Avastin(bevacizumab)
Abevmy, Alymsys, Avastin, Avzivi, Aybintio, Mvasi, Onbevzi, Oyavas, Vegzelma, Zirabev (bevacizumab) is an antibody pharmaceutical. Bevacizumab was first approved as Lextemy on . It is used to treat colorectal neoplasms, fallopian tube neoplasms, glioblastoma, kidney neoplasms, and non-small-cell lung carcinoma amongst others in the USA. It has been approved in Europe to treat breast neoplasms, colorectal neoplasms, fallopian tube neoplasms, non-small-cell lung carcinoma, and ovarian neoplasms amongst others. The pharmaceutical is active against vascular endothelial growth factor A, long form. In addition, it is known to target Vascular permeability factor.
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Commercial
Trade Name
FDA
EMA
Alymsys, Avastin, Jobevne, Mvasi, Vegzelma, Zirabev
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| alymsys | Biologic Licensing Application | 2022-04-27 |
| avastin | Biologic Licensing Application | 2025-01-06 |
| avzivi | Biologic Licensing Application | 2024-10-09 |
| jobevne | Biologic Licensing Application | 2025-04-01 |
| mvasi | Biologic Licensing Application | 2025-06-23 |
| vegzelma | Biologic Licensing Application | 2025-05-08 |
| zirabev | Biologic Licensing Application | 2025-08-05 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
bevacizumab, Avastin, Genentech, Inc. | |||
| 2027-05-29 | Orphan excl. | ||
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01F: Monoclonal antibodies and antibody drug conjugates
— L01FG: Vegf/vegfr (vascular endothelial growth factor) inhibitors
— L01FG01: Bevacizumab
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01L: Ocular vascular disorder agents
— S01LA: Antineovascularisation agents
— S01LA08: Bevacizumab
Clinical
Clinical Trials
3634 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 6 | 16 | 2 | 1 | 5 | 30 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 3 | 10 | 1 | 2 | — | 16 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 2 | 10 | 1 | 2 | — | 15 |
| Macular edema | D008269 | — | — | 4 | 6 | 2 | 1 | — | 9 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | 1 | 1 | — | 1 | — | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 10 | 41 | 2 | — | 3 | 49 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 5 | 35 | 6 | — | 3 | 48 |
| Neoplasms | D009369 | — | C80 | 10 | 21 | 2 | — | 1 | 32 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 7 | 22 | 1 | — | 1 | 30 |
| Lung neoplasms | D008175 | — | C34.90 | 5 | 22 | 3 | — | 2 | 27 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 6 | 14 | 3 | — | — | 20 |
| Fallopian tube neoplasms | D005185 | — | — | 4 | 14 | 1 | — | 1 | 20 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | 9 | 2 | — | 1 | 12 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 5 | 6 | 1 | — | — | 11 |
| Rectal neoplasms | D012004 | — | — | 2 | 5 | 1 | — | 2 | 9 |
Show 18 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | 5 | 25 | — | — | 1 | 29 |
| Glioma | D005910 | EFO_0000520 | — | 6 | 17 | — | — | 2 | 22 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 4 | 16 | — | — | 1 | 18 |
| Gliosarcoma | D018316 | — | — | — | 14 | — | — | — | 14 |
| Prostatic neoplasms | D011471 | — | C61 | 3 | 9 | — | — | — | 10 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | 10 | — | — | — | 10 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 9 | — | — | — | 9 |
| Esophageal neoplasms | D004938 | — | C15 | — | 9 | — | — | — | 9 |
| Sarcoma | D012509 | — | — | 3 | 5 | — | — | — | 8 |
| Head and neck neoplasms | D006258 | — | — | 2 | 6 | — | — | — | 8 |
Show 79 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic foot | D017719 | EFO_1001459 | — | 1 | — | — | — | — | 1 |
| Foot ulcer | D016523 | — | — | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Radiation injuries | D011832 | — | T66 | 1 | — | — | — | — | 1 |
| Desmoplastic small round cell tumor | D058405 | — | — | 1 | — | — | — | — | 1 |
| Neuromyelitis optica | D009471 | EFO_0004256 | G36.0 | 1 | — | — | — | — | 1 |
| Diffuse intrinsic pontine glioma | D000080443 | — | — | 1 | — | — | — | — | 1 |
| Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | 1 | — | — | — | — | 1 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | 1 | — | — | — | — | 1 |
| Parotid neoplasms | D010307 | EFO_0003873 | C07 | 1 | — | — | — | — | 1 |
Show 5 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Central nervous system neoplasms | D016543 | — | — | — | — | — | — | 1 | 1 |
| Anus neoplasms | D001005 | EFO_0003835 | C21 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bevacizumab |
| INN | bevacizumab |
| Description | Bevacizumab, sold under the brand name Avastin, is a medication used to treat a number of types of cancers and a specific eye disease. For cancer it is given by slow injection into a vein and used for colon cancer, lung cancer, glioblastoma, and renal-cell carcinoma. For age-related macular degeneration it is given by injection into the eye.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >7V5N:A,E|bevacizumab fab light chain
DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
>7V5N:B,F|bevacizumab fab heavy chain
EVQLVESGGGLVQPGGSLRLSCAASGYTFTNYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAY
LQMNSLRAEDTAVYYCAKYPHYYGSSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV
TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT |
Identifiers
| PDB | 6BFT, 7V5N |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201583 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00112 |
| UNII ID | 2S9ZZM9Q9V (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
VEGFA
VEGFA
Organism
Homo sapiens
Gene name
VEGFA
Gene synonyms
NCBI Gene ID
—
Protein name
Vascular endothelial growth factor A
Protein synonyms
Vascular permeability factor
Uniprot ID
Mouse ortholog
—
—
Variants
No data
Financial
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 722 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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126,883 adverse events reported
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