Bumetanide
Bumetanide, Bumex (bumetanide) is a small molecule pharmaceutical. Bumetanide was first approved as Bumex on 1983-02-28. It is used to treat ascites, chronic kidney failure, edema, heart failure, and hypertension amongst others in the USA. The pharmaceutical is active against solute carrier family 12 member 1. In addition, it is known to target G-protein coupled receptor 35 and solute carrier family 12 member 2.
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Commercial
Trade Name
FDA
EMA
Bumetanide, Bumex (discontinued: Bumetanide, Bumex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bumetanide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BUMEX | Validus Pharmaceuticals | N-018225 RX | 1983-02-28 | 3 products, RLD |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bumetanide | ANDA | 2024-10-21 |
| bumex | New Drug Application | 2023-12-12 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C03: Diuretics
— C03C: High-ceiling diuretics
— C03CA: Sulfonamides, high-ceiling diuretics, plain
— C03CA02: Bumetanide
— C03CB: Sulfonamides and potassium in combination, high-ceiling diruetics, excluding thiazides
— C03CB02: Bumetanide and potassium
— C03E: Diuretics and potassium-sparing agents in combination
— C03EB: High-ceiling diuretics and potassium-sparing agents
— C03EB02: Bumetanide and potassium-sparing agents
HCPCS
Code | Description |
|---|---|
| S0171 | Injection, bumetanide, 0.5 mg |
Clinical
Clinical Trials
43 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | HP_0001635 | I50 | 4 | 2 | 4 | 7 | 4 | 20 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 1 | — | 2 | 1 | 4 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | 1 | 2 | 3 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 1 | — | 2 | — | 3 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | 1 | — | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | 1 | — | 1 |
| Edema | D004487 | HP_0000969 | R60.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Autistic disorder | D001321 | HP_0000717 | F84.0 | — | 2 | 3 | — | — | 5 |
| Autism spectrum disorder | D000067877 | HP_0000729 | F84.0 | — | 1 | 2 | — | — | 3 |
| Pervasive child development disorders | D002659 | EFO_0003756 | F84 | — | 1 | 1 | — | — | 2 |
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | — | 1 | 1 | — | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | 1 | — | — | 1 | 2 |
| Seizures | D012640 | HP_0002069 | G40.4 | 2 | 1 | — | — | — | 2 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 1 | — | — | — | 2 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | 1 | 1 | — | — | — | 1 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | 1 | — | — | — | 1 |
| Paralysis | D010243 | HP_0003470 | — | — | 1 | — | — | — | 1 |
| Hypokalemic periodic paralysis | D020514 | — | G72.3 | — | 1 | — | — | — | 1 |
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | — | — | — | — | 1 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | 1 | — | — | — | — | 1 |
| Drug resistant epilepsy | D000069279 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | — | — | — | — | — | 1 | 1 |
| Critical illness | D016638 | — | — | — | — | — | — | 1 | 1 |
| Critical care | D003422 | — | — | — | — | — | — | 1 | 1 |
| Fluid shifts | D018495 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bumetanide |
| INN | bumetanide |
| Description | Bumetanide is a member of the class of benzoic acids that is 4-phenoxybenzoic acid in which the hydrogens ortho to the phenoxy group are substituted by butylamino and sulfamoyl groups. Bumetanide is a diuretic, and is used for treatment of oedema associated with congestive heart failure, hepatic and renal disease. It has a role as a diuretic and an EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor. It is a sulfonamide, an amino acid and a member of benzoic acids. |
| Classification | Small molecule |
| Drug class | diuretics (piretanide type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCNc1cc(C(=O)O)cc(S(N)(=O)=O)c1Oc1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 28395-03-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1072 |
| ChEBI ID | 3213 |
| PubChem CID | 2471 |
| DrugBank | DB00887 |
| UNII ID | 0Y2S3XUQ5H (ChemIDplus, GSRS) |
Target
Agency Approved
SLC12A1
SLC12A1
Organism
Homo sapiens
Gene name
SLC12A1
Gene synonyms
NKCC2
NCBI Gene ID
Protein name
solute carrier family 12 member 1
Protein synonyms
bumetanide-sensitive cotransporter type 1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter, Na-K-2Cl cotransporter, Na-K-2Cl cotransporter 2, solute carrier family 12 (sodium/potassium/chloride transporter), member 1, solute carrier family 12 (sodium/potassium/chloride transporters), member 1
Uniprot ID
Mouse ortholog
Slc12a1 (20495)
solute carrier family 12 member 1 (Q9Z1E0)
Alternate
SLC12A2
SLC12A2
Organism
Homo sapiens
Gene name
SLC12A2
Gene synonyms
NKCC1
NCBI Gene ID
Protein name
solute carrier family 12 member 2
Protein synonyms
Basolateral Na-K-Cl symporter, bumetanide-sensitive cotransporter type 2, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, protein phosphatase 1, regulatory subunit 141, solute carrier family 12 (sodium/potassium/chloride transporter), member 2, solute carrier family 12 (sodium/potassium/chloride transporters), member 2
Uniprot ID
Mouse ortholog
Slc12a2 (20496)
solute carrier family 12 member 2 (P55012)
Variants
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Financial
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Estimated US medical usage
Bumetanide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Bumetanide, Bumex
Adverse Events
Top Adverse Reactions
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2,707 adverse events reported
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