Therapeutic Area | MeSH |
---|---|
neoplasms | D009369 |
respiratory tract diseases | D012140 |
Brand Name | Status | Last Update |
---|---|---|
alunbrig | New Drug Application | 2024-10-24 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
non-small-cell lung carcinoma | — | D002289 | — |
Expiration | Code | ||
---|---|---|---|
BRIGATINIB, ALUNBRIG, TAKEDA PHARMS USA | |||
2027-05-22 | ODE-300 | ||
2024-04-28 | ODE-142 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Non-small-cell lung carcinoma | D002289 | — | — | 1 | 5 | 1 | — | 6 | 13 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Lung neoplasms | D008175 | — | C34.90 | 1 | 1 | — | — | 3 | 5 |
Lymphoma | D008223 | — | C85.9 | 2 | 2 | — | — | 2 | 4 |
Neoplasms | D009369 | — | C80 | 3 | 2 | — | — | — | 3 |
Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 2 | 2 | — | — | — | 2 |
Plasma cell granuloma | D006104 | — | — | 2 | 2 | — | — | — | 2 |
Neurofibromatosis 2 | D016518 | — | Q85.02 | — | 1 | — | — | — | 1 |
Acoustic neuroma | D009464 | — | — | — | 1 | — | — | — | 1 |
Meningioma | D008579 | EFO_0003098 | D32.9 | — | 1 | — | — | — | 1 |
Ependymoma | D004806 | — | — | — | 1 | — | — | — | 1 |
Neurofibromatosis 1 | D009456 | — | Q85.01 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Disease progression | D018450 | — | — | 1 | — | — | — | — | 1 |
Gene rearrangement | D015321 | — | — | 1 | — | — | — | — | 1 |
Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Drug common name | Brigatinib |
INN | brigatinib |
Description | Brigatinib, sold under the brand name Alunbrig among others, is a small-molecule targeted cancer therapy being developed by Ariad Pharmaceuticals, Inc. Brigatinib acts as both an anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR) inhibitor.
|
Classification | Small molecule |
Drug class | tyrosine kinase inhibitors |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 |
PDB | — |
CAS-ID | 1197953-54-0 |
RxCUI | — |
ChEMBL ID | CHEMBL3545311 |
ChEBI ID | — |
PubChem CID | 68165256 |
DrugBank | — |
UNII ID | HYW8DB273J (ChemIDplus, GSRS) |