CELGOSIVIR
Celgosivir is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | — | B19.2 | — | 4 | — | — | — | 4 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | 4 | — | — | — | 4 |
| Hepatitis | D006505 | — | K75.9 | — | 4 | — | — | — | 4 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | 4 | — | — | — | 4 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 2 | — | — | — | 3 |
| Fever | D005334 | — | R50.9 | 2 | 2 | — | — | — | 2 |
| Dengue | D003715 | — | A90 | 2 | 2 | — | — | — | 2 |
| Chronic hepatitis | D006521 | — | K73.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CELGOSIVIR |
| INN | celgosivir |
| Description | Celgosivir, in development by Migenix for the treatment of hepatitis C virus (HCV) infection, is an oral prodrug of the natural product castanospermine that inhibits alpha-glucosidase I, an enzyme that plays a critical role in viral maturation by initiating the processing of the N-linked oligosaccharides of viral envelope glycoproteins. Celgosivir is well absorbed in vitro and in vivo, and is rapidly converted to castanospermine. Celgosivir has a novel mechanism of action (preventing the glycosylation of viral proteins by the host), and demonstrates broad antiviral activity in vitro.
|
| Classification | Small molecule |
| Drug class | antivirals: glucosidase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCC(=O)O[C@H]1CN2CC[C@H](O)[C@@H]2[C@@H](O)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 121104-96-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2110737 |
| ChEBI ID | — |
| PubChem CID | 60734 |
| DrugBank | — |
| UNII ID | 895VG117HN (ChemIDplus, GSRS) |
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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