Avastin(bevacizumab)
Abevmy, Alymsys, Avastin, Avzivi, Aybintio, Mvasi, Onbevzi, Oyavas, Vegzelma, Zirabev (bevacizumab) is an antibody pharmaceutical. Bevacizumab was first approved as Lextemy on . It is used to treat colorectal neoplasms, fallopian tube neoplasms, glioblastoma, kidney neoplasms, and non-small-cell lung carcinoma amongst others in the USA. It has been approved in Europe to treat breast neoplasms, colorectal neoplasms, fallopian tube neoplasms, non-small-cell lung carcinoma, and ovarian neoplasms amongst others. The pharmaceutical is active against vascular endothelial growth factor A, long form. In addition, it is known to target Vascular permeability factor.
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
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Completion date
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Commercial
Trade Name
FDA
EMA
Alymsys, Avastin, Mvasi, Vegzelma, Zirabev
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| alymsys | Biologic Licensing Application | 2022-04-27 |
| avastin | Biologic Licensing Application | 2025-01-06 |
| avzivi | Biologic Licensing Application | 2024-10-09 |
| mvasi | Biologic Licensing Application | 2024-10-31 |
| vegzelma | Biologic Licensing Application | 2023-02-22 |
| zirabev | Biologic Licensing Application | 2025-01-22 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
bevacizumab, Avastin, Genentech, Inc. | |||
| 2027-05-29 | Orphan excl. | ||
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01F: Monoclonal antibodies and antibody drug conjugates
— L01FG: Vegf/vegfr (vascular endothelial growth factor) inhibitors
— L01FG01: Bevacizumab
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01L: Ocular vascular disorder agents
— S01LA: Antineovascularisation agents
— S01LA08: Bevacizumab
Clinical
Clinical Trials
3478 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 1 | 7 | 5 | — | — | 12 |
| Neoplasms | D009369 | — | C80 | 3 | 4 | 1 | — | — | 8 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 4 | 2 | — | — | 6 |
| Colonic neoplasms | D003110 | — | C18 | 1 | 5 | 1 | — | — | 6 |
| Rectal neoplasms | D012004 | — | — | 1 | 5 | 1 | — | — | 6 |
| Lung neoplasms | D008175 | — | C34.90 | — | 1 | 2 | — | — | 3 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 2 | 1 | — | — | 3 |
| Neutropenia | D009503 | — | D70 | — | — | 1 | — | — | 1 |
| Fever | D005334 | — | R50.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 4 | — | — | — | 4 |
| Recurrence | D012008 | — | — | — | 2 | — | — | — | 2 |
| Sarcoma | D012509 | — | — | 1 | 1 | — | — | — | 2 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 2 | — | — | — | 2 |
| Mucinous adenocarcinoma | D002288 | — | — | — | 1 | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | — | 1 | — | — | — | 1 |
| Cystadenocarcinoma | D003536 | — | — | — | 1 | — | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | — | 1 | — | — | — | 1 |
| Carcinoid tumor | D002276 | — | D3A.00 | — | 1 | — | — | — | 1 |
| Oncogenes | D009857 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bevacizumab |
| INN | bevacizumab |
| Description | Bevacizumab, sold under the brand name Avastin, is a medication used to treat a number of types of cancers and a specific eye disease. For cancer it is given by slow injection into a vein and used for colon cancer, lung cancer, glioblastoma, and renal-cell carcinoma. For age-related macular degeneration it is given by injection into the eye.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >7V5N:A,E|bevacizumab fab light chain
DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
>7V5N:B,F|bevacizumab fab heavy chain
EVQLVESGGGLVQPGGSLRLSCAASGYTFTNYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAY
LQMNSLRAEDTAVYYCAKYPHYYGSSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV
TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT |
Identifiers
| PDB | 6BFT, 7V5N |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201583 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00112 |
| UNII ID | 2S9ZZM9Q9V (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
VEGFA
VEGFA
Organism
Homo sapiens
Gene name
VEGFA
Gene synonyms
NCBI Gene ID
—
Protein name
Vascular endothelial growth factor A
Protein synonyms
Vascular permeability factor
Uniprot ID
Mouse ortholog
—
—
Variants
No data
Financial
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 94,733 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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122,933 adverse events reported
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