COTADUTIDE
Cotadutide is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
24 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 5 | 10 | — | — | — | 14 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 4 | 10 | — | — | — | 13 |
| Overweight | D050177 | — | E66.3 | 2 | 7 | — | — | — | 8 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 2 | 2 | — | — | — | 4 |
| Fatty liver | D005234 | EFO_0003934 | — | 2 | 2 | — | — | — | 4 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | 1 | — | — | — | 2 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | — | — | — | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 1 | — | — | — | 2 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | 1 | — | — | — | 2 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 1 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
| Alcoholic fatty liver | D005235 | — | K70.0 | 2 | — | — | — | — | 2 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | COTADUTIDE |
| INN | cotadutide |
| Description | Cotadutide is an experimental drug for the treatment of type 2 diabetes mellitus. It lowers blood glucose levels by mimicking the human hormones glucagon-like peptide 1 and glucagon, which play a role in blood sugar regulation. The drug is a peptide that is injected under the skin.
|
| Classification | Protein |
| Drug class | peptides: oxyntomodulin analogs |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)O)C(C)C)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 1686108-82-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297630 |
| ChEBI ID | — |
| PubChem CID | 134694273 |
| DrugBank | DB15194 |
| UNII ID | QL6A9B13HW (ChemIDplus, GSRS) |
Target
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Trends
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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