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AboutPricing
Drug ReportsCalcitriol
Calcitriol
Calcitriol, Rocaltrol, Vectical (calcitriol) is a small molecule pharmaceutical. Calcitriol was first approved as Rocaltrol on 1982-01-01. It is used to treat hyperparathyroidism, hypocalcemia, psoriasis, rickets, and vitamin e deficiency in the USA. The pharmaceutical is active against vitamin D3 receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
skin and connective tissue diseasesD017437
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
Trade Name
FDA
EMA
Calcitriol, Rocaltrol, Vectical (discontinued: Calcijex, Calcitriol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Calcitriol
Tradename
Company
Number
Date
Products
VECTICALGaldermaN-022087 RX2009-01-23
1 products, RLD, RS
ROCALTROLValidus PharmaceuticalsN-018044 RX1982-01-01
2 products, RLD
ROCALTROLValidus PharmaceuticalsN-021068 RX1998-11-20
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
calcitriolANDA2025-02-10
calcitrolNDA authorized generic2023-05-15
rocaltrolNew Drug Application2023-12-15
vecticalNew Drug Application2024-10-24
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
psoriasisEFO_0000676D011565L40
hyperparathyroidismEFO_0008506D006961E21.3
hypocalcemiaHP_0002901D006996E83.51
ricketsEFO_0005583D012279E55.0
vitamin e deficiency—D014811E56.0
Agency Specific
FDA
EMA
Expiration
Code
CALCITRIOL, VECTICAL, GALDERMA LABS LP
2023-07-17NPP
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11C: Vitamin a and d, incl. combinations of the two
— A11CC: Vitamin d and analogues
— A11CC04: Calcitriol
D: Dermatologicals
— D05: Antipsoriatics
— D05A: Antipsoriatics for topical use
— D05AX: Other antipsoriatics for topical use in atc
— D05AX03: Calcitriol
HCPCS
Code
Description
J0636
Injection, calcitriol, 0.1 mcg
Clinical
Clinical Trials
222 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Crohn diseaseD003424EFO_0000384K5011———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCalcitriol
INNcalcitriol
Description
Calcitriol is a hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol. It has a role as a bone density conservation agent, an antipsoriatic, an immunomodulator, an antineoplastic agent, a calcium channel modulator, a nutraceutical, a calcium channel agonist, a metabolite, a hormone, a human metabolite and a mouse metabolite. It is a hydroxycalciol, a member of D3 vitamins and a triol.
Classification
Small molecule
Drug classvitamin D analogs
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
C=C1/C(=C\C=C2/CCC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCC(C)(C)O)C[C@@H](O)C[C@@H]1O
Identifiers
PDB—
CAS-ID32222-06-3
RxCUI—
ChEMBL IDCHEMBL846
ChEBI ID17823
PubChem CID5280453
DrugBankDB00136
UNII IDFXC9231JVH (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Calcitriol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 23,085 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,027 adverse events reported
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