Calcitriol
Calcitriol, Rocaltrol, Vectical (calcitriol) is a small molecule pharmaceutical. Calcitriol was first approved as Rocaltrol on 1982-01-01. It is used to treat hyperparathyroidism, hypocalcemia, psoriasis, rickets, and vitamin e deficiency in the USA. The pharmaceutical is active against vitamin D3 receptor.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Rocaltrol, Vectical (generic drugs available since 2001-10-12, discontinued: Calcijex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Calcitriol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VECTICAL | Galderma | N-022087 RX | 2009-01-23 | 1 products, RLD, RS |
| ROCALTROL | Validus Pharmaceuticals | N-018044 RX | 1982-01-01 | 2 products, RLD |
| ROCALTROL | Validus Pharmaceuticals | N-021068 RX | 1998-11-20 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| calcitriol | ANDA | 2023-12-25 |
| calcitrol | NDA authorized generic | 2023-05-15 |
| rocaltrol | New Drug Application | 2023-12-15 |
| vectical | New Drug Application | 2022-10-31 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
CALCITRIOL, VECTICAL, GALDERMA LABS LP | |||
| 2023-07-17 | NPP | ||
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11C: Vitamin a and d, incl. combinations of the two
— A11CC: Vitamin d and analogues
— A11CC04: Calcitriol
D: Dermatologicals
— D05: Antipsoriatics
— D05A: Antipsoriatics for topical use
— D05AX: Other antipsoriatics for topical use in atc
— D05AX03: Calcitriol
HCPCS
Code | Description |
|---|---|
| J0636 | Injection, calcitriol, 0.1 mcg |
Clinical
Clinical Trials
219 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriasis | D011565 | EFO_0000676 | L40 | 10 | 12 | 9 | 11 | 3 | 42 |
| Secondary hyperparathyroidism | D006962 | EFO_1001173 | — | — | 2 | 3 | 9 | 3 | 17 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | — | 3 | 10 | 3 | 17 |
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | 1 | 1 | 1 | 4 | 6 | 13 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 3 | 1 | 2 | 4 | 10 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | 2 | 2 | 3 | 1 | — | 7 |
| Neoplasms | D009369 | — | C80 | 6 | — | — | 1 | — | 7 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | 1 | 2 | 1 | 1 | 4 |
| Chronic kidney disease-mineral and bone disorder | D012080 | EFO_1001152 | N25.0 | — | 2 | — | 2 | — | 4 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | 1 | 1 | 1 | 3 |
Show 21 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 3 | 11 | 2 | — | 1 | 15 |
| Hypocalcemia | D006996 | HP_0002901 | E83.51 | — | 3 | 1 | — | 3 | 7 |
| Hyperparathyroidism | D006961 | EFO_0008506 | E21.3 | — | — | 1 | — | 2 | 3 |
| Adenomatous polyps | D018256 | — | D28 | — | — | 1 | — | — | 1 |
| Renal dialysis | D006435 | EFO_0010690 | Z99.2 | — | — | 1 | — | — | 1 |
| Angiofibroma | D018322 | EFO_1001761 | — | — | — | 1 | — | — | 1 |
| Heart transplantation | D016027 | EFO_0010673 | — | — | — | 1 | — | — | 1 |
| Osteopetrosis | D010022 | HP_0011002 | Q78.2 | — | — | 1 | — | — | 1 |
| Acne vulgaris | D000152 | EFO_0003894 | L70 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 2 | — | — | 1 | 4 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 1 | — | — | 1 | 3 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 3 | — | — | — | 3 |
| Hypoparathyroidism | D007011 | HP_0000829 | E20 | — | 1 | — | — | 2 | 3 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | — | 2 | — | — | — | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 2 | — | — | — | 2 |
| Crohn disease | D003424 | EFO_0000384 | K50 | 1 | 1 | — | — | 1 | 2 |
| Myelodysplastic syndromes | D009190 | — | D46 | — | 2 | — | — | — | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 2 | — | — | — | 2 |
| Adenocarcinoma | D000230 | — | — | 2 | 1 | — | — | — | 2 |
Show 28 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | — | — | — | 2 | 3 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Cocaine-related disorders | D019970 | — | F14 | 1 | — | — | — | — | 1 |
| Hypophosphatemic rickets | D063730 | — | E83.31 | 1 | — | — | — | — | 1 |
| Chronic disease | D002908 | — | — | 1 | — | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | — | — | — | 1 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | — | — | — | — | 1 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | 1 | — | — | — | — | 1 |
| Central nervous system neoplasms | D016543 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | — | — | — | 2 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 2 | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 1 | 1 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | — | — | — | — | 1 | 1 |
| Insulin resistance | D007333 | HP_0000855 | E88.819 | — | — | — | — | 1 | 1 |
| Allergic contact dermatitis | D017449 | — | L23 | — | — | — | — | 1 | 1 |
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | — | — | — | — | 1 | 1 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | — | 1 | 1 |
| Child development | D002657 | — | — | — | — | — | — | 1 | 1 |
| Aggressive periodontitis | D010520 | EFO_0006342 | K05.2 | — | — | — | — | 1 | 1 |
Show 8 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Calcitriol |
| INN | calcitriol |
| Description | Calcitriol is a hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol. It has a role as a bone density conservation agent, an antipsoriatic, an immunomodulator, an antineoplastic agent, a calcium channel modulator, a nutraceutical, a calcium channel agonist, a metabolite, a hormone, a human metabolite and a mouse metabolite. It is a hydroxycalciol, a member of D3 vitamins and a triol. |
| Classification | Small molecule |
| Drug class | vitamin D analogs |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O)C[C@@H](O)C[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 32222-06-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL846 |
| ChEBI ID | 17823 |
| PubChem CID | 5280453 |
| DrugBank | DB00136 |
| UNII ID | FXC9231JVH (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Calcitriol
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 21,271 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
2,126 adverse events reported
View more details
© 2020-2023 Collaborative Drug Discovery Inc. (CDD) | Terms of Use