Targretin(bexarotene)
Bexarotene, Targretin (bexarotene) is a small molecule pharmaceutical. Bexarotene was first approved as Targretin on 1999-12-29. It is used to treat t-cell lymphoma cutaneous in the USA. It has been approved in Europe to treat t-cell lymphoma cutaneous. The pharmaceutical is active against retinoic acid receptor RXR-gamma, retinoic acid receptor RXR-alpha, and retinoic acid receptor RXR-beta. In addition, it is known to target peroxisome proliferator-activated receptor gamma.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Bexarotene, Targretin (discontinued: Bexarotene)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bexarotene
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TARGRETIN | Bausch Health Companies | N-021056 RX | 2000-06-28 | 1 products, RLD, RS |
| TARGRETIN | Bausch Health Companies | N-021055 RX | 1999-12-29 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bexarotene | ANDA | 2024-11-27 |
| targretin | New Drug Application | 2020-04-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| t-cell lymphoma cutaneous | — | D016410 | C84.A |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
47 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | — | — | — | 1 | — | 1 |
| T-cell lymphoma | D016399 | — | — | — | — | — | 1 | — | 1 |
| T-cell lymphoma peripheral | D016411 | — | — | — | — | — | 1 | — | 1 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bexarotene |
| INN | bexarotene |
| Description | Bexarotene is a retinoid, a member of benzoic acids and a member of naphthalenes. It has a role as an antineoplastic agent. |
| Classification | Small molecule |
| Drug class | arotinoid derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C |
Identifiers
| PDB | — |
| CAS-ID | 153559-49-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1023 |
| ChEBI ID | 50859 |
| PubChem CID | 82146 |
| DrugBank | DB00307 |
| UNII ID | A61RXM4375 (ChemIDplus, GSRS) |
Target
Agency Approved
Alternate
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Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 3,674 documents
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Safety
Black-box Warning
Black-box warning for: Bexarotene, Targretin
Adverse Events
Top Adverse Reactions
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1,094 adverse events reported
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