Bromhexine
Bromhexine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | — | 1 | — | 2 | 3 | — | 6 |
| Pneumonia | D011014 | EFO_0003106 | — | 1 | — | — | 1 | 1 | 3 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | 1 | — | 1 |
| Communicable diseases | D003141 | — | — | — | — | — | 1 | — | 1 |
| Bronchiolitis | D001988 | HP_0011950 | — | — | — | — | 1 | — | 1 |
| Treatment outcome | D016896 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | — | 1 | — | 1 | 2 |
| Respiratory tract diseases | D012140 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Viral pneumonia | D011024 | EFO_0007541 | J12.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sars-cov-2 | D000086402 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bromhexine |
| INN | bromhexine |
| Description | Bromhexine is a substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum). It has a role as a mucolytic. It is a substituted aniline, a tertiary amino compound and an organobromine compound. It is a conjugate base of a bromhexine(1+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(Cc1cc(Br)cc(Br)c1N)C1CCCCC1 |
Identifiers
| PDB | — |
| CAS-ID | 3572-43-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL253376 |
| ChEBI ID | 77032 |
| PubChem CID | 2442 |
| DrugBank | DB09019 |
| UNII ID | Q1J152VB1P (ChemIDplus, GSRS) |
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Safety
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411 adverse events reported
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