Bulevirtide
Hepcludex (bulevirtide) is a protein pharmaceutical. Bulevirtide was first approved as Hepcludex on 2020-07-31. It has been approved in Europe to treat chronic hepatitis d.
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Brand Name | Status | Last Update |
|---|---|---|
| hepcludex | Biologic Licensing Application | 2026-05-22 |
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Clinical
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28 clinical trials
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic hepatitis | D006521 | — | K73.9 | 1 | 1 | 1 | — | 1 | 4 |
| Chronic hepatitis d | D019701 | — | — | — | 1 | 1 | — | — | 2 |
| Hepatitis d | D003699 | EFO_0007304 | — | — | 1 | 1 | — | — | 2 |
| Hepatitis | D006505 | — | K75.9 | — | 1 | 1 | — | — | 2 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | 1 | 1 | — | — | 2 |
Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bulevirtide |
| INN | bulevirtide |
| Description | Bulevirtide, sold under the brand name Hepcludex, is an antiviral medication for the treatment of chronic hepatitis D (in the presence of hepatitis B).
|
| Classification | Protein |
| Drug class | peptides: antiviral peptides; antivirals |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >8RQF:H|Heavy chain of Fab3
EISEVQLVESGGGLVQPGGSLRLSCAASGFNVSSSYIHWVRQAPGKGLEWVASISPYYSYTSYADSVKGRFTISADTSKN
TAYLQMNSLRAEDTAVYYCARYQYDYYYSYYAGLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYF
PEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT
>8RQF:L|Light chain of Fab3
SDIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQ
PEDFATYYCQQYRYSLITFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS
QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Identifiers
| PDB | 8RQF |
| CAS-ID | 2012558-47-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297711 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB15248 |
| UNII ID | WKM56H3TLB (ChemIDplus, GSRS) |
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Safety
Black-box Warning
Black-box warning for: Hepcludex
Adverse Events
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72 adverse events reported
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