Camostat
Camostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against serine protease 1. In addition, it is known to target transmembrane protease serine 2.
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New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Clinical
Clinical Trials
29 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | — | 3 | 15 | 8 | 2 | — | 24 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 2 | 3 | 3 | — | — | 7 |
| Communicable diseases | D003141 | — | — | 2 | 2 | 2 | — | — | 5 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | 2 | 3 | 1 | — | — | 4 |
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | 1 | 1 | 1 | — | — | 3 |
| Coronavirus | D017934 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | — | — | 1 | — | — | — | 1 |
| Respiratory tract diseases | D012140 | — | — | — | 1 | — | — | — | 1 |
| Respiration disorders | D012120 | — | J00-J99 | — | 1 | — | — | — | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | 1 | — | — | — | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | — | — | — | 1 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 1 | — | — | — | 1 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 1 | — | — | — | 1 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | 1 | — | — | — | 1 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | 1 | 1 | — | — | — | 1 |
| Hemostatic disorders | D020141 | — | — | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Camostat |
| INN | camostat |
| Description | Camostat is a serine protease inhibitor. Serine protease enzymes have a variety of functions in the body, and so camostat has a diverse range of uses. Camostat is approved in Japan for the treatment of chronic pancreatitis and postoperative reflux esophagitis. The manufacturer is Ono Pharmaceutical. The drug is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease or pancreatitis.
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| Classification | Small molecule |
| Drug class | enzyme inhibitors: proteolytic enzyme inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)C(=O)COC(=O)Cc1ccc(OC(=O)c2ccc(NC(=N)N)cc2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 59721-28-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL590799 |
| ChEBI ID | — |
| PubChem CID | 2536 |
| DrugBank | DB13729 |
| UNII ID | 0FD207WKDU (ChemIDplus, GSRS) |
Target
Agency Approved
PRSS1
PRSS1
Organism
Homo sapiens
Gene name
PRSS1
Gene synonyms
TRP1, TRY1, TRYP1
NCBI Gene ID
Protein name
serine protease 1
Protein synonyms
Anionic trypsin I, Anionic trypsin-I, Beta-trypsin, Cationic trypsinogen, digestive zymogen, nonfunctional trypsin 1, Pretrypsinogen I, protease, serine 1, TCR V beta 4.1, Trypsin I, Trypsin-1, trypsinogen 1, trypsinogen A
Uniprot ID
Mouse ortholog
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Alternate
Variants
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Trends
PubMed Central
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Safety
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Adverse Events
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49 adverse events reported
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