Doxorubicin hydrochloride
Doxil, Doxorubicin, Myocet, Pegylated (doxorubicin hydrochloride) is a small molecule pharmaceutical. Doxorubicin hydrochloride was first approved as Doxorubicin hydrochloride on 1982-01-01. It is used to treat breast neoplasms, gastrointestinal neoplasms, hodgkin disease, liver neoplasms, and lung neoplasms amongst others in the USA. It has been approved in Europe to treat breast neoplasms, kaposi sarcoma, multiple myeloma, and ovarian neoplasms. It is known to target DNA topoisomerase 2-alpha.
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| adriamycin | ANDA | 2024-04-11 |
| doxil | New Drug Application | 2023-08-31 |
| doxorubicin hydrochloride | ANDA | 2024-12-11 |
| doxorubicin hydrochloride liposome | NDA authorized generic | 2022-05-31 |
| doxorubicin hydrochloride, liposomal | unapproved drug for use in drug shortage | 2023-12-19 |
Indications
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Agency Specific
FDA
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Clinical
Clinical Trials
2606 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | — | 2 | 1 | — | — | 3 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | 3 | — | — | 3 |
| Neutropenia | D009503 | — | D70 | — | 1 | 2 | — | — | 2 |
| Chemotherapy-induced febrile neutropenia | D064146 | — | — | — | 1 | 2 | — | — | 2 |
| Mucinous adenocarcinoma | D002288 | — | — | — | — | 1 | — | — | 1 |
| Ductal carcinoma breast | D018270 | — | — | — | — | 1 | — | — | 1 |
| Inflammatory breast neoplasms | D058922 | — | — | — | — | 1 | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | — | 1 | — | — | 1 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell lymphoma | D016393 | — | — | — | 1 | — | — | — | 1 |
| Hodgkin disease | D006689 | — | C81 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Doxorubicin hydrochloride |
| INN | doxorubicin |
| Description | Doxorubicin is a deoxy hexoside, an anthracycline, an anthracycline antibiotic, an aminoglycoside, a member of tetracenequinones, a member of p-quinones, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It has a role as an Escherichia coli metabolite. It is a conjugate base of a doxorubicin(1+). It derives from a hydride of a tetracene. |
| Classification | Small molecule |
| Drug class | antineoplastic antibiotics (daunorubicin type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1.Cl |
Identifiers
| PDB | — |
| CAS-ID | 25316-40-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL359744 |
| ChEBI ID | — |
| PubChem CID | 31703 |
| DrugBank | DB00997 |
| UNII ID | 80168379AG (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
TOP2A
TOP2A
Organism
Homo sapiens
Gene name
TOP2A
Gene synonyms
TOP2
NCBI Gene ID
Protein name
DNA topoisomerase 2-alpha
Protein synonyms
DNA gyrase, DNA topoisomerase (ATP-hydrolyzing), DNA topoisomerase II, 170 kD, DNA topoisomerase II, alpha isozyme, topoisomerase (DNA) II alpha 170kDa
Uniprot ID
Mouse ortholog
Top2a (21973)
DNA topoisomerase 2-alpha (Q01320)
Variants
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Safety
Black-box Warning
Black-box warning for: Adriamycin, Doxil, Doxorubicin hydrochloride, Doxorubicin hydrochloride liposome
Adverse Events
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105,104 adverse events reported
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