Azopt(brinzolamide)
Azarga, Azopt, Brinzolamide, Simbrinza (brinzolamide) is a small molecule pharmaceutical. Brinzolamide was first approved as Azopt on 1998-04-01. It is used to treat open-angle glaucoma in the USA. It has been approved in Europe to treat ocular hypertension and open-angle glaucoma. The pharmaceutical is active against carbonic anhydrase 7. In addition, it is known to target carbonic anhydrase 12, carbonic anhydrase 14, and carbonic anhydrase 1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| eye diseases | D005128 |
Trade Name
FDA
EMA
Azopt, Brinzolamide
CombinationsSimbrinza
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Brimonidine tartrate
+
Brinzolamide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SIMBRINZA | Alcon Research | N-204251 RX | 2013-04-19 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| azopt | New Drug Application | 2023-11-24 |
| brinzolamide | ANDA | 2024-07-10 |
| simbrinza | New Drug Application | 2023-05-16 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| open-angle glaucoma | EFO_0004190 | D005902 | H40.1 |
Agency Specific
FDA
EMA
No data
HCPCS
No data
Clinical
Clinical Trials
73 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glaucoma | D005901 | EFO_0000516 | H40 | 1 | 6 | 20 | 31 | 6 | 63 |
| Ocular hypertension | D009798 | EFO_1001069 | H40.0 | 1 | 6 | 17 | 18 | 6 | 47 |
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | 5 | 13 | 14 | 3 | 35 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 6 | 16 | 11 | 2 | 35 |
| Intraocular pressure | D007429 | — | — | — | — | — | 1 | 2 | 3 |
| Angle-closure glaucoma | D015812 | — | — | — | — | 2 | 1 | — | 3 |
| Capsule opacification | D058442 | — | H26.4 | — | — | — | 1 | — | 1 |
| Low tension glaucoma | D057066 | EFO_1001022 | H40.12 | — | — | — | 1 | — | 1 |
| Syndrome | D013577 | — | — | — | — | — | 1 | — | 1 |
| Congenital nystagmus | D020417 | EFO_0007217 | H55.01 | — | — | — | 1 | — | 1 |
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Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal dystrophies | D058499 | HP_0000556 | — | — | 1 | — | — | — | 1 |
| Central serous chorioretinopathy | D056833 | — | H35.71 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myopia | D009216 | EFO_0003927 | H52.1 | — | — | — | — | 2 | 2 |
| Exfoliation syndrome | D017889 | EFO_0004235 | — | — | — | — | — | 2 | 2 |
| Eye diseases | D005128 | EFO_0003966 | H44 | — | — | — | — | 1 | 1 |
| Cataract | D002386 | HP_0000518 | H26.9 | — | — | — | — | 1 | 1 |
| Retinoschisis | D041441 | — | H33.10 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Brinzolamide |
| INN | brinzolamide |
| Description | Brinzolamide is a sulfonamide and a thienothiazine. It has a role as an antiglaucoma drug and an EC 4.2.1.1 (carbonic anhydrase) inhibitor. |
| Classification | Small molecule |
| Drug class | carbonic anhydrase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(S(N)(=O)=O)cc21 |
Identifiers
| PDB | — |
| CAS-ID | 138890-62-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL220491 |
| ChEBI ID | 3176 |
| PubChem CID | 68844 |
| DrugBank | DB01194 |
| UNII ID | 9451Z89515 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CA2
CA2
Organism
Homo sapiens
Gene name
CA2
Gene synonyms
NCBI Gene ID
Protein name
carbonic anhydrase 2
Protein synonyms
CA-II, CAC, Carbonate dehydratase II, carbonic anhydrase B, Carbonic anhydrase C, Carbonic anhydrase II, carbonic dehydratase, Cyanamide hydratase CA2, epididymis luminal protein 76, epididymis secretory protein Li 282
Uniprot ID
Mouse ortholog
Car2 (12349)
carbonic anhydrase 2 (Q9DCY9)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Brinzolamide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,599 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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7,326 adverse events reported
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