Velcade(bortezomib)
Velcade (bortezomib) is a small molecule pharmaceutical. Bortezomib was first approved as Velcade on 2003-05-13. It is used to treat mantle-cell lymphoma and multiple myeloma in the USA. It has been approved in Europe to treat multiple myeloma. The pharmaceutical is active against proteasome subunit beta type-5.
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Commercial
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Trade Name
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Velcade (generic drugs available since 2022-05-02)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bortezomib
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bortezomib | ANDA | 2023-12-29 |
| velcade | New Drug Application | 2022-10-25 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| mantle-cell lymphoma | — | D020522 | C83.1 |
| multiple myeloma | — | D009101 | C90.0 |
Agency Specific
FDA
EMA
No data
Clinical
Clinical Trials
1027 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 134 | 268 | 97 | 14 | 54 | 499 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 14 | 13 | 4 | 1 | 3 | 32 |
| Waldenstrom macroglobulinemia | D008258 | HP_0005508 | C88.0 | 8 | 16 | 1 | 1 | 1 | 25 |
| Immunoglobulin light-chain amyloidosis | D000075363 | — | — | 2 | 4 | 6 | 1 | 1 | 14 |
| Hematologic neoplasms | D019337 | — | — | 6 | 5 | — | 2 | 3 | 12 |
| Kidney transplantation | D016030 | — | — | 2 | 3 | 1 | 1 | — | 5 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 1 | — | 1 | — | 2 |
| Residual neoplasm | D018365 | — | — | — | — | — | 1 | 1 | 2 |
| Iga glomerulonephritis | D005922 | EFO_0004194 | — | — | — | — | 1 | 1 | 2 |
| Healthy volunteers/patients | — | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mantle-cell lymphoma | D020522 | — | C83.1 | 21 | 37 | 2 | — | 2 | 54 |
| Lymphoma | D008223 | — | C85.9 | 22 | 30 | 1 | — | 1 | 49 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 20 | 19 | 1 | — | 2 | 37 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 15 | 10 | 1 | — | 2 | 25 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 10 | 12 | 2 | — | 1 | 22 |
| Leukemia | D007938 | — | C95 | 11 | 8 | 1 | — | — | 18 |
| Amyloidosis | D000686 | EFO_1001875 | E85 | 1 | 8 | 4 | — | 4 | 15 |
| Peripheral nervous system diseases | D010523 | HP_0009830 | G64 | — | 2 | 1 | — | 3 | 6 |
| Thrombocytopenic purpura idiopathic | D016553 | EFO_0007160 | D69.3 | — | 1 | 1 | — | — | 2 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 1 | 1 | — | — | 2 |
Show 3 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 45 | 11 | — | — | 1 | 52 |
| Follicular lymphoma | D008224 | — | C82 | 10 | 18 | — | — | 2 | 27 |
| Plasma cell neoplasms | D054219 | — | — | 13 | 16 | — | — | — | 25 |
| Non-small-cell lung carcinoma | D002289 | — | — | 7 | 16 | — | — | — | 21 |
| Myelodysplastic syndromes | D009190 | — | D46 | 11 | 8 | — | — | 1 | 18 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 10 | 5 | — | — | 2 | 16 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 7 | 5 | — | — | 1 | 12 |
| Hodgkin disease | D006689 | — | C81 | 7 | 5 | — | — | — | 12 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 6 | 4 | — | — | 1 | 11 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 8 | 6 | — | — | — | 11 |
Show 105 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 5 | — | — | — | — | 5 |
| Lymphomatoid granulomatosis | D008230 | — | C83.8 | 4 | — | — | — | 1 | 5 |
| Large-cell lymphoma immunoblastic | D016400 | — | — | 3 | — | — | — | 1 | 4 |
| Fallopian tube neoplasms | D005185 | — | — | 3 | — | — | — | — | 3 |
| Anemia | D000740 | HP_0001903 | D64.9 | 2 | — | — | — | — | 2 |
| Intraocular lymphoma | D064090 | — | — | 1 | — | — | — | 1 | 2 |
| Astrocytoma | D001254 | EFO_0000271 | — | 2 | — | — | — | — | 2 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 2 | — | — | — | — | 2 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 1 | — | — | — | — | 1 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 1 | — | — | — | — | 1 |
Show 32 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | HP_0001635 | I50 | — | — | — | — | 1 | 1 |
| Hairy cell leukemia | D007943 | — | C91.4 | — | — | — | — | 1 | 1 |
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | — | — | — | — | 1 | 1 |
| Hemoglobin sc disease | D006450 | EFO_1001797 | D57.2 | — | — | — | — | 1 | 1 |
| Glomerulonephritis | D005921 | HP_0000099 | N05 | — | — | — | — | 1 | 1 |
| Membranoproliferative glomerulonephritis | D015432 | — | — | — | — | — | — | 1 | 1 |
| Survivorship | D000073859 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bortezomib |
| INN | bortezomib |
| Description | Bortezomib is l-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome. It has a role as an antineoplastic agent, a proteasome inhibitor, a protease inhibitor and an antiprotozoal drug. It is an amino acid amide, a member of pyrazines and a L-phenylalanine derivative. It is functionally related to a boronic acid. |
| Classification | Small molecule |
| Drug class | proteozome inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |
Identifiers
| PDB | — |
| CAS-ID | 179324-69-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL325041 |
| ChEBI ID | 52717 |
| PubChem CID | 387447 |
| DrugBank | DB00188 |
| UNII ID | 69G8BD63PP (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PSMB1
PSMB1
Organism
Homo sapiens
Gene name
PSMB1
Gene synonyms
PSC5
NCBI Gene ID
Protein name
proteasome subunit beta type-1
Protein synonyms
Macropain subunit C5, Multicatalytic endopeptidase complex subunit C5, proteasome (prosome, macropain) subunit, beta type, 1, proteasome beta 1 subunit, Proteasome component C5, Proteasome gamma chain, proteasome subunit beta 1, proteasome subunit beta6, proteasome subunit HC5, testicular secretory protein Li 45
Uniprot ID
Mouse ortholog
Psmb1 (19170)
proteasome subunit beta type-1 (Q62039)
Variants
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Velcade – Takeda
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Velcade – Johnson & Johnson
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Trends
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Safety
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Adverse Events
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47,551 adverse events reported
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