Benzodiazepine
Benzodiazepine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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ATC Codes
N: Nervous system drugs
— N03: Antiepileptics
— N03A: Antiepileptics
— N03AE: Benzodiazepine derivative antiepileptics
— N05: Psycholeptics
— N05B: Anxiolytics
— N05BA: Benzodiazepine derivative anxiolytics
— N05C: Hypnotics and sedatives
— N05CD: Benzodiazepine derivative hypnotics and sedatives
— N05CF: Benzodiazepine related hypnotics and sedatives
HCPCS
Code | Description |
|---|---|
| G0033 | Two or more benzodiazepine prescriptions ordered for patients who had a diagnosis of seizure disorders, rapid eye movement sleep behavior disorder, benzodiazepine withdrawal, ethanol withdrawal, or severe generalized anxiety disorder on or between january 1 of the year prior to the measurement period and the ipsd for benzodiazepines |
Clinical
Clinical Trials
1998 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 229 | 4 | 3 | 8 | 15 | 258 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 18 | 26 | 46 | 68 | 38 | 191 |
| Psychotic disorders | D011618 | — | F20.81 | 4 | 5 | 14 | 35 | 14 | 71 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 4 | 4 | 20 | 35 | 9 | 71 |
| Depression | D003863 | — | F33.9 | 10 | 16 | 15 | 19 | 16 | 68 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 10 | 10 | 5 | 26 | 17 | 67 |
| Neoplasms | D009369 | — | C80 | 38 | 10 | 12 | 3 | 7 | 64 |
| Vomiting | D014839 | — | R11.1 | 3 | 18 | 26 | 6 | 9 | 58 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 12 | 13 | 12 | 17 | 10 | 58 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | 8 | 6 | 3 | 16 | 24 | 54 |
Show 292 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic pain | D059350 | — | — | 1 | — | 1 | — | 6 | 8 |
| Covid-19 | D000086382 | — | U07.1 | 3 | — | 1 | — | 3 | 7 |
| Acute pain | D059787 | — | R52 | — | 2 | 2 | — | 4 | 7 |
| Personality disorders | D010554 | — | F60.6 | — | 1 | 2 | — | 4 | 7 |
| Renal insufficiency | D051437 | — | N19 | 3 | — | 3 | — | — | 6 |
| Sclerosis | D012598 | — | — | 3 | 3 | 2 | — | — | 6 |
| Low back pain | D017116 | — | M54.5 | 1 | 2 | 2 | — | 2 | 6 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | 1 | — | 3 | — | 2 | 6 |
| Poisoning | D011041 | EFO_0008546 | T65.91 | — | 2 | 1 | — | 3 | 6 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | 1 | 2 | — | 3 | 6 |
Show 81 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug interactions | D004347 | — | — | 23 | 1 | — | — | 4 | 27 |
| Cocaine-related disorders | D019970 | — | F14 | 3 | 3 | — | — | 2 | 7 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 5 | 1 | — | — | — | 6 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 2 | 3 | — | — | 1 | 5 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 2 | — | — | 3 | 5 |
| Drug overdose | D062787 | — | — | 1 | 1 | — | — | 3 | 5 |
| Carcinoma | D002277 | — | C80.0 | 1 | 2 | — | — | 1 | 4 |
| Colorectal neoplasms | D015179 | — | — | 1 | 2 | — | — | 1 | 4 |
| Leukemia | D007938 | — | C95 | 4 | 3 | — | — | — | 4 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 4 | 3 | — | — | — | 4 |
Show 70 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriasis | D011565 | EFO_0000676 | L40 | 8 | — | — | — | — | 8 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 6 | — | — | — | 2 | 8 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 6 | — | — | — | 2 | 8 |
| Infections | D007239 | EFO_0000544 | — | 4 | — | — | — | 3 | 7 |
| Heart failure | D006333 | EFO_0003144 | I50 | 2 | — | — | — | 4 | 6 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 5 | — | — | — | — | 5 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 3 | — | — | — | 1 | 4 |
| Food-drug interactions | D018565 | — | — | 4 | — | — | — | — | 4 |
| Dermatitis | D003872 | — | L30.9 | 4 | — | — | — | — | 4 |
| Respiratory syncytial virus infections | D018357 | EFO_1001413 | — | 4 | — | — | — | — | 4 |
Show 117 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Aging | D000375 | GO_0007568 | R41.81 | — | — | — | — | 5 | 5 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 4 | 4 |
| Hypoxia | D000860 | — | R09.02 | — | — | — | — | 4 | 4 |
| Deprescriptions | D000069340 | — | — | — | — | — | — | 4 | 4 |
| Narcotic-related disorders | D000079524 | — | — | — | — | — | — | 3 | 3 |
| Tachycardia | D013610 | — | R00.0 | — | — | — | — | 3 | 3 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 3 | 3 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 2 | 2 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 2 | 2 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Benzodiazepine |
| INN | — |
| Description | Benzodiazepines (BZD, BDZ, BZs), colloquially called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed to treat conditions such as anxiety disorders, insomnia, and seizures. The first benzodiazepine, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955 and was made available in 1960 by Hoffmann–La Roche, who soon followed with diazepam (Valium) in 1963. By 1977, benzodiazepines were the most prescribed medications globally; the introduction of selective serotonin reuptake inhibitors (SSRIs), among other factors, decreased rates of prescription, but they remain frequently used worldwide.
|
| Classification | Small molecule |
| Drug class | tricyclic compounds |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C1=Cc2ccccc2NN=C1 |
Identifiers
| PDB | — |
| CAS-ID | 12794-10-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297264 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | — |
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Safety
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Adverse Events
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3,579 adverse events reported
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