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Drug ReportsBromocriptine
Bromocriptine
Bromocriptine, Cycloset, Parlodel (bromocriptine) is a small molecule pharmaceutical. Bromocriptine was first approved as Parlodel on 1982-01-01. It is used to treat acromegaly, adenoma, amenorrhea, galactorrhea, and hyperprolactinemia amongst others in the USA. The pharmaceutical is active against D(3) dopamine receptor, D(4) dopamine receptor, and D(2) dopamine receptor. In addition, it is known to target 5-hydroxytryptamine receptor 2B, alpha-2B adrenergic receptor, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1D, D(1A) dopamine receptor, D(1B) dopamine receptor, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 7, alpha-2A adrenergic receptor, and alpha-2C adrenergic receptor.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
musculoskeletal diseasesD009140
nervous system diseasesD009422
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
Trade Name
FDA
EMA
Bromocriptine, Cycloset, Parlodel (discontinued: Bromocriptine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bromocriptine mesylate
Tradename
Company
Number
Date
Products
PARLODELValidus PharmaceuticalsN-017962 RX1982-01-01
2 products, RLD
CYCLOSETVeroScienceN-020866 RX2009-05-05
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
bromocriptine mesylateANDA2024-11-25
cyclosetNew Drug Application2024-10-24
parlodelNew Drug Application2023-12-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
parkinson diseaseEFO_0002508D010300G20
amenorrhea—D000568N91.2
infertilityHP_0000789D007246—
adenoma—D000236—
hypogonadismHP_0000044D007006E23.0
hyperprolactinemiaHP_0000870D006966E22.1
acromegaly—D000172—
neuroleptic malignant syndromeEFO_1001379D009459G21.0
galactorrhea—D005687—
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Bromocriptine Mesylate, Cycloset, Veroscience
84311552032-04-30DPU-976
86139472032-04-30DPU-976
91925762032-04-30DPU-976
95221172032-04-30DPU-976, U-1939
97005552032-04-30DPU-2183, U-2184, U-2185, U-2186, U-2187, U-2188, U-2189, U-2190, U-2191, U-2192, U-2193, U-2194, U-2195, U-2196, U-2197, U-2198
99934742032-04-30U-2384, U-2385, U-2386, U-2387, U-2388, U-2389, U-2390, U-2391, U-2392, U-2393
106880942032-04-30U-2870, U-2871, U-2872, U-2873, U-2874, U-2875, U-2876, U-2877, U-2878, U-2879, U-2880, U-2881, U-2882, U-2883, U-2884, U-2885, U-2886, U-2887, U-2888
110005222032-04-30U-3119, U-3120, U-3121, U-3122
88777082030-06-07DPU-1706
93520252030-06-07U-2111, U-2112, U-2113, U-2114, U-2115, U-2116, U-2117, U-2118, U-2119
98954222030-06-07U-2114, U-2116, U-2281, U-2282, U-2283, U-2284, U-2285, U-2286, U-2287
106881552030-06-07U-2281, U-2890, U-2891, U-2892, U-2893, U-2894, U-2895, U-2896, U-2897, U-2898, U-2899, U-2900, U-2901, U-2902, U-2903, U-2904, U-2905, U-2906, U-2907, U-2908, U-2909, U-2910, U-2911, U-2912, U-2913, U-2914, U-2915, U-2916, U-2917, U-2918, U-2919, U-2920, U-2921, U-2922, U-2923, U-2924, U-2925, U-2926, U-2927, U-2928, U-2929, U-2930, U-2931, U-2932, U-2933, U-2934, U-2935, U-2936, U-2937
78883102023-07-25U-1433
81379922023-07-25U-1433
81379932023-07-25U-1433
81379942023-07-25U-1433
ATC Codes
G: Genito urinary system and sex hormones
— G02: Other gynecologicals in atc
— G02C: Other gynecologicals in atc
— G02CB: Prolactine inhibitors
— G02CB01: Bromocriptine
N: Nervous system drugs
— N04: Anti-parkinson drugs
— N04B: Dopaminergic agents
— N04BC: Dopamine agonists
— N04BC01: Bromocriptine
HCPCS
No data
Clinical
Clinical Trials
50 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———2————2
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBromocriptine
INNbromocriptine
Description
Bromocriptine is an indole alkaloid. It has a role as an antiparkinson drug, a hormone antagonist, a dopamine agonist and an antidyskinesia agent. It derives from a hydride of an ergotaman.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]c(Br)c(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12
Identifiers
PDB—
CAS-ID25614-03-3
RxCUI—
ChEMBL IDCHEMBL493
ChEBI ID3181
PubChem CID31101
DrugBankDB01200
UNII ID3A64E3G5ZO (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CYP3A4
CYP3A4
Organism
Homo sapiens
Gene name
CYP3A4
Gene synonyms
CYP3A3
NCBI Gene ID
1576
Protein name
cytochrome P450 3A4
Protein synonyms
1,4-cineole 2-exo-monooxygenase, 1,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase (sulfoxide-forming), Albendazole sulfoxidase, Cholesterol 25-hydroxylase, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 HLp, Cytochrome P450 NF-25, cytochrome P450, family 3, subfamily A, polypeptide 4, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, Cytochrome P450-PCN1, glucocorticoid-inducible P450, Nifedipine oxidase, P450-III, steroid inducible, Quinine 3-monooxygenase, taurochenodeoxycholate 6-alpha-hydroxylase
Uniprot ID
P08684
Mouse ortholog
—
—
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Bromocriptine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 9,021 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,863 adverse events reported
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