Targretin(bexarotene)
Bexarotene, Targretin (bexarotene) is a small molecule pharmaceutical. Bexarotene was first approved as Targretin on 1999-12-29. It is used to treat t-cell lymphoma cutaneous in the USA. It has been approved in Europe to treat t-cell lymphoma cutaneous. The pharmaceutical is active against retinoic acid receptor RXR-gamma, retinoic acid receptor RXR-alpha, and retinoic acid receptor RXR-beta. In addition, it is known to target peroxisome proliferator-activated receptor gamma.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Targretin (generic drugs available since 2014-08-12)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bexarotene
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TARGRETIN | Bausch Health Companies | N-021056 RX | 2000-06-28 | 1 products, RLD, RS |
| TARGRETIN | Bausch Health Companies | N-021055 RX | 1999-12-29 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bexarotene | ANDA | 2024-07-31 |
| targretin | New Drug Application | 2020-04-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| t-cell lymphoma cutaneous | — | D016410 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
47 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 5 | 8 | 2 | 2 | 1 | 17 |
| T-cell lymphoma cutaneous | D016410 | — | — | 4 | 8 | 1 | 2 | 1 | 15 |
| T-cell lymphoma | D016399 | — | — | 4 | 8 | 1 | 2 | — | 14 |
| T-cell lymphoma peripheral | D016411 | — | — | 3 | 4 | 1 | 2 | — | 9 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | — | — | 1 | — | 1 |
| Hypertriglyceridemia | D015228 | EFO_0004211 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 4 | 2 | — | 1 | 7 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | 4 | 2 | — | 1 | 7 |
| Mycosis fungoides | D009182 | — | C84.0 | 2 | 1 | 3 | — | 1 | 7 |
| Mycoses | D009181 | — | B35-B49 | 1 | 1 | 3 | — | 1 | 6 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 1 | — | 1 | — | 1 | 3 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 3 | — | — | 3 |
| Sezary syndrome | D012751 | — | C84.1 | 1 | 1 | 1 | — | — | 3 |
| Primary cutaneous anaplastic large cell lymphoma | D054446 | — | C86.6 | 1 | — | 1 | — | — | 2 |
| Syndrome | D013577 | — | — | — | 1 | 1 | — | — | 2 |
| Psychotic disorders | D011618 | — | F20.81 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 2 | 2 | — | — | 1 | 5 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 1 | — | — | 1 | 4 |
| Myeloid leukemia | D007951 | — | C92 | 2 | 1 | — | — | 1 | 4 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 1 | — | — | — | 4 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 1 | — | — | — | 2 |
| Pituitary acth hypersecretion | D047748 | EFO_1001110 | E24.0 | 1 | 1 | — | — | — | 1 |
| Acth-secreting pituitary adenoma | D049913 | — | — | 1 | 1 | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | — | 1 | — | — | — | 1 |
| Myeloproliferative disorders | D009196 | — | D47.1 | — | 1 | — | — | — | 1 |
| Myelodysplastic-myeloproliferative diseases | D054437 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Triple negative breast neoplasms | D064726 | — | — | 1 | — | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
| Carcinoma in situ | D002278 | — | D09.9 | 1 | — | — | — | — | 1 |
| Breast carcinoma in situ | D000071960 | — | D05 | 1 | — | — | — | — | 1 |
| Lobular carcinoma | D018275 | EFO_0000570 | — | 1 | — | — | — | — | 1 |
| Ductal carcinoma breast | D018270 | — | — | 1 | — | — | — | — | 1 |
| Ductal carcinoma | D044584 | — | — | 1 | — | — | — | — | 1 |
| Intraductal carcinoma noninfiltrating | D002285 | — | D05.1 | 1 | — | — | — | — | 1 |
| Invasive hydatidiform mole | D002820 | — | D39.2 | 1 | — | — | — | — | 1 |
| Hyperplasia | D006965 | EFO_0000536 | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | — | — | — | — | 1 | 1 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | — | — | — | — | 1 | 1 |
| Acute disease | D000208 | — | — | — | — | — | — | 1 | 1 |
| Lymphoid leukemia | D007945 | — | C91 | — | — | — | — | 1 | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | — | — | — | 1 | 1 |
| Follicular lymphoma | D008224 | — | C82 | — | — | — | — | 1 | 1 |
| Lymphomatoid papulosis | D017731 | — | C86.6 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bexarotene |
| INN | bexarotene |
| Description | Bexarotene is a retinoid, a member of benzoic acids and a member of naphthalenes. It has a role as an antineoplastic agent. |
| Classification | Small molecule |
| Drug class | arotinoid derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C |
Identifiers
| PDB | — |
| CAS-ID | 153559-49-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1023 |
| ChEBI ID | 50859 |
| PubChem CID | 82146 |
| DrugBank | DB00307 |
| UNII ID | A61RXM4375 (ChemIDplus, GSRS) |
Target
Agency Approved
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Bexarotene, Targretin
Adverse Events
Top Adverse Reactions
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1,049 adverse events reported
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