Avastin(bevacizumab)
Abevmy, Alymsys, Avastin, Avzivi, Aybintio, Mvasi, Onbevzi, Oyavas, Vegzelma, Zirabev (bevacizumab) is an antibody pharmaceutical. Bevacizumab was first approved as Lextemy on . It is used to treat colorectal neoplasms, fallopian tube neoplasms, glioblastoma, kidney neoplasms, and non-small-cell lung carcinoma amongst others in the USA. It has been approved in Europe to treat breast neoplasms, colorectal neoplasms, fallopian tube neoplasms, non-small-cell lung carcinoma, and ovarian neoplasms amongst others. The pharmaceutical is active against vascular endothelial growth factor A, long form. In addition, it is known to target Vascular permeability factor.
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Commercial
Trade Name
FDA
EMA
Alymsys, Avastin, Mvasi, Vegzelma, Zirabev
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| alymsys | Biologic Licensing Application | 2022-04-27 |
| avastin | Biologic Licensing Application | 2025-01-06 |
| avzivi | Biologic Licensing Application | 2024-10-09 |
| mvasi | Biologic Licensing Application | 2024-10-31 |
| vegzelma | Biologic Licensing Application | 2023-02-22 |
| zirabev | Biologic Licensing Application | 2025-01-22 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
bevacizumab, Avastin, Genentech, Inc. | |||
| 2027-05-29 | Orphan excl. | ||
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01F: Monoclonal antibodies and antibody drug conjugates
— L01FG: Vegf/vegfr (vascular endothelial growth factor) inhibitors
— L01FG01: Bevacizumab
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01L: Ocular vascular disorder agents
— S01LA: Antineovascularisation agents
— S01LA08: Bevacizumab
Clinical
Clinical Trials
3488 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 116 | 364 | 121 | 16 | 102 | 658 |
| Carcinoma | D002277 | — | C80.0 | 103 | 264 | 57 | 5 | 50 | 423 |
| Non-small-cell lung carcinoma | D002289 | — | — | 59 | 191 | 63 | 2 | 32 | 324 |
| Lung neoplasms | D008175 | — | C34.90 | 49 | 183 | 50 | 2 | 32 | 295 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 48 | 179 | 38 | 6 | 37 | 288 |
| Neoplasms | D009369 | — | C80 | 149 | 120 | 21 | 6 | 24 | 283 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 32 | 70 | 48 | 23 | 80 | 226 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 49 | 126 | 40 | 2 | 26 | 224 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 36 | 132 | 24 | 4 | 39 | 212 |
| Macular edema | D008269 | — | — | 16 | 52 | 58 | 42 | 66 | 211 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | 57 | 132 | 14 | — | 26 | 199 |
| Adenocarcinoma | D000230 | — | — | 35 | 84 | 26 | — | 8 | 135 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 26 | 64 | 8 | — | 11 | 94 |
| Glioma | D005910 | EFO_0000520 | — | 28 | 63 | 5 | — | 12 | 92 |
| Rectal neoplasms | D012004 | — | — | 19 | 59 | 9 | — | 8 | 87 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 28 | 41 | 3 | — | 2 | 60 |
| Uterine cervical neoplasms | D002583 | — | — | 16 | 35 | 13 | — | 5 | 59 |
| Melanoma | D008545 | — | — | 16 | 40 | 1 | — | 3 | 51 |
| Gliosarcoma | D018316 | — | — | 10 | 35 | 1 | — | 1 | 42 |
| Squamous cell carcinoma | D002294 | — | — | 11 | 30 | 4 | — | 1 | 37 |
Show 137 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 7 | 22 | — | — | — | 26 |
| Healthy volunteers/patients | — | — | — | 23 | 2 | — | — | 1 | 26 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 4 | — | — | 13 | 17 |
| Leukemia | D007938 | — | C95 | 7 | 11 | — | — | — | 16 |
| Cholangiocarcinoma | D018281 | — | C22.1 | 7 | 12 | — | — | — | 16 |
| Central nervous system neoplasms | D016543 | — | — | 5 | 10 | — | — | 2 | 16 |
| Nervous system neoplasms | D009423 | — | — | 3 | 10 | — | — | 3 | 15 |
| Syndrome | D013577 | — | — | 8 | 9 | — | — | — | 14 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 6 | 12 | — | — | — | 14 |
| Multiple myeloma | D009101 | — | C90.0 | 3 | 9 | — | — | 1 | 12 |
Show 245 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Von hippel-lindau disease | D006623 | — | Q85.83 | 3 | — | — | — | 1 | 4 |
| Degenerative myopia | D047728 | — | H44.2 | 1 | — | — | — | 2 | 3 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 2 | — | — | — | — | 2 |
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 2 | — | — | — | — | 2 |
| Chondrosarcoma | D002813 | — | — | 2 | — | — | — | — | 2 |
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
| Hypoxia | D000860 | — | R09.02 | 1 | — | — | — | 1 | 2 |
| Pharyngeal neoplasms | D010610 | — | C14.0 | 2 | — | — | — | — | 2 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 2 | — | — | — | — | 2 |
| Hemangioblastoma | D018325 | — | — | 1 | — | — | — | 1 | 2 |
Show 49 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 5 | 5 |
| Choroid diseases | D015862 | — | H31.9 | — | — | — | — | 3 | 3 |
| Intraocular pressure | D007429 | — | — | — | — | — | — | 2 | 2 |
| Vitrectomy | D014821 | — | — | — | — | — | — | 2 | 2 |
| Diabetes complications | D048909 | — | — | — | — | — | — | 2 | 2 |
| Sentinel lymph node biopsy | D021701 | — | — | — | — | — | — | 2 | 2 |
| Fluorescence | D005453 | — | — | — | — | — | — | 2 | 2 |
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | — | — | — | 2 | 2 |
| Dry eye syndromes | D015352 | — | H04.12 | — | — | — | — | 2 | 2 |
| Wound infection | D014946 | — | — | — | — | — | — | 1 | 1 |
Show 53 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bevacizumab |
| INN | bevacizumab |
| Description | Bevacizumab, sold under the brand name Avastin, is a medication used to treat a number of types of cancers and a specific eye disease. For cancer it is given by slow injection into a vein and used for colon cancer, lung cancer, glioblastoma, and renal-cell carcinoma. For age-related macular degeneration it is given by injection into the eye.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >7V5N:A,E|bevacizumab fab light chain
DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
>7V5N:B,F|bevacizumab fab heavy chain
EVQLVESGGGLVQPGGSLRLSCAASGYTFTNYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAY
LQMNSLRAEDTAVYYCAKYPHYYGSSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV
TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT |
Identifiers
| PDB | 6BFT, 7V5N |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201583 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00112 |
| UNII ID | 2S9ZZM9Q9V (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
VEGFA
VEGFA
Organism
Homo sapiens
Gene name
VEGFA
Gene synonyms
NCBI Gene ID
—
Protein name
Vascular endothelial growth factor A
Protein synonyms
Vascular permeability factor
Uniprot ID
Mouse ortholog
—
—
Variants
No data
Financial
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 95,267 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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122,933 adverse events reported
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