Budiodarone
Budiodarone is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 3 | 1 | — | — | 3 |
| Atrial flutter | D001282 | EFO_0003911 | — | — | 2 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ventricular tachycardia | D017180 | — | I47.2 | — | 2 | — | — | — | 2 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | 2 | — | — | — | 2 |
| Tachycardia | D013610 | — | R00.0 | — | 1 | — | — | — | 1 |
| Ventricular fibrillation | D014693 | EFO_0004287 | I49.01 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Budiodarone |
| INN | budiodarone |
| Description | Budiodarone (ATI-2042) is an antiarrhythmic agent and chemical analog of amiodarone that is currently being studied in clinical trials. Amiodarone is considered the most effective antiarrhythmic drug available, but its adverse side effects, including hepatic, pulmonary and thyroid toxicity as well as multiple drug interactions, are discouraging its use. Budiodarone only differs in structure from amiodarone through the presence of a sec-butyl acetate side chain at position 2 of the benzofuran moiety. This side chain allows for budiodarone to have a shorter half-life in the body than amiodarone (7 hours versus 35–68 days) which allows it to have a faster onset of action and metabolism while still maintaining similar electrophysiological activity. The faster metabolism of budiodarone allows for fewer adverse side effects than amiodarone principally due to decreased levels of toxicity in the body.
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| Classification | Small molecule |
| Drug class | antiarrhythmics: indicates high iodine content |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@H](C)OC(=O)Cc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1 |
Identifiers
| PDB | — |
| CAS-ID | 335148-45-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2105631 |
| ChEBI ID | — |
| PubChem CID | 9833332 |
| DrugBank | — |
| UNII ID | F5Y53150C8 (ChemIDplus, GSRS) |
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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