Captopril
Captopril (captopril) is a small molecule pharmaceutical. Captopril was first approved as Capoten on 1982-01-01. It is used to treat bartter syndrome, diabetic nephropathies, edema, heart failure, and left ventricular dysfunction amongst others in the USA. The pharmaceutical is active against angiotensin-converting enzyme.
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Commercial
Trade Name
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Captopril (discontinued: Capoten, Captopril)
CombinationsCaptopril hydrochlorothiazide (discontinued: Capozide, Captopril hydrochlorothiazide)
Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Captopril
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CAPOTEN | Strides Pharma Global | N-018343 DISCN | 1982-01-01 | 7 products, RLD |
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Captopril
+
Hydrochlorothiazide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CAPOZIDE 25/15 | Bristol Myers Squibb | N-018709 DISCN | 1984-10-12 | 1 products, RLD |
| CAPOZIDE 25/25 | Bristol Myers Squibb | N-018709 DISCN | 1984-10-12 | 1 products, RLD |
| CAPOZIDE 50/25 | Bristol Myers Squibb | N-018709 DISCN | 1984-10-12 | 1 products, RLD |
| CAPOZIDE 50/15 | Bristol Myers Squibb | N-018709 DISCN | 1984-10-12 | 1 products, RLD |
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| captopril | ANDA | 2024-10-15 |
| captopril and hydrochlorothiazide | ANDA | 2023-02-21 |
Indications
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Clinical Trials
90 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 6 | 1 | 2 | 8 | 7 | 23 |
| Hyperaldosteronism | D006929 | HP_0011736 | E26 | — | — | — | 1 | 10 | 11 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | — | 1 | 2 | 3 | 7 |
| Covid-19 | D000086382 | — | — | — | 2 | 2 | 1 | 1 | 6 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 1 | 2 | 1 | 3 | 6 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | 1 | — | 3 | 1 | 5 |
| Healthy volunteers/patients | — | — | — | 3 | — | — | 1 | — | 4 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | — | 1 | 1 | 3 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | 1 | 2 | 3 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | 1 | — | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | 1 | 3 | — | — | 3 |
| Essential hypertension | D000075222 | — | I10 | 1 | 1 | 1 | — | 1 | 3 |
| Neoplasms | D009369 | — | C80 | 2 | 2 | 1 | — | — | 3 |
| Pneumonia | D011014 | EFO_0003106 | — | — | 1 | 1 | — | — | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | 1 | — | 1 | 2 |
| Malaria | D008288 | EFO_0001068 | B54 | — | — | 1 | — | — | 1 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | — | — | 1 | — | — | 1 |
| Arterial occlusive diseases | D001157 | EFO_0009085 | — | — | — | 1 | — | — | 1 |
| Leukemia | D007938 | — | C95 | — | — | 1 | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | — | 1 | — | — | 1 |
Show 3 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood pressure | D001794 | EFO_0004325 | — | 1 | 1 | — | — | — | 2 |
| Fibrosis | D005355 | — | — | 1 | 2 | — | — | — | 2 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | — | — | 1 | 2 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 1 | — | — | — | 1 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | 1 | — | — | — | 1 |
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | 1 | — | — | — | 1 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 1 | 1 | — | — | — | 1 |
| Primary myelofibrosis | D055728 | — | D47.4 | 1 | 1 | — | — | — | 1 |
| Radiation injuries | D011832 | — | — | — | 1 | — | — | — | 1 |
Show 10 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pure autonomic failure | D054970 | — | — | 2 | — | — | — | — | 2 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | 1 | — | — | — | 1 | 2 |
| Shy-drager syndrome | D012791 | EFO_1001050 | — | 1 | — | — | — | — | 1 |
| Multiple system atrophy | D019578 | — | — | 1 | — | — | — | — | 1 |
| Takotsubo cardiomyopathy | D054549 | EFO_1002000 | I51.81 | 1 | — | — | — | — | 1 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | — | — | 1 |
| Pulmonary arterial hypertension | D000081029 | — | — | 1 | — | — | — | — | 1 |
| Muscular dystrophies | D009136 | HP_0003560 | G71.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 2 | 2 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | — | 2 | 2 |
| Mitral valve insufficiency | D008944 | HP_0001653 | — | — | — | — | — | 2 | 2 |
| Aneurysm | D000783 | HP_0002617 | I72.9 | — | — | — | — | 1 | 1 |
| Thoracic aortic aneurysm | D017545 | EFO_0004282 | — | — | — | — | — | 1 | 1 |
| Aortic aneurysm | D001014 | EFO_0001666 | I71.9 | — | — | — | — | 1 | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 1 | 1 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | — | 1 | 1 |
| Peri-implantitis | D057873 | EFO_1001390 | — | — | — | — | — | 1 | 1 |
| Heart murmurs | D006337 | HP_0030148 | R01.0 | — | — | — | — | 1 | 1 |
Show 19 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Captopril |
| INN | captopril |
| Description | Captopril is a L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and an antihypertensive agent. It is a pyrrolidinemonocarboxylic acid, a N-acylpyrrolidine, an alkanethiol and a L-proline derivative. |
| Classification | Small molecule |
| Drug class | aptamers, classical and mirror; antihypertensives (ACE inhibitors) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 62571-86-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1560 |
| ChEBI ID | 3380 |
| PubChem CID | 44093 |
| DrugBank | DB01197 |
| UNII ID | 9G64RSX1XD (ChemIDplus, GSRS) |
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Captopril
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Captopril
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Hydrochlorothiazide
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Safety
Black-box Warning
Black-box warning for: Captopril, Captopril and hydrochlorothiazide
Adverse Events
Top Adverse Reactions
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2,654 adverse events reported
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