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Drug ReportsBenztropine
Benztropine
Benztropine (benztropine) is a small molecule pharmaceutical. Benztropine was first approved as Cogentin on 1982-01-01. It is used to treat drug-induced abnormalities and parkinson disease in the USA. It is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M1, sodium-dependent dopamine transporter, and sodium-dependent neutral amino acid transporter B(0)AT1.
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Target
Variants
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Events Timeline
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YTD
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2Y
5Y
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
hereditary congenital and neonatal diseases and abnormalitiesD009358
Trade Name
FDA
EMA
Benztropine (discontinued: Benztropine, Cogentin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Benztropine mesylate
Tradename
Company
Number
Date
Products
COGENTINEpic PharmaN-012015 DISCN1982-01-01
1 products, RLD
COGENTINMerck & CoN-009193 DISCN1982-01-01
3 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
benztropineANDA2018-12-19
benztropine mesylateANDA2024-11-06
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
parkinson diseaseEFO_0002508D010300G20
drug-induced abnormalities—D000014—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N04: Anti-parkinson drugs
— N04A: Anticholinergic agents
— N04AC: Ethers of tropine or tropine derivatives, anticholinergic
— N04AC01: Benzatropine
HCPCS
Code
Description
J0515
Injection, benztropine mesylate, per 1 mg
Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20——1315
Psychotic disordersD011618—F20.81——1214
Bipolar disorderD001714EFO_0000289F30.9———2—2
EmergenciesD004630—————1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Mental disordersD001523EFO_0000677F91.9——1——1
Schizophrenia spectrum and other psychotic disordersD019967————1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Back painD001416HP_0003418M54—2———2
SciaticaD012585HP_0011868M54.3—1———1
InfectionsD007239EFO_0000544——1———1
Hiv infectionsD015658EFO_0000764B20—1———1
Peripheral nervous system diseasesD010523HP_0009830G64—1———1
Acquired immunodeficiency syndromeD000163EFO_0000765B20—1———1
Communicable diseasesD003141———1———1
Nervous system diseasesD009422—G00-G99—1———1
Temporomandibular joint disordersD013705—M26.6—1———1
Joint diseasesD007592HP_0003040M12.9—1———1
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Therapeutic equivalencyD013810——2————2
MalnutritionD044342EFO_0008572E40-E461————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Paranoid schizophreniaD012563—F20.0————11
Wounds and injuriesD014947—T14.8————11
PainD010146EFO_0003843R52————11
Spinal cord injuriesD013119EFO_1001919—————11
NeuralgiaD009437EFO_0009430—————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBenztropine
INNbenzatropine
Description
Benzatropine is tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to reduce parkinsonism and akathisia side effects of antipsychotic treatments. It has a role as an antiparkinson drug, a parasympatholytic, an antidyskinesia agent, a muscarinic antagonist and a oneirogen.
Classification
Small molecule
Drug classatropine derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccccc1)C2
Identifiers
PDB—
CAS-ID86-13-5
RxCUI—
ChEMBL IDCHEMBL1201203
ChEBI ID3048
PubChem CID1201549
DrugBankDB00245
UNII ID1NHL2J4X8K (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CHRM2
CHRM2
CHRM1
CHRM1
SLC6A3
SLC6A3
SLC6A19
SLC6A19
Organism
Homo sapiens
Gene name
CHRM2
Gene synonyms
NCBI Gene ID
1129
Protein name
muscarinic acetylcholine receptor M2
Protein synonyms
7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor
Uniprot ID
Q9P1X9
Mouse ortholog
Chrm2 (243764)
muscarinic acetylcholine receptor M2 (Q9ERZ4)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Benztropine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,783 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,609 adverse events reported
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