CAPRAVIRINE
Capravirine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 6 | — | — | — | 9 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 2 | 1 | — | — | — | 3 |
| Hiv | D006678 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 2 | — | — | — | — | 2 |
| Communicable diseases | D003141 | — | — | 2 | — | — | — | — | 2 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CAPRAVIRINE |
| INN | capravirine |
| Description | Capravirine was a non-nucleoside reverse transcriptase inhibitor which reached phase II trials before development was discontinued by Pfizer. Both phase IIb trials which were conducted failed to demonstrate that therapy with capravirine provided any significant advantage over existing triple-drug HIV therapies, and pharmacology studies showed that capravirine may interact with other HIV drugs.
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| Classification | Small molecule |
| Drug class | antivirals: non-nucleoside reverse transcriptase inhibitors, not benzoxazinone derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)c1nc(COC(N)=O)n(Cc2ccncc2)c1Sc1cc(Cl)cc(Cl)c1 |
Identifiers
| PDB | — |
| CAS-ID | 178979-85-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL435128 |
| ChEBI ID | — |
| PubChem CID | 1783 |
| DrugBank | — |
| UNII ID | VHC779598X (ChemIDplus, GSRS) |
Target
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Additional graphs summarizing 85 documents
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Safety
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Adverse Events
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19 adverse events reported
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