Benzonatate
Benzonatate, Tessalon (benzonatate) is a small molecule pharmaceutical. Benzonatate was first approved as Tessalon on 1982-01-01. It is used to treat cough and hiccup in the USA.
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Commercial
Therapeutic Areas
Trade Name
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Benzonatate, Tessalon (discontinued: Benzonatate, Tessalon)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| benzonatate | ANDA | 2024-10-24 |
Agency Specific
FDA
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HCPCS
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Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cough | D003371 | HP_0012735 | R05 | 2 | — | 1 | — | — | 3 |
Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Benzonatate |
| INN | benzonatate |
| Description | Benzonatate is the ester obtained by formal condensation of 4-butylaminobenzoic acid with nonaethylene glycol monomethyl ether. Structurally related to procaine and benzocaine, it has an anaesthetic effect on the stretch sensors in the lungs, and is used as a non-narcotic cough suppressant. It has a role as an antitussive and an anaesthetic. It is a benzoate ester, a substituted aniline and a secondary amino compound. It is functionally related to a 4-(butylamino)benzoic acid and a nonaethylene glycol monomethyl ether. |
| Classification | Small molecule |
| Drug class | Antitussives; Local anesthetics; Sodium channel blockers |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCNc1ccc(C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 104-31-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1374379 |
| ChEBI ID | 3032 |
| PubChem CID | 7699 |
| DrugBank | DB00868 |
| UNII ID | 5P4DHS6ENR (ChemIDplus, GSRS) |
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Estimated US medical usage
Benzonatate
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Additional graphs summarizing 256 documents
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Safety
Black-box Warning
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Adverse Events
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1,380 adverse events reported
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