Alunbrig(brigatinib)
Alunbrig (brigatinib) is a small molecule pharmaceutical. Brigatinib was first approved as Alunbrig on 2017-04-28. It is used to treat non-small-cell lung carcinoma in the USA. It has been approved in Europe to treat non-small-cell lung carcinoma.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| respiratory tract diseases | D012140 |
Trade Name
FDA
EMA
Alunbrig
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| alunbrig | New Drug Application | 2023-08-21 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| non-small-cell lung carcinoma | — | D002289 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
BRIGATINIB, ALUNBRIG, TAKEDA PHARMS USA | |||
| 2027-05-22 | ODE-300 | ||
| 2024-04-28 | ODE-142 | ||
HCPCS
No data
Clinical
Clinical Trials
39 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 4 | 13 | 2 | — | 8 | 26 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 3 | 3 | 1 | — | 2 | 9 |
| Neoplasms | D009369 | — | C80 | 2 | 4 | 1 | — | 1 | 6 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | 1 | — | 1 | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 2 | 3 | — | — | — | 3 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | — | 1 | — | — | — | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | 1 | — | — | — | 1 |
| Neurofibromatosis 2 | D016518 | — | Q85.02 | — | 1 | — | — | — | 1 |
| Acoustic neuroma | D009464 | HP_0009588 | — | — | 1 | — | — | — | 1 |
| Meningioma | D008579 | EFO_0003098 | D32.9 | — | 1 | — | — | — | 1 |
| Ependymoma | D004806 | — | — | — | 1 | — | — | — | 1 |
| Gene amplification | D005784 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gene rearrangement | D015321 | — | — | 2 | — | — | — | — | 2 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Brigatinib |
| INN | brigatinib |
| Description | Brigatinib, sold under the brand name Alunbrig among others, is a small-molecule targeted cancer therapy being developed by Ariad Pharmaceuticals, Inc. Brigatinib acts as both an anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR) inhibitor.
|
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 |
Identifiers
| PDB | — |
| CAS-ID | 1197953-54-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3545311 |
| ChEBI ID | — |
| PubChem CID | 68165256 |
| DrugBank | — |
| UNII ID | HYW8DB273J (ChemIDplus, GSRS) |
Target
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Variants
No data
Financial
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Alunbrig – Takeda
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Estimated US medical usage
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Trends
PubMed Central
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Additional graphs summarizing 2,413 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,324 adverse events reported
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