Butabarbital
Butabarb, Butalan, Buticaps, Butisol, Sarisol (butabarbital) is a small molecule pharmaceutical. Butabarbital was first approved as Butisol sodium on 1982-01-01. It is used to treat sleep initiation and maintenance disorders in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| sleep initiation and maintenance disorders | — | D007319 | F51.01 |
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
31 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anesthesia | D000758 | — | — | — | — | — | 1 | — | 1 |
| Intracranial vasospasm | D020301 | EFO_1000994 | G45.9 | — | — | — | 1 | — | 1 |
| Dysmenorrhea | D004412 | HP_0100607 | N94.6 | — | — | — | 1 | — | 1 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | — | — | — | 1 | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | 1 | — | 1 |
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | — | — | — | — | 1 | — | 1 |
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | — | — | — | 1 | — | 1 |
| Myocarditis | D009205 | — | I51.4 | — | — | — | 1 | — | 1 |
| Renal dialysis | D006435 | EFO_0010690 | Z99.2 | — | — | — | 1 | — | 1 |
| Virus diseases | D014777 | — | B34 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | — | 1 | — | — | 1 |
| Traumatic stress disorders | D040921 | — | — | — | — | 1 | — | — | 1 |
| Gastroenteritis | D005759 | EFO_1001463 | K52.9 | — | — | 1 | — | — | 1 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | 1 | 1 | — | — | 1 |
| Glaucoma | D005901 | EFO_0000516 | H40 | — | 1 | 1 | — | — | 1 |
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | 1 | 1 | — | — | 1 |
| Regional blood flow | D012039 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | 1 | 1 | — | — | 3 | 5 |
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | 1 | 2 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | 1 | — | — | 1 | 2 |
| Muscle cramp | D009120 | HP_0003394 | — | — | 1 | — | — | — | 1 |
| Spasm | D013035 | — | M62.83 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | — | — | — | — | 2 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | — | — | — | 1 | 2 |
| Vasculogenic impotence | D018783 | EFO_1001234 | — | 1 | — | — | — | — | 1 |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | 1 | — | — | — | — | 1 |
| Hyperplasia | D006965 | EFO_0000536 | — | 1 | — | — | — | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | — | — | — | — | 1 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | 1 | — | — | — | — | 1 |
| Cognition disorders | D003072 | — | — | 1 | — | — | — | — | 1 |
| Neurocognitive disorders | D019965 | — | F09 | 1 | — | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Penile neoplasms | D010412 | — | C60 | — | — | — | — | 1 | 1 |
| Oligospermia | D009845 | — | N46.1 | — | — | — | — | 1 | 1 |
| Male infertility | D007248 | EFO_0004248 | N46 | — | — | — | — | 1 | 1 |
| Infertility | D007246 | HP_0000789 | — | — | — | — | — | 1 | 1 |
| Covid-19 | D000086382 | — | — | — | — | — | — | 1 | 1 |
| Acute pain | D059787 | — | R52 | — | — | — | — | 1 | 1 |
| Labor pain | D048949 | — | — | — | — | — | — | 1 | 1 |
| Induced labor | D007751 | — | — | — | — | — | — | 1 | 1 |
| Contraception | D003267 | — | — | — | — | — | — | 1 | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Butabarbital |
| INN | secbutabarbital |
| Description | Butabarbital is a member of barbiturates. |
| Classification | Small molecule |
| Drug class | barbituric acid derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCC(C)C1(CC)C(=O)NC(=O)NC1=O |
Identifiers
| PDB | — |
| CAS-ID | 125-40-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL449 |
| ChEBI ID | 3228 |
| PubChem CID | 2479 |
| DrugBank | DB00237 |
| UNII ID | P0078O25A9 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Butabarbital
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
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Additional graphs summarizing 162 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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42 adverse events reported
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