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AboutPricing
Drug ReportsBenazepril
Benazepril
/ Benazepril, Benazepril, Benazepril /, Lotensin, Lotrel (benazepril) is a small molecule pharmaceutical. Benazepril was first approved as Lotensin on 1991-06-25. It is used to treat diabetic nephropathies, heart failure, hypertension, and left ventricular dysfunction in the USA. The pharmaceutical is active against angiotensin-converting enzyme.
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Novartis Pharmaceuticals
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
cardiovascular diseasesD002318
endocrine system diseasesD004700
Trade Name
FDA
EMA
Benazepril, Lotensin (discontinued: Benazepril, Lotensin)
Combinations
Amlodipine besylate benazepril, Benazepril hydrochlorothiazide, Lotensin, Lotrel (discontinued: Amlodipine besylate benazepril, Benazepril hydrochlorothiazide, Lotensin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Benazepril hydrochloride
Tradename
Company
Number
Date
Products
LOTENSINValidus PharmaceuticalsN-019851 RX1991-06-25
3 products, RLD
Show 1 discontinued
Benazepril hydrochloride
+
Hydrochlorothiazide
Tradename
Company
Number
Date
Products
LOTENSIN HCTValidus PharmaceuticalsN-020033 RX1992-05-19
3 products, RLD
Show 1 discontinued
Amlodipine besylate
+
Benazepril hydrochloride
Tradename
Company
Number
Date
Products
LOTRELSandozN-020364 RX1995-03-03
6 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
amlobenzANDA2010-04-09
amlodipine and benazepril hydrochlorideANDA2025-03-05
amlodipine and benazepril hydrochloride amlodipine besylateANDA2025-01-17
amlodipine besylateANDA2021-01-12
amlodipine besylate and benazepril hclANDA2010-03-19
amlodipine besylate and benazepril hydrochlorideANDA2025-01-15
benazeprilANDA2019-01-15
benazepril benazepril hydrochlorideANDA2021-09-20
benazepril hclANDA2016-06-23
benazepril hydrochlorideANDA2025-03-24
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
heart failureEFO_0003144D006333I50
diabetic nephropathiesEFO_0000401D003928—
hypertensionEFO_0000537D006973I10
left ventricular dysfunction—D018487—
coronary artery disease—D003324I25.1
variant angina pectoris—D000788I20.1
nephrotic syndromeEFO_0004255D009404N04
edema—D004487R60.9
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C09: Agents acting on the renin-angiotensin system
— C09A: Ace inhibitors, plain
— C09AA: Ace inhibitors, plain
— C09AA07: Benazepril
— C09B: Ace inhibitors, combinations
— C09BA: Ace inhibitors and diuretics
— C09BA07: Benazepril and diuretics
— C09BB: Ace inhibitors and calcium channel blockers
— C09BB13: Benazepril and amlodipine
HCPCS
No data
Clinical
Clinical Trials
54 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———3————3
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBenazepril
INNbenazepril
Description
Benazepril is a benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a prodrug. It is a benzazepine, a dicarboxylic acid monoester, an ethyl ester and a lactam. It is functionally related to a benazeprilat. It is a conjugate base of a benazepril(1+).
Classification
Small molecule
Drug classantihypertensives (ACE inhibitors)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O
Identifiers
PDB—
CAS-ID86541-75-5
RxCUI—
ChEMBL IDCHEMBL838
ChEBI ID3011
PubChem CID5362124
DrugBankDB00542
UNII IDUDM7Q7QWP8 (ChemIDplus, GSRS)
Target
Agency Approved
ACE
ACE
Organism
Homo sapiens
Gene name
ACE
Gene synonyms
DCP, DCP1
NCBI Gene ID
1636
Protein name
angiotensin-converting enzyme
Protein synonyms
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, peptidase P
Uniprot ID
Q7M4L4
Mouse ortholog
Ace (11421)
angiotensin-converting enzyme (P09470)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Benazepril
+
Amlodipine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Price per prescription (USD)
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Benazepril
Total medical expenditures per year (USD, in millions)
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Benazepril
+
Hydrochlorothiazide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,627 documents
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Safety
Black-box Warning
Black-box warning for: Amlobenz, Amlodipine and benazepril hydrochloride, Amlodipine besylate and benazepril hcl, Amlodipine besylate and benazepril hydrochloride, Benazepril hydrochloride, Benazepril hydrochloride and hydrochlorothiazide, Lotensin, Lotensin hct, Lotrel
Adverse Events
Top Adverse Reactions
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4,628 adverse events reported
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