Benzodiazepine
Benzodiazepine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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ATC Codes
N: Nervous system drugs
— N03: Antiepileptics
— N03A: Antiepileptics
— N03AE: Benzodiazepine derivative antiepileptics
— N05: Psycholeptics
— N05B: Anxiolytics
— N05BA: Benzodiazepine derivative anxiolytics
— N05C: Hypnotics and sedatives
— N05CD: Benzodiazepine derivative hypnotics and sedatives
— N05CF: Benzodiazepine related hypnotics and sedatives
HCPCS
Code | Description |
|---|---|
| G0033 | Two or more benzodiazepine prescriptions ordered for patients who had a diagnosis of seizure disorders, rapid eye movement sleep behavior disorder, benzodiazepine withdrawal, ethanol withdrawal, or severe generalized anxiety disorder on or between january 1 of the year prior to the measurement period and the ipsd for benzodiazepines |
Clinical
Clinical Trials
316 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 3 | 1 | 2 | 14 | 19 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | 1 | 1 | — | 4 | 8 | 13 |
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | 1 | — | 1 | 3 | 7 | 12 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 2 | 5 | 5 | 12 |
| Delirium | D003693 | — | R41.0 | 2 | — | — | 2 | 7 | 11 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | 1 | 5 | 4 | 10 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 2 | — | 1 | 6 | 9 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | 1 | 2 | 5 | 8 |
| Psychotic disorders | D011618 | — | F20.81 | — | — | — | 5 | 2 | 7 |
| Depression | D003863 | — | F33.9 | — | 1 | — | 2 | 3 | 6 |
Show 35 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Epilepsy | D004827 | EFO_0000474 | G40.9 | 1 | 2 | 3 | — | 3 | 8 |
| Anesthesia | D000758 | — | — | 2 | — | 1 | — | 3 | 6 |
| Neonatal abstinence syndrome | D009357 | EFO_0005799 | P96.1 | 1 | 1 | 1 | — | 1 | 3 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | 2 | 1 | — | 1 | 3 |
| Artificial respiration | D012121 | — | — | — | — | 1 | — | 1 | 2 |
| Critical illness | D016638 | — | — | — | — | 2 | — | — | 2 |
| Covid-19 | D000086382 | — | U07.1 | — | — | 1 | — | 1 | 2 |
| Conscious sedation | D016292 | — | — | — | — | 1 | — | 1 | 2 |
| Hip fractures | D006620 | EFO_0003964 | S72.00 | — | — | 1 | — | — | 1 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | 1 | 1 | — | — | 1 |
Show 7 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 12 | 2 | — | — | 5 | 19 |
| Neoplasms | D009369 | — | C80 | 2 | 2 | — | — | 1 | 3 |
| Acute pain | D059787 | — | R52 | — | 1 | — | — | 1 | 2 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 1 | — | — | — | 1 |
| Liposarcoma | D008080 | — | — | 1 | 1 | — | — | — | 1 |
| Adenocarcinoma of lung | D000077192 | — | — | 1 | 1 | — | — | — | 1 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | — | — | — | 1 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | 1 | 1 | — | — | — | 1 |
| Hepatic encephalopathy | D006501 | — | K72.91 | 1 | 1 | — | — | — | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | — | — | — | 1 |
Show 7 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug interactions | D004347 | — | — | 2 | — | — | — | — | 2 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | — | — | — | 1 | 2 |
| Neurocysticercosis | D020019 | — | — | 2 | — | — | — | — | 2 |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | 1 | — | — | — | — | 1 |
| Amnesia | D000647 | EFO_1001454 | F44.0 | 1 | — | — | — | — | 1 |
| Dystonic disorders | D020821 | — | G24 | 1 | — | — | — | — | 1 |
| Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | 1 | — | — | — | — | 1 |
| Neuralgia | D009437 | EFO_0009430 | — | 1 | — | — | — | — | 1 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | 1 | — | — | — | — | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | — | — | — | 1 |
Show 1 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic pain | D059350 | HP_0012532 | — | — | — | — | — | 7 | 7 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 4 | 4 |
| Aging | D000375 | GO_0007568 | R41.81 | — | — | — | — | 4 | 4 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | — | 3 | 3 |
| Narcotic-related disorders | D000079524 | — | — | — | — | — | — | 2 | 2 |
| Hypoxia | D000860 | HP_0012418 | R09.02 | — | — | — | — | 2 | 2 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | — | — | 2 | 2 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | — | 2 | 2 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 2 | 2 |
| Headache | D006261 | HP_0002315 | R51 | — | — | — | — | 2 | 2 |
Show 83 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Benzodiazepine |
| INN | — |
| Description | Benzodiazepines (BZD, BDZ, BZs), colloquially called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed to treat conditions such as anxiety disorders, insomnia, and seizures. The first benzodiazepine, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955 and was made available in 1960 by Hoffmann–La Roche, who soon followed with diazepam (Valium) in 1963. By 1977, benzodiazepines were the most prescribed medications globally; the introduction of selective serotonin reuptake inhibitors (SSRIs), among other factors, decreased rates of prescription, but they remain frequently used worldwide.
|
| Classification | Small molecule |
| Drug class | tricyclic compounds |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C1=Cc2ccccc2NN=C1 |
Identifiers
| PDB | — |
| CAS-ID | 12794-10-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297264 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | — |
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Safety
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Adverse Events
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3,144 adverse events reported
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