Brand Name | Status | Last Update |
---|---|---|
alymsys | Biologic Licensing Application | 2022-04-27 |
avastin | Biologic Licensing Application | 2025-01-06 |
avzivi | Biologic Licensing Application | 2024-10-09 |
jobevne | Biologic Licensing Application | 2025-04-01 |
mvasi | Biologic Licensing Application | 2025-06-23 |
vegzelma | Biologic Licensing Application | 2025-05-08 |
zirabev | Biologic Licensing Application | 2025-01-22 |
Expiration | Code | ||
---|---|---|---|
bevacizumab, Avastin, Genentech, Inc. | |||
2027-05-29 | Orphan excl. |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Colorectal neoplasms | D015179 | — | — | 120 | 382 | 124 | 17 | 104 | 684 |
Carcinoma | D002277 | — | C80.0 | 103 | 274 | 58 | 5 | 54 | 438 |
Non-small-cell lung carcinoma | D002289 | — | — | 59 | 196 | 63 | 2 | 33 | 330 |
Lung neoplasms | D008175 | — | C34.90 | 50 | 186 | 51 | 2 | 33 | 301 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | 49 | 181 | 38 | 6 | 37 | 291 |
Neoplasms | D009369 | — | C80 | 154 | 124 | 21 | 6 | 24 | 289 |
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 51 | 133 | 41 | 2 | 26 | 233 |
Macular degeneration | D008268 | EFO_0001365 | H35.30 | 32 | 70 | 49 | 23 | 80 | 227 |
Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 36 | 138 | 24 | 5 | 40 | 220 |
Hepatocellular carcinoma | D006528 | — | C22.0 | 31 | 131 | 22 | 4 | 47 | 215 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Glioblastoma | D005909 | EFO_0000515 | — | 57 | 132 | 14 | — | 27 | 200 |
Adenocarcinoma | D000230 | — | — | 35 | 85 | 28 | — | 8 | 138 |
Brain neoplasms | D001932 | EFO_0003833 | C71 | 26 | 64 | 9 | — | 11 | 95 |
Glioma | D005910 | EFO_0000520 | — | 28 | 63 | 5 | — | 12 | 92 |
Rectal neoplasms | D012004 | — | — | 19 | 63 | 8 | — | 8 | 90 |
Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 29 | 41 | 3 | — | 2 | 61 |
Uterine cervical neoplasms | D002583 | — | — | 17 | 37 | 13 | — | 5 | 61 |
Gliosarcoma | D018316 | — | — | 10 | 35 | 1 | — | 1 | 42 |
Squamous cell carcinoma | D002294 | — | — | 12 | 31 | 4 | — | 1 | 39 |
Squamous cell carcinoma of head and neck | D000077195 | — | — | 13 | 25 | 4 | — | — | 32 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Endometrial neoplasms | D016889 | EFO_0004230 | — | 8 | 24 | — | — | — | 28 |
Healthy volunteers/patients | — | — | — | 23 | 2 | — | — | 1 | 26 |
Cholangiocarcinoma | D018281 | — | C22.1 | 8 | 12 | — | — | — | 17 |
Hypertension | D006973 | EFO_0000537 | I10 | 1 | 4 | — | — | 13 | 17 |
Leukemia | D007938 | — | C95 | 7 | 11 | — | — | — | 16 |
Central nervous system neoplasms | D016543 | — | — | 5 | 10 | — | — | 2 | 16 |
Nervous system neoplasms | D009423 | — | — | 3 | 10 | — | — | 3 | 15 |
Syndrome | D013577 | — | — | 8 | 9 | — | — | — | 14 |
Oligodendroglioma | D009837 | EFO_0000631 | — | 6 | 12 | — | — | — | 14 |
Multiple myeloma | D009101 | — | C90.0 | 3 | 9 | — | — | 1 | 12 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Von hippel-lindau disease | D006623 | — | Q85.83 | 3 | — | — | — | 1 | 4 |
Degenerative myopia | D047728 | — | H44.2 | 1 | — | — | — | 2 | 3 |
Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 2 | — | — | — | — | 2 |
Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 2 | — | — | — | — | 2 |
Chondrosarcoma | D002813 | — | — | 2 | — | — | — | — | 2 |
Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
Hypoxia | D000860 | — | R09.02 | 1 | — | — | — | 1 | 2 |
Hemangioma | D006391 | — | D18.0 | 2 | — | — | — | — | 2 |
Pharyngeal neoplasms | D010610 | — | C14.0 | 2 | — | — | — | — | 2 |
B-cell lymphoma marginal zone | D018442 | — | C88.4 | 2 | — | — | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 5 | 5 |
Choroid diseases | D015862 | — | H31.9 | — | — | — | — | 3 | 3 |
Intraocular pressure | D007429 | — | — | — | — | — | — | 2 | 2 |
Vitrectomy | D014821 | — | — | — | — | — | — | 2 | 2 |
Diabetes complications | D048909 | — | — | — | — | — | — | 2 | 2 |
Sentinel lymph node biopsy | D021701 | — | — | — | — | — | — | 2 | 2 |
Fluorescence | D005453 | — | — | — | — | — | — | 2 | 2 |
Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | — | — | — | 2 | 2 |
Dry eye syndromes | D015352 | — | H04.12 | — | — | — | — | 2 | 2 |
Wound infection | D014946 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Bevacizumab |
INN | bevacizumab |
Description | Bevacizumab, sold under the brand name Avastin, is a medication used to treat a number of types of cancers and a specific eye disease. For cancer it is given by slow injection into a vein and used for colon cancer, lung cancer, glioblastoma, and renal-cell carcinoma. For age-related macular degeneration it is given by injection into the eye.
|
Classification | Antibody |
Drug class | monoclonal antibodies |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | >7V5N:A,E|bevacizumab fab light chain
DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
>7V5N:B,F|bevacizumab fab heavy chain
EVQLVESGGGLVQPGGSLRLSCAASGYTFTNYGMNWVRQAPGKGLEWVGWINTYTGEPTYAADFKRRFTFSLDTSKSTAY
LQMNSLRAEDTAVYYCAKYPHYYGSSHWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV
TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT |
PDB | 6BFT, 7V5N |
CAS-ID | — |
RxCUI | — |
ChEMBL ID | CHEMBL1201583 |
ChEBI ID | — |
PubChem CID | — |
DrugBank | DB00112 |
UNII ID | 2S9ZZM9Q9V (ChemIDplus, GSRS) |