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Drug ReportsBenzodiazepine
Benzodiazepine
Benzodiazepine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Events Timeline
5D
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YTD
1Y
2Y
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Events
FDA approval date
EMA approval date
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Study first post date
Last update post date
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Trade Name
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Agency Specific
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ATC Codes
N: Nervous system drugs
N03: Antiepileptics
N03A: Antiepileptics
N03AE: Benzodiazepine derivative antiepileptics
N05: Psycholeptics
N05B: Anxiolytics
N05BA: Benzodiazepine derivative anxiolytics
N05C: Hypnotics and sedatives
N05CD: Benzodiazepine derivative hypnotics and sedatives
N05CF: Benzodiazepine related hypnotics and sedatives
HCPCS
Code
Description
G0033
Two or more benzodiazepine prescriptions ordered for patients who had a diagnosis of seizure disorders, rapid eye movement sleep behavior disorder, benzodiazepine withdrawal, ethanol withdrawal, or severe generalized anxiety disorder on or between january 1 of the year prior to the measurement period and the ipsd for benzodiazepines
Clinical
Clinical Trials
340 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Substance-related disordersD019966EFO_0003890F133121823
DepressionD003863F33.94251019
Anxiety disordersD001008EFO_0006788F41.1127818
Sleep initiation and maintenance disordersD007319F51.011141016
Substance withdrawal syndromeD013375EFO_00058005914
AnxietyD001007EFO_0005230F41.1114914
Depressive disorderD003866EFO_1002014F32.A424614
DeliriumD003693R41.023813
Drug-related side effects and adverse reactionsD064420T88.712912
Opioid-related disordersD009293EFO_0005611F11311711
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EpilepsyD004827EFO_0000474G40.912338
AnesthesiaD0007583148
SeizuresD012640G40.42135
Neonatal abstinence syndromeD009357EFO_0005799P96.111124
Artificial respirationD012121123
Low back painD017116M54.52113
HypotensionD007022EFO_0005251I95123
Drug resistant epilepsyD0000692791112
Critical illnessD01663822
Covid-19D000086382U07.1112
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients132520
Drug overdoseD062787145
PoisoningD011041EFO_0008546T65.91235
Brain diseasesD001927G93.401123
Hiv infectionsD015658EFO_0000764B20123
Acute painD059787R52112
EmergenciesD004630112
Parkinson diseaseD010300EFO_0002508G20112
SarcomaD01250911
Alveolar soft part sarcomaD01823411
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Emergence deliriumD000071257145
Drug interactionsD004347213
Alzheimer diseaseD000544EFO_0000249F03123
Myocardial infarctionD009203EFO_0000612I21112
InfarctionD007238EFO_0009463112
SclerosisD01259822
NeurocysticercosisD02001922
CysticercosisD003551EFO_0007231B6922
TaeniasisD013622EFO_1001433B6822
Prostatic neoplasmsD011471C6111
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic painD05935066
AgingD000375GO_0007568R41.8155
DeprescriptionsD00006934044
Postoperative painD010149G89.1833
Personality disordersD010554F60.633
Narcotic-related disordersD00007952422
HypoxiaD000860R09.0222
Heart failureD006333EFO_0003144I5022
Chronic renal insufficiencyD051436N1822
Kidney diseasesD007674EFO_0003086N0822
Show 121 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBenzodiazepine
INN
Description
Benzodiazepines (BZD, BDZ, BZs), colloquially called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed to treat conditions such as anxiety disorders, insomnia, and seizures. The first benzodiazepine, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955 and was made available in 1960 by Hoffmann–La Roche, who soon followed with diazepam (Valium) in 1963. By 1977, benzodiazepines were the most prescribed medications globally; the introduction of selective serotonin reuptake inhibitors (SSRIs), among other factors, decreased rates of prescription, but they remain frequently used worldwide.
Classification
Small molecule
Drug classtricyclic compounds
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Structure (InChI/SMILES or Protein Sequence)
C1=Cc2ccccc2NN=C1
Identifiers
PDB
CAS-ID12794-10-4
RxCUI
ChEMBL IDCHEMBL4297264
ChEBI ID
PubChem CID
DrugBank
UNII ID
Target
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 51,183 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,568 adverse events reported
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