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Drug ReportsBosutinib
Bosulif(bosutinib)
Bosulif (bosutinib) is a small molecule pharmaceutical. Bosutinib was first approved as Bosulif on 2012-09-04. It is used to treat BCR-ABL positive chronic myelogenous leukemia in the USA. It has been approved in Europe to treat myeloid leukemia. The pharmaceutical is active against tyrosine-protein kinase ABL1. In addition, it is known to target calcium/calmodulin-dependent protein kinase type 1D, serine/threonine-protein kinase 24, tyrosine-protein kinase Fyn, activated CDC42 kinase 1, serine/threonine-protein kinase 4, putative serine/threonine-protein kinase SIK1B, serine/threonine-protein kinase 10, calcium/calmodulin-dependent protein kinase type II subunit gamma, mitogen-activated protein kinase kinase kinase kinase 5, serine/threonine-protein kinase SIK2, serine/threonine-protein kinase SIK3, tyrosine-protein kinase TXK, proto-oncogene tyrosine-protein kinase Src, tyrosine-protein kinase FRK, and tyrosine-protein kinase Lyn.
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Financial
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Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
hemic and lymphatic diseasesD006425
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Bosulif
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bosutinib monohydrate
Tradename
Company
Number
Date
Products
BOSULIFCV SciencesN-217729 RX2023-09-26
2 products, RLD, RS
BOSULIFCV SciencesN-203341 RX2012-09-04
3 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
bosulifNew Drug Application2024-12-19
Indications
FDA
EMA
Agency Specific
FDA
EMA
Expiration
Code
BOSUTINIB MONOHYDRATE, BOSULIF, PF PRISM CV
2024-12-19ODE-163
Patent Expiration
Patent
Expires
Flag
FDA Information
Bosutinib Monohydrate, Bosulif, Pf Prism Cv
111034972034-02-28U-3216, U-3217
77676782026-11-23DS, DP
74171482025-12-11U-1283
79196252025-12-11DP
RE423762024-04-13DP
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01E: Protein kinase inhibitors, antineoplastic and immunomodulating agents
— L01EA: Bcr-abl tyrosine kinase inhibitors
— L01EA04: Bosutinib
HCPCS
No data
Clinical
Clinical Trials
77 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_0000340—3721516
Myeloid leukemiaD007951—C922611614
LeukemiaD007938—C952621312
Philadelphia chromosomeD010677——2311—6
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemia chronic-phaseD015466——251——6
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5024———5
NeoplasmsD009369—C8012———3
GlioblastomaD005909EFO_0000515—12———2
Non-hodgkin lymphomaD008228—C85.9—1———1
Multiple myelomaD009101—C90.0—1———1
Amyotrophic lateral sclerosisD000690EFO_0000253G12.2111———1
Motor neuron diseaseD016472EFO_0003782G12.211———1
SclerosisD012598——11———1
Myeloid leukemia accelerated phaseD015465——11———1
Blast crisisD001752——11———1
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———6————6
MalnutritionD044342EFO_0008572E40-E462————2
DementiaD003704EFO_0003862F031————1
Cognitive dysfunctionD060825—G31.841————1
Chronic renal insufficiencyD051436—N181————1
Chronic kidney failureD007676EFO_0003884N18.61————1
Renal insufficiencyD051437—N191————1
Acute kidney injuryD058186—N171————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBosutinib
INNbosutinib
Description
Bosutinib is an aminoquinoline that is 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline bearing additional cyano and methoxy substituents at positions 3 and 6 respectively. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It is a nitrile, a N-methylpiperazine, an aromatic ether, a tertiary amino compound, an aminoquinoline and a dichlorobenzene.
Classification
Small molecule
Drug classtyrosine kinase inhibitors
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Structure (InChI/SMILES or Protein Sequence)
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl
Identifiers
PDB—
CAS-ID380843-75-4
RxCUI—
ChEMBL IDCHEMBL288441
ChEBI ID39112
PubChem CID5328940
DrugBankDB06616
UNII ID5018V4AEZ0 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
SRC
SRC
TNK2
TNK2
CAMK1D
CAMK1D
FYN
FYN
CAMK2G
CAMK2G
Organism
Homo sapiens
Gene name
SRC
Gene synonyms
SRC1
NCBI Gene ID
Protein name
proto-oncogene tyrosine-protein kinase Src
Protein synonyms
p60-Src, pp60c-src, Proto-oncogene c-Src, protooncogene SRC, Rous sarcoma, tyrosine kinase pp60c-src, tyrosine-protein kinase SRC-1, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Uniprot ID
Mouse ortholog
Src (20779)
proto-oncogene tyrosine-protein kinase Src (Q2M4I4)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Bosulif – Pfizer
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Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,263 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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7,708 adverse events reported
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