Bendroflumethiazide
Corzide, Naturetin (bendroflumethiazide) is a small molecule pharmaceutical. Bendroflumethiazide was first approved as Naturetin-2.5 on 1982-01-01. It is used to treat edema, heart failure, hypertension, and nephrotic syndrome in the USA.
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Drug Products
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Abbreviated New Drug Application (ANDA)
Bendroflumethiazide
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Nadolol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CORZIDE | King Pharmaceuticals | N-018647 DISCN | 1983-05-25 | 2 products, RLD |
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Bendroflumethiazide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NATURETIN-2.5 | Bristol Myers Squibb | N-012164 DISCN | 1982-01-01 | 1 products |
| NATURETIN-5 | Bristol Myers Squibb | N-012164 DISCN | 1982-01-01 | 1 products |
| NATURETIN-10 | Bristol Myers Squibb | N-012164 DISCN | 1982-01-01 | 1 products |
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| nadolol and bendroflumethiazide | ANDA | 2016-04-15 |
Agency Specific
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ATC Codes
C: Cardiovascular system drugs
— C03: Diuretics
— C03A: Low-ceiling diuretics, thiazides
— C03AA: Thiazides, plain
— C03AA01: Bendroflumethiazide
— C03AB: Thiazides and potassium in combination
— C03AB01: Bendroflumethiazide and potassium
— C03E: Diuretics and potassium-sparing agents in combination
— C03EA: Low-ceiling diuretics and potassium-sparing agents
— C03EA13: Bendroflumethiazide and potassium-sparing agents
HCPCS
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Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | 2 | 3 | 5 |
| Covid-19 | D000086382 | — | — | — | — | — | 1 | 1 | 2 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Heart failure | D006333 | HP_0001635 | I50 | 2 | — | — | — | — | 2 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Left ventricular hypertrophy | D017379 | EFO_0003896 | — | — | — | — | — | 1 | 1 |
| Hypertrophy | D006984 | EFO_0002460 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bendroflumethiazide |
| INN | bendroflumethiazide |
| Description | Bendroflumethiazide is a sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a sulfonamide. |
| Classification | Small molecule |
| Drug class | diuretics (thiazide derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NS(=O)(=O)c1cc2c(cc1C(F)(F)F)NC(Cc1ccccc1)NS2(=O)=O |
Identifiers
| PDB | — |
| CAS-ID | 73-48-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1684 |
| ChEBI ID | 3013 |
| PubChem CID | 2315 |
| DrugBank | DB00436 |
| UNII ID | 5Q52X6ICJI (ChemIDplus, GSRS) |
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Estimated US medical usage
Bendroflumethiazide
+
Nadolol
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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2,007 adverse events reported
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