Capreomycin
Capastat (capreomycin) is a protein pharmaceutical. Capreomycin was first approved as Capastat sulfate on 1982-01-01. It is used to treat mycobacterium infections and tuberculosis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Capreomycin sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CAPASTAT SULFATE | Epic Pharma | N-050095 DISCN | 1982-01-01 | 1 products, RLD |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| tuberculosis | EFO_0000774 | D014376 | A15-A19 |
| mycobacterium infections | — | D009164 | A31.9 |
Agency Specific
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Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | — | — | 1 | 4 | 5 |
| Multidrug-resistant tuberculosis | D018088 | EFO_0007381 | — | — | — | — | 1 | 1 | 2 |
Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | — | 2 | 2 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | — | — | 1 | 1 |
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | — | — | — | — | 1 | 1 |
| Aids-related opportunistic infections | D017088 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Capreomycin |
| INN | capreomycin |
| Description | Capreomycin is an antibiotic which is given in combination with other antibiotics for the treatment of tuberculosis. Specifically it is a second line treatment used for active drug resistant tuberculosis. It is given by injection into a vein or muscle.
|
| Classification | Protein |
| Drug class | antibiotics (Streptomyces strain) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H]1NC(=O)[C@@H](N)CNC(=O)[C@H](C2CCNC(=N)N2)NC(=O)/C(=C/NC(N)=O)NC(=O)[C@H](CNC(=O)CC(N)CCCN)NC1=O.N=C1NCCC([C@@H]2NC(=O)/C(=C/NC(N)=O)NC(=O)[C@H](CNC(=O)CC(N)CCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CNC2=O)N1 |
Identifiers
| PDB | — |
| CAS-ID | 11003-38-6 |
| RxCUI | 78903 |
| ChEMBL ID | CHEMBL2221250 |
| ChEBI ID | — |
| PubChem CID | 135483770 |
| DrugBank | DB00314 |
| UNII ID | 232HYX66HC (ChemIDplus, GSRS) |
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Safety
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476 adverse events reported
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