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AboutPricing
Drug ReportsBretylium
Bretylium
Bretylol (bretylium) is a small molecule pharmaceutical. Bretylium was first approved as Bretylol on 1982-01-01. It is used to treat ventricular fibrillation and ventricular tachycardia in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bretylium tosylate
Tradename
Company
Number
Date
Products
BRETYLIUM TOSYLATE IN DEXTROSE 5%Abbott BiotherapeuticsN-019005 DISCN1986-04-29
3 products
BRETYLIUM TOSYLATE IN DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019121 DISCN1986-04-29
3 products
BRETYLIUM TOSYLATE IN DEXTROSE 5% IN PLASTIC CONTAINERBaxterN-019837 DISCN1989-04-12
2 products
BRETYLIUM TOSYLATEHospiraN-019030 DISCN1986-04-29
1 products, RLD
BRETYLIUM TOSYLATEHospiraN-019033 DISCN1986-04-29
1 products
BRETYLOLHospiraN-017954 DISCN1982-01-01
1 products
BRETYLIUM TOSYLATE IN DEXTROSE 5% IN PLASTIC CONTAINERHospiraN-019008 DISCN1986-04-29
3 products
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Labels
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Indications
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Indication
Ontology
MeSH
ICD-10
ventricular tachycardia—D017180I47.2
ventricular fibrillationHP_0001663D014693I49.01
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01B: Antiarrhythmics, class i and iii
— C01BD: Antiarrhythmics, class iii
— C01BD02: Bretylium tosilate
HCPCS
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Drug
General
Drug common nameBretylium
INNbretylium tosilate
Description
Bretylium is a quaternary ammonium cation having 2-bromobenzyl, ethyl and two methyl groups attached to the nitrogen. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. It has a role as an adrenergic antagonist, an anti-arrhythmia drug and an antihypertensive agent.
Classification
Small molecule
Drug classquaternary ammonium derivatives
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Structure (InChI/SMILES or Protein Sequence)
CC[N+](C)(C)Cc1ccccc1Br
Identifiers
PDB—
CAS-ID59-41-6
RxCUI—
ChEMBL IDCHEMBL1199080
ChEBI ID3172
PubChem CID2431
DrugBankDB01158
UNII ID78ZP3YR353 (ChemIDplus, GSRS)
Target
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PubMed Central
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Safety
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2 adverse events reported
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