CIPARGAMIN
Cipargamin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target P-type sodium-transporting ATPase4.
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Commercial
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Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malaria | D008288 | EFO_0001068 | B54 | 3 | 6 | — | — | — | 9 |
| Falciparum malaria | D016778 | EFO_0007444 | B50 | 2 | 1 | — | — | — | 3 |
| Vivax malaria | D016780 | EFO_0007445 | B51 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CIPARGAMIN |
| INN | cipargamin |
| Description | Cipargamin (NITD609, KAE609) is an experimental synthetic antimalarial drug belonging to the spiroindolone class. The compound was developed at the Novartis Institute for Tropical Diseases in Singapore, through a collaboration with the Genomics Institute of the Novartis Research Foundation (GNF), the Biomedical Primate Research Centre and the Swiss Tropical Institute.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H]1Cc2c([nH]c3cc(Cl)c(F)cc23)[C@@]2(N1)C(=O)Nc1ccc(Cl)cc12 |
Identifiers
| PDB | — |
| CAS-ID | 1193314-23-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1082723 |
| ChEBI ID | — |
| PubChem CID | 44469321 |
| DrugBank | DB12306 |
| UNII ID | Z7Q4FWA04P (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ATP4
ATP4
Organism
Plasmodium falciparum (isolate 3D7)
Gene name
ATP4
Gene synonyms
NCBI Gene ID
—
Protein name
P-type sodium-transporting ATPase4
Protein synonyms
P-type cation-transporter ATPase4
Uniprot ID
Mouse ortholog
—
—
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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