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Drug ReportsCalcifediol
Calcifediol
Rayaldee (calcifediol) is a small molecule pharmaceutical. Calcifediol was first approved as Calderol on 1982-01-01.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Rayaldee (discontinued: Calderol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Calcifediol
Tradename
Company
Number
Date
Products
RAYALDEEEirgen PharmaN-208010 RX2016-06-17
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
rayaldeeNew Drug Application2024-01-19
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
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FDA Information
Calcifediol, Rayaldee, Eirgen
98616442034-03-14DP
103000782034-03-14DP
103575022034-03-14DP
112535282034-03-14DP
84263912028-08-27U-1872
83614882028-07-19DP
82071492028-04-25U-1871
87783732028-04-25U-1873
94088582028-04-25U-1888
94984862028-04-25U-1920
99251472028-04-25DPU-2255, U-2256, U-2257, U-2258, U-2259
111545092028-04-25U-3248
89064102027-02-02DP
99435302027-02-02U-2274
102134422027-02-02DP
ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11C: Vitamin a and d, incl. combinations of the two
— A11CC: Vitamin d and analogues
— A11CC06: Calcifediol
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H05: Calcium homeostasis
— H05B: Anti-parathyroid agents
— H05BX: Other anti-parathyroid agents in atc
— H05BX05: Calcifediol
HCPCS
No data
Clinical
Clinical Trials
164 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OsteoporosisD010024EFO_0003882M81.0——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCalcifediol
INNcalcifediol
Description
Calcidiol is a hydroxycalciol that is calciol in which the hydrogen at position 25 has been replaced by a hydroxy group. A prehormone resulting from the oxidation of calciol in the liver, it is further hydroxylated in the kidney to give calcitriol, the active form of vitamin D3. It has a role as a bone density conservation agent, a nutraceutical, a metabolite, a human metabolite and a mouse metabolite. It is a hydroxycalciol, a member of D3 vitamins and a diol.
Classification
Small molecule
Drug classvitamin D analogs
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@@]2(C)[C@H]1CC[C@@H]2[C@H](C)CCCC(C)(C)O.O
Identifiers
PDB—
CAS-ID19356-17-3
RxCUI1855064
ChEMBL IDCHEMBL3544909
ChEBI ID—
PubChem CID5283731
DrugBankDB00146
UNII IDT0WXW8F54E (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Rayaldee – Opko Health
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Estimated US medical usage
Calcifediol
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,089 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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761 adverse events reported
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