Biotin
Berocca Pn, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Vitaped (biotin) is a small molecule pharmaceutical. Biotin was first approved as M.v.i.-12 lyophilized on 1985-08-08. It is used to treat inborn errors metabolism and vitamin b deficiency in the USA. It is known to target urotensin-2 receptor.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Combinations
Infuvite (discontinued: Berocca pn, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Vitaped)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alpha-tocopherol acetate
+
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin k
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Tocopherol acetate
+
Vitamin a
+
Vitamin k
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Phytonadione
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin 5'-phosphate sodium
+
Thiamine
+
Vitamin a
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
+
Vitamin k
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin e
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 1.8oz armstrong hand sanitizer with aloe vera and vitamin e | OTC monograph not final | 2017-12-15 |
| 2 pack assured instant hand sanitizer with moisturizers (vitamin e and aloe) | OTC monograph not final | 2014-11-02 |
| 25 person ansi | OTC monograph final | 2010-06-07 |
| 3 hand sanitizers | OTC monograph not final | 2014-11-15 |
| 3 pack assured instant hand sanitizer with moisturizers (vitamin e and aloe) | OTC monograph not final | 2014-11-02 |
| 3 pack assured instant hand sanitizer with moisturizers (vitamin e and moisturizers) | OTC monograph not final | 2014-11-02 |
| 3 pack family dollar instant hand sanitizers | OTC monograph not final | 2014-11-28 |
| 50 person ansi | OTC monograph final | 2010-06-07 |
| 574h cell care | unapproved drug other | 2020-06-19 |
| 7-11 instant hand sanitizer with aloe and vitamin e | OTC monograph not final | 2011-11-02 |
Show 381 more
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| inborn errors metabolism | — | D008661 | — |
| vitamin b deficiency | — | D014804 | E53.9 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
300 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 4 | 18 | 12 | 1 | 1 | 35 |
| Neoplasms | D009369 | — | C80 | 9 | 2 | 1 | 3 | — | 15 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | 1 | — | 3 | 2 | 6 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | 1 | 4 | — | 5 |
| Pregnancy rate | D018873 | — | — | — | — | — | 1 | 2 | 3 |
| St elevation myocardial infarction | D000072657 | — | — | — | — | 1 | 1 | — | 2 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | — | — | 1 | 1 | — | 2 |
| Infertility | D007246 | HP_0000789 | — | — | — | 1 | 1 | — | 2 |
| Percutaneous coronary intervention | D062645 | — | — | — | — | — | 2 | — | 2 |
| Coronary disease | D003327 | — | — | — | — | — | 1 | — | 1 |
Show 10 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 2 | 3 | 3 | — | — | 8 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 4 | 2 | — | — | 7 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 2 | 4 | 2 | — | 1 | 7 |
| Adenocarcinoma | D000230 | — | — | 1 | 5 | 1 | — | — | 6 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | 3 | — | 3 | 6 |
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | 1 | 1 | — | — | 4 |
| Prostatic neoplasms | D011471 | — | C61 | 3 | 1 | 1 | — | — | 4 |
| Colonic neoplasms | D003110 | — | C18 | 1 | 2 | 1 | — | — | 3 |
| Leukemia | D007938 | — | C95 | — | 1 | 2 | — | — | 3 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | 1 | — | 2 | 3 |
Show 25 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 10 | 2 | — | — | 5 | 17 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 5 | 2 | — | — | — | 5 |
| Rectal neoplasms | D012004 | — | — | 1 | 5 | — | — | — | 5 |
| Melanoma | D008545 | — | — | 4 | 1 | — | — | — | 4 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | 3 | 4 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 1 | — | — | — | 3 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | 1 | — | — | 2 | 3 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 1 | 1 | — | — | — | 2 |
| Myeloid leukemia chronic-phase | D015466 | — | — | 1 | 1 | — | — | — | 2 |
| Cholangiocarcinoma | D018281 | — | C22.1 | 1 | 1 | — | — | — | 2 |
Show 36 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | HP_0001903 | D64.9 | 5 | — | — | — | 1 | 6 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 4 | — | — | — | — | 4 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 4 | — | — | — | — | 4 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | — | — | — | — | 3 |
| Non-small-cell lung carcinoma | D002289 | — | — | 3 | — | — | — | — | 3 |
| Hematologic neoplasms | D019337 | — | — | 2 | — | — | — | — | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 2 | — | — | — | — | 2 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 2 | — | — | — | — | 2 |
| Fallopian tube neoplasms | D005185 | — | — | 2 | — | — | — | — | 2 |
| Triple negative breast neoplasms | D064726 | — | — | 2 | — | — | — | — | 2 |
Show 28 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin b 12 deficiency | D014806 | EFO_0000734 | E53.8 | — | — | — | — | 3 | 3 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 2 | 2 |
| Depression | D003863 | — | F33.9 | — | — | — | — | 2 | 2 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | — | — | 2 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 2 | 2 |
| Nutritional requirements | D009751 | — | — | — | — | — | — | 2 | 2 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | — | — | — | 1 | 1 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | — | — | — | 1 | 1 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 1 | 1 |
| Avitaminosis | D001361 | EFO_0005878 | E56.9 | — | — | — | — | 1 | 1 |
Show 44 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Biotin |
| INN | biotin |
| Description | Biotin is an organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins. It has a role as a prosthetic group, a coenzyme, a nutraceutical, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a mouse metabolite, a cofactor and a fundamental metabolite. It is a member of biotins and a vitamin B7. It is a conjugate acid of a biotinate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 |
Identifiers
| PDB | — |
| CAS-ID | 58-85-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL857 |
| ChEBI ID | 15956 |
| PubChem CID | 171548 |
| DrugBank | DB00121 |
| UNII ID | 6SO6U10H04 (ChemIDplus, GSRS) |
Target
Variants
No data
Financial
Revenue by drug
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€
£
â‚£
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Estimated US medical usage
Biotin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 246,415 documents
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Safety
Black-box Warning
Black-box warning for: Citranatal assure, Citranatal essence, Neonatal19, Nestabs, Pnv prenatal plus multivitamin, Pnv prenatal vitamin, Pnv-select, Prenate elite, Prenate enhance, Prenate essential, Prenate mini, Prenate pixie, Prenate restore, Primacare, Select ob, Select-ob plus dha, Vitafol, Vitafol ob, Vitafol-ob plus dha
Adverse Events
Top Adverse Reactions
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619 adverse events reported
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