Benzhydrocodone
Apadaz (benzhydrocodone) is a small molecule pharmaceutical. Benzhydrocodone was first approved as Apadaz on 2018-02-23. It is used to treat pain in the USA.
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Acetaminophen
+
Benzhydrocodone hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| APADAZ | Zevra Therapeutics | N-208653 DISCN | 2018-02-23 | 3 products, RLD |
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Brand Name | Status | Last Update |
|---|---|---|
| apadaz | New Drug Application | 2025-01-07 |
| benzhydrocodone and acetaminophen | NDA authorized generic | 2021-05-19 |
Indications
FDA
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Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pain | EFO_0003843 | D010146 | R52 |
| fever | HP_0001945 | D005334 | R50.9 |
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Drug
General
| Drug common name | Benzhydrocodone |
| INN | benzhydrocodone |
| Description | Benzhydrocodone (INN) (contracted from benzoate-hydrocodone) is an opioid prodrug of the morphinan class. Its chemical structure consists of hydrocodone coupled with benzoic acid. Benzhydrocodone itself is inactive and acts as a prodrug to hydrocodone upon cleavage of the benzoate portion of the molecule.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc2c3c1O[C@H]1C(OC(=O)c4ccccc4)=CC[C@@H]4[C@@H](C2)N(C)CC[C@@]341 |
Identifiers
| PDB | — |
| CAS-ID | 1259440-61-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3137321 |
| ChEBI ID | — |
| PubChem CID | 49836084 |
| DrugBank | DB15465 |
| UNII ID | 75MS0AAZ9I (ChemIDplus, GSRS) |
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Safety
Black-box Warning
Black-box warning for: Apadaz, Benzhydrocodone and acetaminophen
Adverse Events
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