Brepocitinib
Brepocitinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target tyrosine-protein kinase JAK2, non-receptor tyrosine-protein kinase TYK2, tyrosine-protein kinase JAK3, and tyrosine-protein kinase JAK1.
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Clinical
Clinical Trials
25 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Uveitis | D014605 | HP_0000554 | H20.9 | — | 1 | 1 | — | — | 2 |
| Intermediate uveitis | D015867 | EFO_1000986 | — | — | 1 | 1 | — | — | 2 |
| Posterior uveitis | D015866 | EFO_1001119 | — | — | 1 | 1 | — | — | 2 |
| Pars planitis | D015868 | EFO_1001088 | H30.2 | — | 1 | 1 | — | — | 2 |
| Dermatomyositis | D003882 | EFO_0000398 | M33 | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriasis | D011565 | EFO_0000676 | L40 | 1 | 2 | — | — | — | 3 |
| Alopecia areata | D000506 | EFO_0004192 | L63 | — | 2 | — | — | — | 2 |
| Alopecia | D000505 | HP_0002293 | L64 | — | 2 | — | — | — | 2 |
| Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | — | 1 | — | — | — | 1 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | 1 | — | — | — | 1 |
| Vitiligo | D014820 | EFO_0004208 | L80 | — | 1 | — | — | — | 1 |
| Hidradenitis suppurativa | D017497 | — | L73.2 | — | 1 | — | — | — | 1 |
| Hidradenitis | D016575 | — | — | — | 1 | — | — | — | 1 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | 1 | — | — | — | 1 |
| Eczema | D004485 | HP_0000964 | L30.9 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 8 | — | — | — | — | 8 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Brepocitinib |
| INN | brepocitinib |
| Description | Brepocitinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target tyrosine-protein kinase JAK2, non-receptor tyrosine-protein kinase TYK2, tyrosine-protein kinase JAK3, and tyrosine-protein kinase JAK1. |
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors: tyrosine kinase inhibitors; janus kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cn1cc(Nc2nccc(N3C[C@@H]4CC[C@H](C3)N4C(=O)[C@@H]3CC3(F)F)n2)cn1 |
Identifiers
| PDB | — |
| CAS-ID | 1883299-62-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297477 |
| ChEBI ID | — |
| PubChem CID | 118878093 |
| DrugBank | DB15003 |
| UNII ID | 3X8387Q25N (ChemIDplus, GSRS) |
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