Tradename | Company | Number | Date | Products |
---|---|---|---|---|
BOSULIF | CV Sciences | N-217729 RX | 2023-09-26 | 2 products, RLD, RS |
BOSULIF | CV Sciences | N-203341 RX | 2012-09-04 | 3 products, RLD |
Brand Name | Status | Last Update |
---|---|---|
bosulif | New Drug Application | 2024-12-19 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
bcr-abl positive chronic myelogenous leukemia | EFO_0000340 | D015464 | — |
Expiration | Code | ||
---|---|---|---|
BOSUTINIB MONOHYDRATE, BOSULIF, PF PRISM CV | |||
2024-12-19 | ODE-163 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 3 | 7 | 2 | 1 | 5 | 16 |
Myeloid leukemia | D007951 | — | C92 | 2 | 6 | 1 | 1 | 6 | 14 |
Leukemia | D007938 | — | C95 | 2 | 6 | 2 | 1 | 3 | 12 |
Philadelphia chromosome | D010677 | — | — | 2 | 3 | 1 | 1 | — | 6 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Myeloid leukemia chronic-phase | D015466 | — | — | 2 | 5 | 1 | — | — | 6 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 4 | — | — | — | 5 |
Neoplasms | D009369 | — | C80 | 1 | 2 | — | — | — | 3 |
Glioblastoma | D005909 | EFO_0000515 | — | 1 | 2 | — | — | — | 2 |
Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 1 | — | — | — | 1 |
Multiple myeloma | D009101 | — | C90.0 | — | 1 | — | — | — | 1 |
Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | 1 | 1 | — | — | — | 1 |
Motor neuron disease | D016472 | EFO_0003782 | G12.2 | 1 | 1 | — | — | — | 1 |
Sclerosis | D012598 | — | — | 1 | 1 | — | — | — | 1 |
Myeloid leukemia accelerated phase | D015465 | — | — | 1 | 1 | — | — | — | 1 |
Blast crisis | D001752 | — | — | 1 | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 6 | — | — | — | — | 6 |
Malnutrition | D044342 | EFO_0008572 | E40-E46 | 2 | — | — | — | — | 2 |
Dementia | D003704 | EFO_0003862 | F03 | 1 | — | — | — | — | 1 |
Cognitive dysfunction | D060825 | — | G31.84 | 1 | — | — | — | — | 1 |
Chronic renal insufficiency | D051436 | — | N18 | 1 | — | — | — | — | 1 |
Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 1 | — | — | — | — | 1 |
Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
Acute kidney injury | D058186 | — | N17 | 1 | — | — | — | — | 1 |
Drug common name | Bosutinib |
INN | bosutinib |
Description | Bosutinib is an aminoquinoline that is 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline bearing additional cyano and methoxy substituents at positions 3 and 6 respectively. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It is a nitrile, a N-methylpiperazine, an aromatic ether, a tertiary amino compound, an aminoquinoline and a dichlorobenzene. |
Classification | Small molecule |
Drug class | tyrosine kinase inhibitors |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl |
PDB | — |
CAS-ID | 380843-75-4 |
RxCUI | — |
ChEMBL ID | CHEMBL288441 |
ChEBI ID | 39112 |
PubChem CID | 5328940 |
DrugBank | DB06616 |
UNII ID | 5018V4AEZ0 (ChemIDplus, GSRS) |