine receptor, kidney-type ryanodine receptor, ryanodine receptor 2 (cardiac), Type 2 ryanodine receptor
Uniprot ID
Mouse ortholog
Ryr2 (20191)
ryanodine receptor 2 (Q9ERN6)
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Carvedilol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 36,412 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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22,440 adverse events reported
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