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Drug ReportsCarbetocin
Carbetocin
Carbetocin is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target oxytocin receptor.
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Therapeutic Areas
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Trade Name
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Indications
FDA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H01: Pituitary and hypothalamic hormones and analogues
— H01B: Posterior pituitary lobe hormones
— H01BB: Oxytocin and analogues
— H01BB03: Carbetocin
HCPCS
No data
Clinical
Clinical Trials
93 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperphagiaD006963—R63.2——2——2
Prader-willi syndromeD011218Orphanet_739Q87.11——2——2
SyndromeD013577————2——2
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCarbetocin
INNcarbetocin
Description
Carbetocin is oxytocin in which the hydrogen on the phenolic hydroxy group is substituted by methyl, the amino group on the cysteine residue is substituted by hydrogen, and the sulfur of the cysteine residue is replaced by a methylene group. A synthetic carba-analogue of oxytocin, it is used to control bleeding after giving birth. Like oxytocin, it causes contraction of the uterus. It has a role as an oxytocic.
Classification
Protein
Drug classoxytocin derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
Identifiers
PDB—
CAS-ID37025-55-1
RxCUI—
ChEMBL IDCHEMBL3301668
ChEBI ID59204
PubChem CID16681432
DrugBankDB01282
UNII ID88TWF8015Y (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
OXTR
OXTR
Organism
Homo sapiens
Gene name
OXTR
Gene synonyms
NCBI Gene ID
5021
Protein name
oxytocin receptor
Protein synonyms
Uniprot ID
Q15071
Mouse ortholog
Oxtr (18430)
oxytocin receptor (P97926)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 783 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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115 adverse events reported
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