Bimzelx(bimekizumab)
Bimzelx (bimekizumab) is an antibody pharmaceutical. Bimekizumab was first approved as Bimzelx on 2021-08-20. It is used to treat psoriasis in the USA. It has been approved in Europe to treat psoriasis. The pharmaceutical is active against interleukin-17A and interleukin-17F.
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Events Timeline
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YTD
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
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Completion date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| skin and connective tissue diseases | D017437 |
Trade Name
FDA
EMA
Bimzelx
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bimzelx | Biologic Licensing Application | 2024-09-25 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| psoriasis | EFO_0000676 | D011565 | L40 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
45 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriasis | D011565 | EFO_0000676 | L40 | 1 | 5 | 10 | 3 | 1 | 20 |
| Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | 1 | 2 | 9 | 1 | 1 | 14 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | 1 | 3 | 6 | 1 | 1 | 12 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spondylarthritis | D025241 | — | — | — | 3 | 4 | — | — | 7 |
| Spondylitis | D013166 | — | M46.9 | — | 3 | 4 | — | — | 7 |
| Ankylosing spondylitis | D013167 | EFO_0003898 | M45 | — | 3 | 3 | — | — | 6 |
| Hidradenitis suppurativa | D017497 | — | L73.2 | — | 1 | 3 | — | — | 4 |
| Hidradenitis | D016575 | — | — | — | 1 | 3 | — | — | 4 |
| Non-radiographic axial spondyloarthritis | D000089202 | — | — | — | — | 2 | — | — | 2 |
| Axial spondyloarthritis | D000089183 | — | — | — | — | 2 | — | — | 2 |
| Juvenile arthritis | D001171 | EFO_1002007 | M08 | — | — | 1 | — | — | 1 |
| Enthesopathy | D000070676 | — | M77.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | — | 5 |
| Human influenza | D007251 | EFO_0007328 | J11.1 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bimekizumab |
| INN | bimekizumab |
| Description | Bimekizumab, sold under the brand name Bimzelx, is a humanized anti-IL17A, anti-IL-17F, and anti-IL17AF monoclonal antibody that is used to treat plaque psoriasis, psoriatic arthritis, axial spondyloarthritis, and ankylosing spondylitis.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297700 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB12917 |
| UNII ID | 09495UIM6V (ChemIDplus, GSRS) |
Target
Agency Approved
IL17A
IL17A
IL17F
IL17F
Organism
Homo sapiens
Gene name
IL17A
Gene synonyms
CTLA8, IL17
NCBI Gene ID
Protein name
interleukin-17A
Protein synonyms
CTLA-8, Cytotoxic T-lymphocyte-associated antigen 8, cytotoxic T-lymphocyte-associated protein 8, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8), interleukin-17
Uniprot ID
Mouse ortholog
Il17a (16171)
interleukin-17A (Q62386)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 739 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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328 adverse events reported
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