Benztropine
Benztropine (benztropine) is a small molecule pharmaceutical. Benztropine was first approved as Cogentin on 1982-01-01. It is used to treat drug-induced abnormalities and parkinson disease in the USA. It is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M1, sodium-dependent dopamine transporter, and sodium-dependent neutral amino acid transporter B(0)AT1.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Benztropine (discontinued: Benztropine, Cogentin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Benztropine mesylate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COGENTIN | Epic Pharma | N-012015 DISCN | 1982-01-01 | 1 products, RLD |
| COGENTIN | Merck & Co | N-009193 DISCN | 1982-01-01 | 3 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| benztropine | ANDA | 2018-12-19 |
| benztropine mesylate | ANDA | 2025-08-07 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| parkinson disease | EFO_0002508 | D010300 | G20 |
| drug-induced abnormalities | — | D000014 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J0515 | Injection, benztropine mesylate, per 1 mg |
Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | 3 | 2 | 6 |
| Psychotic disorders | D011618 | — | F20.81 | — | — | 1 | 2 | 2 | 5 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | 2 | 1 | 3 |
| Emergencies | D004630 | — | — | — | — | — | 1 | — | 1 |
| Medically unexplained symptoms | D000071896 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | — | 1 | — | 1 | 2 |
| Schizophrenia spectrum and other psychotic disorders | D019967 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Back pain | D001416 | — | M54 | — | 2 | — | — | — | 2 |
| Sciatica | D012585 | — | M54.3 | — | 1 | — | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | — | — | 1 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | — | — | — | 1 |
| Peripheral nervous system diseases | D010523 | — | G64 | — | 1 | — | — | — | 1 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | 1 | — | — | — | 1 |
| Communicable diseases | D003141 | — | — | — | 1 | — | — | — | 1 |
| Nervous system diseases | D009422 | — | G00-G99 | — | 1 | — | — | — | 1 |
| Temporomandibular joint disorders | D013705 | — | M26.6 | — | 1 | — | — | — | 1 |
| Joint diseases | D007592 | — | M12.9 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Therapeutic equivalency | D013810 | — | — | 2 | — | — | — | — | 2 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Paranoid schizophrenia | D012563 | — | F20.0 | — | — | — | — | 1 | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 1 | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | — | 1 | 1 |
| Neuralgia | D009437 | EFO_0009430 | — | — | — | — | — | 1 | 1 |
| Problem behavior | D000066553 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Benztropine |
| INN | benzatropine |
| Description | Benzatropine is tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to reduce parkinsonism and akathisia side effects of antipsychotic treatments. It has a role as an antiparkinson drug, a parasympatholytic, an antidyskinesia agent, a muscarinic antagonist and a oneirogen. |
| Classification | Small molecule |
| Drug class | atropine derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccccc1)C2 |
Identifiers
| PDB | — |
| CAS-ID | 86-13-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201203 |
| ChEBI ID | 3048 |
| PubChem CID | 1201549 |
| DrugBank | DB00245 |
| UNII ID | 1NHL2J4X8K (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CHRM2
CHRM2
CHRM1
CHRM1
SLC6A3
SLC6A3
SLC6A19
SLC6A19
Variants
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Financial
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Estimated US medical usage
Benztropine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,013 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,891 adverse events reported
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