Caficrestat
Caficrestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical
Clinical Trials
163 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 21 | 3 | 1 | 1 | 2 | 25 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 2 | — | — | 2 | 1 | 5 |
| Hepatitis | D006505 | — | K75.9 | 3 | — | 1 | 1 | — | 5 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | 1 | 2 | 3 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | 1 | — | 1 | 1 | — | 3 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | 1 | — | 2 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | — | B19.2 | 11 | 1 | 1 | — | — | 12 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 4 | 2 | 1 | — | — | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | 1 | — | 2 | 4 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | 2 | — | 2 | 4 |
| Crohn disease | D003424 | EFO_0000384 | K50 | — | — | 2 | — | 1 | 3 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | 1 | 1 | — | — | 3 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 1 | — | 1 | — | 1 | 3 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | — | 1 | — | 2 | 3 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | 2 | — | — | 3 |
| Clostridium infections | D003015 | EFO_1000874 | A05.2 | — | — | 2 | — | — | 2 |
Show 36 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | 1 | — | — | — | 7 |
| Melanoma | D008545 | — | — | 4 | 1 | — | — | — | 4 |
| Leukemia | D007938 | — | C95 | 4 | 1 | — | — | — | 4 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 2 | — | — | 1 | 4 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | — | — | 2 | 3 |
| Head and neck neoplasms | D006258 | — | — | 2 | 1 | — | — | — | 3 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 2 | 1 | — | — | — | 3 |
| Carcinoma | D002277 | — | C80.0 | 1 | 2 | — | — | — | 3 |
| Lymphoma | D008223 | — | C85.9 | 3 | 1 | — | — | — | 3 |
| Myeloid leukemia | D007951 | — | C92 | 3 | 1 | — | — | — | 3 |
Show 76 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepacivirus | D016174 | — | — | 7 | — | — | — | — | 7 |
| Lung neoplasms | D008175 | — | C34.90 | 2 | — | — | — | 2 | 4 |
| Hiv | D006678 | — | O98.7 | 4 | — | — | — | — | 4 |
| Colorectal neoplasms | D015179 | — | — | 2 | — | — | — | 1 | 3 |
| Hypertension | D006973 | EFO_0000537 | I10 | 2 | — | — | — | 1 | 3 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | — | — | — | 1 | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | — | — | — | — | 2 |
| Oxidative stress | D018384 | EFO_1001905 | — | 1 | — | — | — | 1 | 2 |
| Urologic neoplasms | D014571 | — | C64-C68 | 1 | — | — | — | — | 1 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
Show 20 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lentigo | D007911 | — | L81.4 | — | — | — | — | 2 | 2 |
| Multiple myeloma | D009101 | — | C90.0 | — | — | — | — | 1 | 1 |
| Sarcoma | D012509 | — | — | — | — | — | — | 1 | 1 |
| Cataract | D002386 | EFO_0001059 | H26.9 | — | — | — | — | 1 | 1 |
| Sars-cov-2 | D000086402 | — | — | — | — | — | — | 1 | 1 |
| Vascular dementia | D015140 | — | F01 | — | — | — | — | 1 | 1 |
| Beta-thalassemia | D017086 | Orphanet_848 | D56.1 | — | — | — | — | 1 | 1 |
| Thalassemia | D013789 | EFO_1001996 | D56 | — | — | — | — | 1 | 1 |
| Dental caries | D003731 | EFO_0003819 | K02 | — | — | — | — | 1 | 1 |
| Male circumcision | D002944 | EFO_0003953 | — | — | — | — | — | 1 | 1 |
Show 23 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Caficrestat |
| INN | caficrestat |
| Description | Caficrestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: aldose-reductase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)Cc1nn(Cc2nc3cc(C(F)(F)F)ccc3s2)c(=O)c2nccnc12 |
Identifiers
| PDB | — |
| CAS-ID | 1355612-71-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297455 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | E8I3O45DDU (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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